Complete Genome Sequence of Super Biofilm-Elaborating Staphylococcus aureus Isolated in Japan

Abstract

Staphylococcus aureus JP080, previously named TF2758, is a clinical isolate from an atheroma and a super biofilm-elaborating strain whose biofilm elaboration is dependent solely on polysaccharide poly-N-acetylglucosamine/polysaccharide intercellular adhesin (PNAG/PIA). Here, we report the complete genome sequence of strain JP080, which consists of one chromosome and one circular plasmid.

New Molecular Mechanism of Superbiofilm Elaboration in a Staphylococcus aureus Clinical Strain

“…Intriguingly, the complementation of JP080 with wild-type rob did not completely abolish the superbiofilm-elaborating phenotype. Consequently, we obtained the complete genome sequence of JP080 ( 14 ) and searched for mutations or deletions in the gene(s) relevant to biofilm hyperproduction. We found another missense mutation at position 103 (G to A) in the icaR gene, characterized by an amino acid substitution of alanine by threonine in codon 35 (Ala35Thr) of the protein ( Fig.…”

Biofilm formation by Staphylococcus aureus Isolation from atopic Dermatitis Patients on Defined Lewis Types saliva

“…Staphylococcus aureus (S. aureus) is regular pathogen related with different diseases and biofilm of the bacterium was observed to be associated with an assortment of microbial infection and to expand harmfulness [2] [3] [4]. S. aureus biofilm is made out of three noteworthy segments,the polysaccharide poly-N-acetylglucosamine (PNAG), otherwise called polysaccharide intercellular attachment (PIA), cell surface and emitted bacterial proteins, and extracel-lular nucleic acid, which shape extracellular polymeric substances [5]. Atopic dermatitis (AD) is an interminable fiery skin illness typically beginning in early youth with a revealed lifetime commonness of 15 -30% in youngsters, while the com-paring figure for adults is 2-10%.…”