Complete Genome Sequence of an Emergent Recombinant GII.P16-GII.2 Norovirus Strain Associated with an Epidemic Spread in the Winter of 2016-2017 in Hong Kong, China

Chan, Martin C.W.; Kwok, Ka‐li; Hung, T. F.; Chan, Lai-kwan; Chan, Paul K.S.

doi:10.1128/genomea.00343-17

Cited by 10 publications

(9 citation statements)

References 6 publications

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“…Genome coverage was 95.1%, and the mean sequencing depth was 1,980ϫ. The viral sequence was confirmed by de novo assembly using SPAdes 3.13.0 (8) in metagenomic mode and by full-length virus capsid Sanger se-quencing (5). The two methods yielded consistent results.…”

mentioning

confidence: 84%

Genome Sequence of a Human Norovirus GII.4 Hong Kong[P31] Variant in Hong Kong, China

Tse

Zhang

Lau

et al. 2020

Microbiol Resour Announc

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mentioning

confidence: 84%

Genome Sequence of a Human Norovirus GII.4 Hong Kong[P31] Variant in Hong Kong, China

Tse

Zhang

Lau

et al. 2020

Microbiol Resour Announc

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“…The data set included strains detected from 1976 to 2016 and the reemerging GII.P16-GII.2 strains detected during the 2016-2017 season (20, 37). The capsid and polymerase genotypes (when available) were confirmed using the online-based norovirus Typing Tool (8).…”

Section: Methodsmentioning

confidence: 99%

Phylogenetic Analyses Suggest that Factors Other Than the Capsid Protein Play a Role in the Epidemic Potential of GII.2 Norovirus

Tohma

Lepore

Ford-Siltz

et al. 2017

mSphere

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Noroviruses are a major cause of gastroenteritis worldwide. Currently, there is no vaccine or specific antiviral available to treat norovirus disease. Multiple norovirus strains infect humans, but a single genotype (GII.4) has been regarded as the most important cause of viral gastroenteritis outbreaks worldwide. Its persistence and predominance have been explained by the continuous replacement of variants that present new antigenic properties on their capsid protein, thus evading the herd immunity acquired to the previous variants. Over the last three seasons, minor genotypes have displaced the GII.4 viruses as the predominant strains. One of these genotypes, GII.2, reemerged as predominant during 2016 to 2017. Here we show that factors such as minor changes in the polymerase may have driven the reemergence of GII.2 during the last season. A better understanding of norovirus diversity is important for the development of effective treatments against noroviruses.

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“…Recently, a novel GII.17 Kawasaki 2014 variant has replaced the previously dominant GII.4 (2012) Sydney variants in several countries in Asia . In addition, during the winter of 2016‐2017, NoV GII.2 has increased and been reported as the dominant genotype in several countries worldwide …”

Section: Introductionmentioning

confidence: 99%

Distribution of norovirus and sapovirus genotypes with emergence of NoV GII.P16/GII.2 recombinant strains in Chiang Mai, Thailand

Supadej

Khamrin

Kumthip

et al. 2018

Journal of Medical Virology

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Norovirus (NoV) and sapovirus (SaV) are recognized as the causative agents of acute gastroenteritis, and NoV is one of the leading pathogens reported worldwide. This study reports on the distribution of NoV and SaV genotypes in children hospitalized with acute gastroenteritis in Chiang Mai, Thailand, from January 2015 to February 2017. From a total of 843 stool samples, 170 (20.2%) and 16 (1.9%) were identified as having NoV and SaV infections, respectively. Two samples (0.2%) were positive for both NoV and SaV. Of these, NoV GII.4 (57.2%) was the dominant genotype, followed by GII.2, GII.3, GII.17, GII.6, GII.7, GII.13, GII.14, GII.15, GII.21, GI.6, and GI.5. Among the NoV GII.4 variants, Sydney 2012 was the dominant variant during the period 2015-2016, while the other variants detected in this study were Asia 2003 and New Orleans 2009. Interestingly, an increase of NoV GII.2 was observed in 2016 and 2017. Characterization of partial RNA-dependent RNA polymerase and VP1 nucleotide sequences of GII.2 strains revealed that more than half of the GII.2 strains circulating in 2016 and 2017 were recombinant strains of GII.P16/GII.2. For SaV, the majority of strains belonged to GI.1 (55.6%) and GI.2 (33.3%), while GII.5 accounted for 11.1%. In conclusion, this study demonstrates the diversity of NoV and SaV, and the emergence of NoV GII.P16/GII.2 recombinant strains in 2016 and 2017 in Chiang Mai, Thailand.

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Complete Genome Sequence of an Emergent Recombinant GII.P16-GII.2 Norovirus Strain Associated with an Epidemic Spread in the Winter of 2016-2017 in Hong Kong, China

Cited by 10 publications

References 6 publications

Genome Sequence of a Human Norovirus GII.4 Hong Kong[P31] Variant in Hong Kong, China

Genome Sequence of a Human Norovirus GII.4 Hong Kong[P31] Variant in Hong Kong, China

Phylogenetic Analyses Suggest that Factors Other Than the Capsid Protein Play a Role in the Epidemic Potential of GII.2 Norovirus

Distribution of norovirus and sapovirus genotypes with emergence of NoV GII.P16/GII.2 recombinant strains in Chiang Mai, Thailand

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