Complete Genome Sequence of a 2019 Novel Coronavirus (SARS-CoV-2) Strain Isolated in Nepal

Sah, Ranjit; Rodríguez-Morales, Alfonso J.; Jha, Runa; Chu, Daniel K W; Gu, Hongcang; Peiris, Malik; Bastola, Anup; Lal, Bibek Kumar; Ojha, Hemant Chanda; Rabaan, Ali A.; Zambrano, Lysien I.; Costello, Anthony; Morita, Kouichi; Pandey, Basu Dev; Poon, Leo L M

doi:10.1128/mra.00169-20

Cited by 144 publications

(140 citation statements)

References 6 publications

(1 reference statement)

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“…Coronaviruses belong to the subfamily Coronavirineae in the family of coronavitidae of the order nidovirales. The subfamily includes: Alpha Coronavirus, Beta Coronavirus, Gamma Coronavirus and Delta Coronavirus [4,5]. The genome is a single-stranded positive-sense RNA (30 kb) with a 5′ cap structure and a 3′-poly-A tail.…”

Section: The Virus Responsible For Covid-19mentioning

confidence: 99%

Toward understanding the 2019 Coronavirus and its impact on the heart

Becker¹

2020

J Thromb Thrombolysis

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Section: The Virus Responsible For Covid-19mentioning

confidence: 99%

Toward understanding the 2019 Coronavirus and its impact on the heart

Becker¹

2020

J Thromb Thrombolysis

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“…The patient screening, environmental control measures, personal and equipment protection, and critical care operations should be needed for taking care of local outbreaks of SARS-CoV-2 [29] . The complete genome sequence of SARS-CoV-2 virus strain has been elucidated from Nepal person who recently returned from, Wuhan China [30] and from other countries as well and till date 170 such partial/ complete genome sequence available online in NCBI database.…”

Section: Transmission Of Coronavirusmentioning

confidence: 99%

Insights of Novel Coronavirus (SARS-CoV-2) disease outbreak, management and treatment

Kumar¹,

Batra²,

Malik

2020

AIMS Microbiology

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Emerging and re-emerging viral diseases poses a threat to living organisms, and led to serious concern to humankind and public health. The last two decades, viral epidemics such as the severe acute respiratory syndrome (SARS-CoV) reported in the years 2002–2003, and H1N1 influenza (Swine flu) in 2009, middle east respiratory syndrome (MERS-CoV) from Saudi Arabia in 2012, Ebola virus in 2014–2016, and Zika virus in 2015. The recent outbreak of 2019-CoV-2 or severe acute respiratory syndrome-2 (SARS-CoV-2), novel coronavirus (2019-nCoV, or 2019 disease, COVID-19) in Dec 2019, from, Wuhan city of China, has severe implications of health concerns to the whole world, due to global spread and high health risk. More than 423349 deaths had occurred globally and is still increasing every day. The whole world is under a health emergency, and people are advised to stay at their homes to avoid the spread of person-to-person infection, and advised to maintain social distancing. The advancement in clinical diagnosis techniques like Real-Time PCR (RT-PCR), immunological, microscopy, and geographic information system (GIS) mapping technology helped in tacking the rapid diagnosis and tracking viral infection in a short period. In the same way, artificial intelligence (AI), combinatorial chemistry, and deep learning approaches help to find novel therapeutics in less time and wide applicability in biomedical research. National Institute of Allergy and Infectious Diseases (NIAID) has started the clinical trials of investigation COVID-19 vaccine. Therefore, we can expect vaccines to be available for this deadly disease in the coming few months.

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“…In Nepal the rst con rmed case of SARS-CoV-2 infections was a native student, studying in Wuhan, with symptom onset on 3rd January 2020 con rmed as an index case on 23rd January followed by migrants from Middle East countries and majorly from India [12]. Over 16 thousands positive cases of SARS-CoV-2 from Nepal have been reported by the WHO and MoHP as of July 13, 2020 [11] in all 77 districts in Nepal.…”

Section: Introductionmentioning

confidence: 99%

“…Over 16 thousands positive cases of SARS-CoV-2 from Nepal have been reported by the WHO and MoHP as of July 13, 2020 [11] in all 77 districts in Nepal. Previous studies from Nepal focused on mental assessment of COVID-19 patients and normal people [13,14] awareness, challenge and hospital disaster preparedness plans [15,16], clinical pro le [17,18] and viral genome status [12].…”

Section: Introductionmentioning

confidence: 99%

Spatial Distribution and Trend Analysis of Current Status of COVID-19 in Nepal and Global Future Preventive Perspectives

Pant

Bahadur

Bishwakarma

et al. 2020

Preprint

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Background: Coronavirus disease (COVID-19) is a recently discovered severe and contagious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has received worldwide attention. The risk of COVID-19 is serious for the infected persons of chronic diseases as well as vulnerable populations including elder group. Still, the present scenario of scarcity of effective treatment options and limited recovery rate of ongoing treatment are prevailed in Nepal. This study aims to analyze the spatial distribution and trends of COVID-19 with the help of geographic information system (GIS) software and outlook future preventive perspectives.Methods: In this research work, we used GIS tool ArcGIS 10.4.1 to map the distribution patterns of population of COVID-19 cases. Federal, provincial and district level daily cases data of COVID-19 confirmed, cured and death from 23rd January to 13th July 2020 were obtained from the Ministry of Health and Population (MoHP), Government of Nepal. In addition, we reviewed several peer-reviewed research papers to summarize the global scenarios and preventive perspectives on COVID-19.Results: In context to Nepal SARS-CoV-2 has spread throughout the country infecting 16,945 persons in all 77 districts, as of 13th July, 2020. Confirmed, cured and death cases experienced an upward trend up to 1st July, 2020 followed by downward trend as of 13th July, 2020. Over 70% of total confirmed cases of reported COVID-19 patients were from the lowland-plain area. Spatial clustering suggested that provinces 2 and 5 were at potentially increased risk of COVID-19, and Province 1 and Bagmati province could be grouped as future "hot spots". In addition, we proposed four strategies namely, identification of the key medical and social elements, discovery and development of treatment options for a future pandemic, investing in ethno-medicine research and epidemic preparedness of health care system to decrease the efficacy of calamities of future pandemics.Conclusion: Our study demonstrates one of the best ways to protect; control and sluggish transmission of SARS-CoV-2 could be achieved by monitoring active ties using GIS spatial analysis. And, the severity of future pandemic could be minimized by integrative action on the abovementioned four different preventive master plans.

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Complete Genome Sequence of a 2019 Novel Coronavirus (SARS-CoV-2) Strain Isolated in Nepal

Abstract: A complete genome sequence was obtained for a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strain isolated from an oropharyngeal swab specimen of a Nepalese patient with coronavirus disease 2019 (COVID-19), who had returned to Nepal after traveling to Wuhan, China.

Cited by 144 publications

References 6 publications

Toward understanding the 2019 Coronavirus and its impact on the heart

Toward understanding the 2019 Coronavirus and its impact on the heart

Insights of Novel Coronavirus (SARS-CoV-2) disease outbreak, management and treatment

Spatial Distribution and Trend Analysis of Current Status of COVID-19 in Nepal and Global Future Preventive Perspectives

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