Complete Genome of Bacillus pumilus Siphophage Blastoid

Mash, Scott J.; Minahan, Nicholas T.; Chamakura, Karthik R.; Everett, Gabriel F. Kuty

doi:10.1128/genomea.00854-13

Cited by 3 publications

(3 citation statements)

References 11 publications

(11 reference statements)

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“…are well-documented bacteria, yet only ∼100 Bacillus phage genomes have been sequenced (NCBI Genome database search, 19 January 2018). B. pumilus phages have fewer than 15 sequenced genomes ( 1 – 6 ). The first B. pumilus phage that was isolated differs from other Bacillus phages in burst size and latent period ( 7 ).…”

Section: Genome Announcementmentioning

confidence: 99%

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Complete Genome Sequence of the Bacillus pumilus Phage Leo2

et al. 2018

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Section: Genome Announcementmentioning

confidence: 99%

“…Since then, several studies have isolated and characterized B. pumilus phages without sequencing ( 8 – 12 ). Recent studies have reduced the knowledge gap in B. pumilus phage genetics by finding, clustering, and annotating several phages ( 1 – 6 ).…”

Section: Genome Announcementmentioning

confidence: 99%

Complete Genome Sequence of the Bacillus pumilus Phage Leo2

et al. 2018

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“…Genome announcements have increasingly become opportunities for making publication feasible for these young scientists. [25][26][27][28][29][30] Several of these papers were published as a result of a partnership between the Texas A&M program and members of the SEA-PHAGES community. Graduates of the phage discovery program are "hooked" on scientific research in general and are extremely excited about the potential use of phages in medicine, agriculture and biotechnology.…”

Section: Student Discoveries Must Be Significant and Continue To Be Umentioning

confidence: 99%

Phage on the stage

Temple¹,

Lewis

2015

Bacteriophage

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Genomic comparison of 93 Bacillus phages reveals 12 clusters, 14 singletons and remarkable diversity

et al. 2014

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BackgroundThe Bacillus genus of Firmicutes bacteria is ubiquitous in nature and includes one of the best characterized model organisms, B. subtilis, as well as medically significant human pathogens, the most notorious being B. anthracis and B. cereus. As the most abundant living entities on the planet, bacteriophages are known to heavily influence the ecology and evolution of their hosts, including providing virulence factors. Thus, the identification and analysis of Bacillus phages is critical to understanding the evolution of Bacillus species, including pathogenic strains.ResultsWhole genome nucleotide and proteome comparison of the 93 extant Bacillus phages revealed 12 distinct clusters, 28 subclusters and 14 singleton phages. Host analysis of these clusters supports host boundaries at the subcluster level and suggests phages as vectors for genetic transfer within the Bacillus cereus group, with B. anthracis as a distant member of the group. Analysis of the proteins conserved among these phages reveals enormous diversity and the uncharacterized nature of these phages, with a total of 4,922 protein families (phams) of which only 951 (19%) had a predicted function. In addition, 3,058 (62%) of phams were orphams (phams containing a gene product from a single phage). The most populated phams were those encoding proteins involved in DNA metabolism, virion structure and assembly, cell lysis, or host function. These included several genes that may contribute to the pathogenicity of Bacillus strains.ConclusionsThis analysis provides a basis for understanding and characterizing Bacillus phages and other related phages as well as their contributions to the evolution and pathogenicity of Bacillus cereus group bacteria. The presence of sparsely populated clusters, the high ratio of singletons to clusters, and the large number of uncharacterized, conserved proteins confirms the need for more Bacillus phage isolation in order to understand the full extent of their diversity as well as their impact on host evolution.

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Complete Genome of Bacillus pumilus Siphophage Blastoid

Abstract: Phage Blastoid is a siphophage that infects Bacillus pumilus. B. pumilus is widely used in agriculture but has recently been linked to cases of food poisoning. Here, we report the complete genome of Blastoid and discuss unique genomic characteristics.

Cited by 3 publications

References 11 publications

Complete Genome Sequence of the Bacillus pumilus Phage Leo2

Complete Genome Sequence of the Bacillus pumilus Phage Leo2

Phage on the stage

Genomic comparison of 93 Bacillus phages reveals 12 clusters, 14 singletons and remarkable diversity

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