Complete genome analysis reveals secondary metabolite biosynthetic capabilities of Streptomyces sp. R527F isolated from the Arctic Ocean

Duan, Zedong; Liao, Li; Chen, Bin

doi:10.1016/j.margen.2022.100949

Cited by 4 publications

(4 citation statements)

References 19 publications

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“…Moreover, as is seen with respect to the antimicrobial evaluation of terrestrial secondary metabolites, the antimicrobial evaluation of marine secondary metabolites likewise identifies innumerable structures possessing modest to good antibacterial activity [ 34 ]. Inventories of these structures are published regularly [ 15 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 ]. Within these inventories are found structures that are truly distinctive, often in the multiple aspects of their biosynthesis, ring construction, and biological activity.…”

Section: Do Marine Organisms Biosynthesize Exceptional Inhibitors Of ...mentioning

confidence: 99%

“…Recognition that the biosynthetic source of these marine structures is in many cases marine bacteria is complemented by a growing understanding of what bacteria to culture and how to genetically manipulate the bacteria. These questions regarding marine bacteria, as in the case of marine Streptomyces [ 13 , 14 , 15 , 16 ], may address the difficulty of understanding the ecological role of “antibiotic” secondary metabolites [ 17 , 18 ], so as to enable activation of their biosynthetic gene clusters. Practical solutions to this challenge were discussed recently with reference to lasonolide A, another as yet promising marine antitumor antibiotic [ 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

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β-Lactams from the Ocean

Fisher

Mobashery

2023

Marine Drugs

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The title of this essay is as much a question as it is a statement. The discovery of the β-lactam antibiotics—including penicillins, cephalosporins, and carbapenems—as largely (if not exclusively) secondary metabolites of terrestrial fungi and bacteria, transformed modern medicine. The antibiotic β-lactams inactivate essential enzymes of bacterial cell-wall biosynthesis. Moreover, the ability of the β-lactams to function as enzyme inhibitors is of such great medical value, that inhibitors of the enzymes which degrade hydrolytically the β-lactams, the β-lactamases, have equal value. Given this privileged status for the β-lactam ring, it is therefore a disappointment that the exemplification of this ring in marine secondary metabolites is sparse. It may be that biologically active marine β-lactams are there, and simply have yet to be encountered. In this report, we posit a second explanation: that the value of the β-lactam to secure an ecological advantage in the marine environment might be compromised by its close structural similarity to the β-lactones of quorum sensing. The steric and reactivity similarities between the β-lactams and the β-lactones represent an outside-of-the-box opportunity for correlating new structures and new enzyme targets for the discovery of compelling biological activities.

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Section: Do Marine Organisms Biosynthesize Exceptional Inhibitors Of ...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

β-Lactams from the Ocean

Fisher

Mobashery

2023

Marine Drugs

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“…In recent years, with the increase in the number of Streptomyces genomes published, Streptomyces genomes have been confirmed to contain a wide range of undiscovered BGCs, which can serve as an invaluable source for the discovery of novel drug leads [ 24 ]. Furthermore, a large number of novel BGCs have been discovered in the genomes of Streptomyces species originating from Arctic and Antarctic habitats [ 25 , 26 , 27 ], indicating that Streptomyces strains in polar regions have strong potential for containing new secondary metabolites. Therefore, identifying novel Streptomyces species in polar regions can provide a basis for mining novel genetic sources for new natural products.…”

Section: Introductionmentioning

confidence: 99%

A Genomics-Based Discovery of Secondary Metabolite Biosynthetic Gene Clusters in the Potential Novel Strain Streptomyces sp. 21So2-11 Isolated from Antarctic Soil

Du,

Han,

Hao

et al. 2024

Microorganisms

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Streptomyces species are attractive sources of secondary metabolites that serve as major sources of antibiotics and other drugs. In this study, genome mining was used to determine the biosynthetic potential of Streptomyces sp. 21So2-11 isolated from Antarctic soil. 16S rRNA gene sequencing revealed that this strain is most closely related to Streptomyces drozdowiczii NBRC 101007T, with a similarity of 98.02%. Genome comparisons based on average nucleotide identity (ANI) and digital DNA–DNA hybridization (dDDH) showed that strain 21So2-11 represents a novel species of the genus Streptomyces. In addition to a large number of genes related to environmental adaptation and ecological function, a total of 28 putative biosynthetic gene clusters (BGCs) responsible for the biosynthesis of known and/or novel secondary metabolites, including terpenes, lantipeptides, polyketides, nonribosomal peptides, RiPPs and siderophores, were detected in the genome of strain 21So2-11. In addition, a total of 1456 BGCs were predicted to contribute to the biosynthesis of more than 300 secondary metabolites based on the genomes of 47 Streptomyces strains originating from polar regions. The results indicate the potential of Streptomyces sp. 21So2-11 for bioactive secondary metabolite production and are helpful for understanding bacterial adaptability and ecological function in cold terrestrial environments.

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“…The "Modern Actinobacteria" (MOD-ACTINO) has been the focus lately to uncover Actinobacteria from unique sources with bioactive potentials [1,2] . Actinobacteria are present in diverse habitats such as terrestrial soil [3,4] , marine [5,6] , pond [7,8] , desert [9][10][11] , cave [12][13][14] , glacier [15,16] , hot spring [17,18] , Artic and Antarctic zones [19][20][21][22] , and mangrove [23][24][25][26] . This phylum of bacteria can survive in a wide range of environmental conditions through their complex multicellular life cycle and the development of unique defence mechanisms, notably observed in the genus Streptomyces [27][28][29] .…”

Section: Introductionmentioning

confidence: 99%

Streptomyces griseiviridis sp. nov., A Novel “Modern Actinobacteria” isolated from Malaysia Mangrove Soil

Law¹,

Tan²,

Letchumanan³

et al. 2023

Prog Micobes Mol Biol

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A novel strain, Streptomyces griseiviridis MUM 136JT was recovered from a mangrove forest soil in Malaysia. The Gram-positive bacterium forms strong yellow aerial mycelium and moderate yellow substrate mycelium on ISP 2 agar. A polyphasic approachwas used to determine the taxonomy status of strain MUM 136JT. The strain showed a spectrum of phylogenetic and chemotaxonomic properties consistent with those of the members of the genus Streptomyces. The cell wall peptidoglycan was determined to contain LL-diaminopimelic acid. The predominant menaquinones were identified as MK-9(H8) and MK-9(H6), while the identified polar lipids consisted of lipid, aminolipid, phospholipid, phosphatidylglycerol, phosphatidylinositol, phosphatidylethanolamine, diphosphatidylglycerol, and phosphatidylinositolmannoside. The cell wall sugars consist of ribose, mannose, and galactose. The predominant cellular fatty acids (>10.0 %) were identified as iso-C16:0 (31.6 %), anteiso-C15:0 (14.8 %), iso-C15:0 (12.0 %), and anteiso-C17:0 (11.1 %). Phylogenetic analysis identified that closely related strains for MUM 136JT are Streptomyces leeuwenhoekii DSM 42122T (98.9 %), Streptomyces erythrogriseus JCM 9650T (98.4 %), Streptomyces griseoincarnatus JCM 4381T (98.5 %). The DNA-DNA relatedness values between MUM 136 JT and closely related type strains ranged from 13.3 ± 1.5 % to 17.4 ± 2.0 %. The name Streptomyces griseiviridis sp. nov. is proposed, and the type strain is MUM 136JT (= NBRC 114249T = MCCC 1K04199T).

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Complete genome analysis reveals secondary metabolite biosynthetic capabilities of Streptomyces sp. R527F isolated from the Arctic Ocean

Cited by 4 publications

References 19 publications

β-Lactams from the Ocean

β-Lactams from the Ocean

A Genomics-Based Discovery of Secondary Metabolite Biosynthetic Gene Clusters in the Potential Novel Strain Streptomyces sp. 21So2-11 Isolated from Antarctic Soil

Streptomyces griseiviridis sp. nov., A Novel “Modern Actinobacteria” isolated from Malaysia Mangrove Soil

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