Streptomyces griseiviridis sp. nov., A Novel “Modern Actinobacteria” isolated from Malaysia Mangrove Soil

This in-depth study explores various aspects of cutaneous leishmaniasis, shedding light on the physiopathology of the infection, advances in molecular diagnostic techniques, and therapeutic approaches currently in development. Our investigation seamlessly integrates fundamental and clinical research data to provide a comprehensive perspective on this debilitating disease. Cutaneous leishmaniasis, primarily manifested through skin lesions, poses a significant diagnostic challenge. We delve into molecular diagnostic methods, especially PCR, emphasizing their crucial role in accurately detecting the infection. Simultaneously, we examine the implications of the physiopathology of cutaneous leishmaniasis, unveiling the complex mechanisms underlying this disease. In terms of treatment, we scrutinize current therapeutic approaches, highlighting limitations associated with using antimonials. Our study also explores alternative solutions, investigating the potential benefits of flavonoids and other natural compounds, thus offering innovative therapeutic perspectives. In conclusion, this research aims to enhance the understanding of cutaneous leishmaniasis from a diagnostic and therapeutic standpoint. This review is an essential resource for healthcare professionals and researchers, laying the groundwork for an integrated and holistic approach to better comprehend and treat this complex disease.

Section: Streptomyces: Bacterial Heroes In the Battle Against Cutaneo...mentioning

confidence: 99%

Cutaneous Leishmaniasis: Physiopathology, Molecular Diagnostic, and Therapeutic Approaches

Balahbib,

Hmamouch,

El Allam

et al. 2023

“…Recent research has been looking into alternative treatment methods to manage the populations of V. parahaemolyticus and reduce the spread of AMR in our surrounding environments [71][72][73][74] . A compelling candidate is Streptomyces sp., a group of Gram-positive, filamentous bacteria belonging to the phylum Actinobacteria [75] . They are abundant in nature and have been frequently isolated from various sources such as soils, mangroves, and marine environments [76][77][78][79][80][81] .…”

Section: Data Descriptionmentioning

confidence: 99%

“…Moreover, Streptomyces sp. has shown various bioactivities, including antioxidative, anticancer, cytotoxic, antibacterial, and more specifically anti-Vibrio properties [46,[89][90][91] .…”

Section: Data Descriptionmentioning

confidence: 99%

Complete Whole Genome Sequence of Vibrio parahaemolyticus RP0132 Strain Isolated from Shrimp in Malaysia

Loo,

Tan,

Law

et al. 2023

Vibrio parahaemolyticus is a Gram-negative, halophilic bacterium that is ubiquitous in marine environments. Its perilous co-existence with aquatic animals increases the risk of infections and diseases, especially those in aquaculture systems, thus resulting in reduced production and economic losses in the aquaculture industry. Moreover, V. parahaemolyticus can be easily transmitted to humans via consumption of contaminated seafood, resulting in gastroenteritis outbreaks. However, the rise in multidrug resistance within the species has challenged the efficacy of antimicrobial treatments against V. parahaemolyticus infections. Therefore, we report the genome sequence of V. parahaemolyticus RP0132 isolated from shrimp to gain insight into its antimicrobial resistance traits and potential resistance mechanisms. The findings will facilitate the development of effective anti-Vibrio agents to manage V. parahaemolyticus infections.

“…MUM 178J, the isolate was subjected to complete whole genome sequencing. This aims to identify the biosynthetic gene clusters (BGC) responsible for the production of the bioactive compound(s) associated with its anti-Vibrio activity through genome mining and to gain insight into the genomic characteristics of MUM 178J [62][63][64][65][66] .…”

Section: Introductionmentioning

confidence: 99%

Complete Whole-Genome Sequence of Streptomyces sp. MUM 178J, a Potential Anti-Vibrio Agent

Loo,

Tan,

Chua

et al. 2024

Streptomyces sp. is a group of filamentous, Gram-positive bacteria notoriously known for their capabilities in producing bioactive compounds that have been used as novel drugs and lead in drug development. The Streptomyces sp. MUM 178J was isolated from a mangrove forest in Malaysia. This isolate was found to harbor anti-Vibrio properties as its crude extract inhibited the growth of multidrug-resistant Vibrio parahaemolyticus. Therefore, the strain was subjected to whole genome sequencing to unearth its genomic potential. The genome of Streptomyces sp. MUM 178J consists of 6,699,249 bp with a G+C content of 71.3%. 66 tRNA genes and 18 rRNA genes were also predicted to be present within the genome. Further analysis with the bioinformatics tool, antiSMASH (antibiotics & Secondary Metabolite Analysis Shell), detected nine biosynthetic gene clusters displaying more than 70% similarity to known gene clusters, including one associated with melanin production. Melanin has demonstrated antagonistic activity against the growth of members of the Vibrio family, including V. parahaemolyticus. This indicates the potential correlation between the production of melanin and the anti-Vibrio properties of MUM 178J. The availability of the whole genome sequence of Streptomyces sp. MUM 178J allows for future in-depth investigation and potential exploitation of MUM 178J to harvest useful bioactive compounds.