Complete Barrett's Eradication Endoscopic Mucosal Resection: An Effective Treatment Modality for High-Grade Dysplasia and Intramucosal Carcinoma—An American Single-Center Experience

Chennat, Jennifer; Konda, Vani J.; Ross, Andrew; Tejada, Alberto Herreros de; Noffsinger, Amy; Hart, John; Shang, Lin; Ferguson, Mark K.; Posner, Mitchell C.; Waxman, Irving

doi:10.1038/ajg.2009.465

Cited by 222 publications

(176 citation statements)

References 56 publications

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“…Endoscopic resection has emerged as a promising treatment for HGD and early adenocarcinoma. [86][87][88][89] However, these methods are limited by disease recurrence, the frequent need for concurrent radiofrequency ablation, and ablation of the involved tissue. Endoscopic resection is also limited by the size of the nodule that can be removed, often requiring piecemeal resection and rendering histologic diagnosis difficult.…”

Section: Esophageal Diseasementioning

confidence: 99%

Extracellular Matrix as an Inductive Scaffold for Functional Tissue Reconstruction

Brown¹,

Badylak²

2016

Translating Regenerative Medicine to the Clinic

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Section: Esophageal Diseasementioning

confidence: 99%

Extracellular Matrix as an Inductive Scaffold for Functional Tissue Reconstruction

Brown¹,

Badylak²

2016

Translating Regenerative Medicine to the Clinic

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“…In Japan, there are a few case reports about the complete eradication of ESD for BE including Barrett ' s esophageal cancer, but this treatment is not used generally because the risk of developing synchronous or metachronous lesions is very low in Japan ( 41 ). Th erefore, in Japan, it is considered that it might not require circumferential EMR ( 42,43 ) nor radiofrequency ablation ( 43 -45 ), which is performed in Western countries for BE AC, and the recurrence rates of SCC were signifi cantly higher than those of AC.…”

Section: Esophagusmentioning

confidence: 99%

Comparison of the Long-Term Outcomes of Endoscopic Resection for Superficial Squamous Cell Carcinoma and Adenocarcinoma of the Esophagus in Japan

Nakagawa

Koike

Iijima

et al. 2014

American Journal of Gastroenterology

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OBJECTIVES:Few studies have simultaneously evaluated the long-term outcomes of endoscopic resection (ER) for squamous cell carcinoma (SCC) and adenocarcinoma (AC) of the esophagus in Japan. The objective of this study was to evaluate the long-term outcomes of ER for superfi cial esophageal cancer in consecutive patients. METHODS:This was a retrospective study from a single institution. From April 2001 to June 2012, 204 patients with SCC and 26 patients with AC were included from a total of 355 consecutive patients who were treated by esophageal ER at the Tohoku University Hospital. Patients with submucosal invasion deeper than 200 μ m and lymphovascular involvement were excluded. The intervention followed was endoscopic therapy. RESULTS:Overall survival, disease-free survival, and recurrence rates were evaluated as long-term outcomes. In the SCC group, during the median observation time of 36.5 months (range, 6 -120 months), 22 (10.8 % ) patients experienced metachronous recurrence, 4 (2.0 % ) patients experienced local recurrence, and 27 (13.2 % ) patients died from causes unrelated to SCC. In the AC group, during the median observation time of 45.5 months (range, 6 -131 months), one patient (3.8 % ) experienced metachronous recurrence and two (7.7 % ) died from causes unrelated to AC. The cumulative 5-year overall survival rates were not signifi cantly different between SCC (75.9 % ) and AC (88.9 % ) ( P = 0.120). The cumulative 5-year disease-free survival rates of SCC (57.1 % ) were signifi cantly lower than those of AC (85.2 % ; P = 0.017). The cumulative 5-year recurrence rates of SCC (32.0 % ) were signifi cantly higher than those of AC (4.2 % ; P = 0.023). CONCLUSIONS:The rate of recurrence after ER was higher in patients with SCC than that in patients with AC. These fi ndings suggest that, by detecting AC of the esophagus earlier, a satisfactory prognosis without recurrence can be expected after ER in Japan, and more rigorous endoscopic follow-up is necessary after ER in patients with SCC than in those with AC.

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“…However, the majority of these patients had IMC, whereas the rate of submucosal invasive cancer was decreased to 12.7 % (91). Subsequent studies from the surgical and endoscopic resection literature have reported even lower rates, between 4 % and 6.7 % (92,93).…”

Section: Endoscopic Therapies For Barrett Esophagusmentioning

confidence: 99%

“…1 and 2). furthermore, different studies have shown that staging by EMR can modify the previous biopsy diagnosis in up to 48 % of cases (93,102,103), which can dramatically change the clinical management of these patients, some of whom would be no longer suitable for endoscopic treatment due to histological evidence of submucosal invasion. Tumor staging using EMR pathology assessment is accurate when compared with surgical pathology, as shown in a study in 25 patients with HGD, IMC in Barrett's esophagus, where there was perfect agreement in T staging after EMR and esophagectomy (104).…”

Section: Endoscopic Mucosal Resection (Emr)mentioning

confidence: 99%

See 1 more Smart Citation

Endoscopic diagnosis and therapies for Barrett esophagus: a review

Waxman

González-Haba-Ruiz

Vázquez-Sequeiros

2014

Rev. esp. enferm. dig.

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Complete Barrett's Eradication Endoscopic Mucosal Resection: An Effective Treatment Modality for High-Grade Dysplasia and Intramucosal Carcinoma—An American Single-Center Experience

Cited by 222 publications

References 56 publications

Extracellular Matrix as an Inductive Scaffold for Functional Tissue Reconstruction

Extracellular Matrix as an Inductive Scaffold for Functional Tissue Reconstruction

Comparison of the Long-Term Outcomes of Endoscopic Resection for Superficial Squamous Cell Carcinoma and Adenocarcinoma of the Esophagus in Japan

Endoscopic diagnosis and therapies for Barrett esophagus: a review

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