Complete amino acid sequence of human plasma beta 2-glycoprotein I.

Lozier, Jay N.; Takahashi, Nobuhiro; Putnam, Frank W.

doi:10.1073/pnas.81.12.3640

Cited by 329 publications

(240 citation statements)

References 17 publications

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“…20 and 29). Briefly, ␤ 2 GPI is a 50-kd single-chain polypeptide (30) with 5 oligosaccharide attachment points (31,32). It is composed of 5 common, structurally related repeats known as complement control protein domains, each of which is ϳ60 amino acid residues in length, in addition to domain V, which contains 82 amino acids and a long carboxyl-terminal tail.…”

Section: Molecular Structure and Function Of ␤ 2 Gpimentioning

confidence: 99%

How do antiphospholipid antibodies bind β₂‐glycoprotein I?

Giles¹,

Isenberg²,

Latchman³

et al. 2003

Arthritis & Rheumatism

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Section: Molecular Structure and Function Of ␤ 2 Gpimentioning

confidence: 99%

How do antiphospholipid antibodies bind β₂‐glycoprotein I?

Giles¹,

Isenberg²,

Latchman³

et al. 2003

Arthritis & Rheumatism

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“…Nakaya et al (1980) demonstrated /~-glycoprotein I activation of lipoprotein lipase and designated this glycoprotein as apolipoprotein H (apo H). Lozier et al (1984) reported that apo H consisted of 326 amino acids and had five attached glucosamine-containing oligosaccharides. Hoeg et at.…”

Section: Introductionmentioning

confidence: 99%

Plasma apolipoprotein H (β2-glycoprotein I) phenotype frequencies in a Japanese population

Takamatsu¹,

Kishino²,

Suehiro³

et al. 1989

Jap J Human Genet

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SummaryWe determined plasma apolipoprotein H (/~2-glycoprotein I) levels in 300 healthy adult individuals and evaluated the frequencies of the Bg N and Bg D alleles in a Japanese population. These results were then compared with the previous reports. The plasma apo H levels in the subjects showed bimodal distribution: 274 subjects were in the range 15.6-33.2 mg/dl and were considered to be homozygous for Bg N (phenotype NN), and 26 subjects were found in the range 9.6-14.8 mg/dl and were presumably heterozygous for Bg N and Bg D (phenotype ND). In this study, no sample below 5 mg/dl (phenotype DD) was found. Mean plasma apo H levels in NN and ND groups were 22.1 + 1.6 mg/dl and 12.5_+ 1.6 mg/dl, respectively. The gene frequencies of Bg N and Bg D in a Japanese population were 0.957 and 0.043, respectively. These results were similar to gene frequencies of Bg ~ and Bg D in Caucasoids.

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“…10.1, 28.2k 10.8 and ApoH, also known as p2 glycoprotein-I, is a single, approximately 50 kDa chain glycoprotein (Lozier et al 1984) present in the blood in a mature 326 amino acid form and associated with plasma lipoproteins to the extent of 35% (Polz & Kostner 1979). Its chemical and physical characteristics, particularly its affinity for negatively charged molecules, suggest that apoH is a coagulation inhibitor.…”

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confidence: 99%

Influence of APOH protein polymorphism on apoH levels in normal and diabetic subjects

et al. 1997

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Apolipoprotein (apo)H (also known as β2 glycoprotein‐I) is a glycoprotein synthesized by liver cells and it is present in the blood associated with plasma lipoproteins. APOH displays a genetically determined structural polymorphism: three alleles (APOH*1, APOH*2, APOH*3) at a single locus on chromosome 17 code for different isoforms, and population studies have shown that APOH*2 is the most frequent allele. This paper assesses the relation between APOH phenotypes and plasma apoH levels in a population composed of 278 healthy subjects (243 H2/2, 32 H3/2, 2 H3/3, 1 H2/1; allele frequencies APOH*1 0.002, APOH*2 0.934, APOH*3 0.064) and 245 diabetics (212 H2/2, 30 H3/2, 3 H3/3; allele frequencies APOH*2 0.927 and APOH*3 0.073). Determination of apoH levels by competitive ELISA gave a mean value of 26.3 ± 9.8 mg/dl for all subjects, 22.6 ± 7.7 in normals vs 30.6 ± 10.3 in diabetics (p = 0.0001), and 23.0 ± 7.9, 19.3 ± 5.4 and 18.5 ± 3.5 mg/dl for H2/2, H3/2 and H3/3 in normals and 31.1 ± 10.1, 28.2 ± 10.8 and 15.7 ± 9.0 mg/dl in diabetics, respectively. ANCOVA of the adjusted data revealed a significant difference in apoH levels for the three phenotypes in both the normal subjects (p = 0.01) and the diabetics (p = 0.02). ANCOVA of the whole samples of subjects, controlling for diabetes as well as age, sex and total cholesterol, indicated a substantial effect of phenotype, independent of the other variables (p = 0.0007).

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Complete amino acid sequence of human plasma beta 2-glycoprotein I.

Abstract: We

Cited by 329 publications

References 17 publications

How do antiphospholipid antibodies bind β₂‐glycoprotein I?

How do antiphospholipid antibodies bind β₂‐glycoprotein I?

Plasma apolipoprotein H (β2-glycoprotein I) phenotype frequencies in a Japanese population

Influence of APOH protein polymorphism on apoH levels in normal and diabetic subjects

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Complete amino acid sequence of human plasma beta 2-glycoprotein I.

Abstract: We

Cited by 329 publications

References 17 publications

How do antiphospholipid antibodies bind β2‐glycoprotein I?

How do antiphospholipid antibodies bind β2‐glycoprotein I?

Plasma apolipoprotein H (β2-glycoprotein I) phenotype frequencies in a Japanese population

Influence of APOH protein polymorphism on apoH levels in normal and diabetic subjects

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Product

Resources

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How do antiphospholipid antibodies bind β₂‐glycoprotein I?

How do antiphospholipid antibodies bind β₂‐glycoprotein I?