Plasma apolipoprotein H (β2-glycoprotein I) phenotype frequencies in a Japanese population

Abstract

SummaryWe determined plasma apolipoprotein H (/~2-glycoprotein I) levels in 300 healthy adult individuals and evaluated the frequencies of the Bg N and Bg D alleles in a Japanese population. These results were then compared with the previous reports. The plasma apo H levels in the subjects showed bimodal distribution: 274 subjects were in the range 15.6-33.2 mg/dl and were considered to be homozygous for Bg N (phenotype NN), and 26 subjects were found in the range 9.6-14.8 mg/dl and were presumably heterozygous for Bg N and Bg D (phenotype ND). In this study, no sample below 5 mg/dl (phenotype DD) was found. Mean plasma apo H levels in NN and ND groups were 22.1 + 1.6 mg/dl and 12.5_+ 1.6 mg/dl, respectively. The gene frequencies of Bg N and Bg D in a Japanese population were 0.957 and 0.043, respectively. These results were similar to gene frequencies of Bg ~ and Bg D in Caucasoids.

Antibody specificity and related clinical features in antiphospholipid syndrome

“…27,30,31 It was also shown that anti-2 -GPI antibodies had low intrinsic affinity, and high-avidity binding to 2 -GPI was dependent on a multivalent attachment to immobilized antigen. 33 There is an interesting paper which reports that valine/leucine polymorphism at position 247 of 2 -GPI affects the reactivity of anti-2 -GPI antibodies. 33 There is an interesting paper which reports that valine/leucine polymorphism at position 247 of 2 -GPI affects the reactivity of anti-2 -GPI antibodies.…”