Complement regulatory protein genes in channel catfish and their involvement in disease defense response

Jiang, Chen; Zhang, Jiaren; Yao, Jun; Liu, Shikai; Li, Yun; Song, Lin; Li, Chao; Wang, Xiaozhu; Liu, Zhanjiang

doi:10.1016/j.dci.2015.06.002

Cited by 26 publications

(10 citation statements)

References 82 publications

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“…The proteins responsible for regulation of the complement activation (RCA) can be divided into two main groups: membrane-bound regulators and soluble regulators (27). Factor H Complement belongs to the RCA family and we found different alleles predominantly in LFE animals.…”

Section: Discussionmentioning

confidence: 70%

Potential Functional Variants in Innate Immune Response Genes Associated with Feed Efficiency in Beef Cattle

Ribeiro

César

Ferraz

et al. 2020

Preprint

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Background: Identifying and selecting animals for feed efficiency (FE) is extremely important for the beef production chain. Currently, the most common parameter to access the FE animals is residual feed intake (RFI), which is the residual of the linear regression that estimates DMI based on average daily gain and mid-test metabolic body weight. However, it relies on costly and time-consuming data collection, creating a growing demand for alternative approaches to identify genetically superior animals for FE. This study aimed to detect potential liver-specific functional variants from RNA-seq data of 16 Nellore bulls divergently selected for FE. Results: The variant call analysis detected 247 missense SNPs and nine insertion-deletions (INDELs) that alter the protein functions. These variants were found within 190 genes differentially found (P < 0.05) in liver tissue between high FE (HFE) and low FE (LFE) animals. To better understand the role of these variants in biological pathways, we performed a functional enrichment analysis, which highlighted six genes involved in complement cascade and cascade complement regulation pathways, and 20 genes involved in the regulation of the innate immune system. They had four different significant variants in the complement factor H (CFH) family genes, and all were homozygous in HFE animals rather than some degree of heterozygous in LFE animals. Conclusion: We developed a pipeline to detect potential liver-specific functional variants from RNA-seq data from animals divergently selected for feed efficiency. With this approach, we found potential functional variants in innate immune response genes associated with feed efficiency in beef cattle.

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Section: Discussionmentioning

confidence: 70%

Potential Functional Variants in Innate Immune Response Genes Associated with Feed Efficiency in Beef Cattle

Ribeiro

César

Ferraz

et al. 2020

Preprint

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“…Many gene families were induced after E. ictaluri infection, including heat shock proteins (Song et al, 2014, 2016; Xie et al, 2015), interlekin 17 (Wang X. et al, 2014), l-rhamnose-binding lectins (Thongda et al, 2014), nitric oxide synthase genes (Yao et al, 2014), claudins (Sun et al, 2015), peptidoglycan recognition proteins (Sun et al, 2014), Rab GTPases (Wang R. et al, 2014), Rho GTPase (Tan et al, 2017), suppressors of cytokine signaling genes (Yao et al, 2015), cytochrome P450 genes (Zhang et al, 2014), serpins (Li et al, 2015), bcl-2 genes (Yuan et al, 2016), cathepsins (Geng et al, 2015; Wang et al, 2015; Dong et al, 2016), tumor suppressor genes (Mu et al, 2015), complement regulatory protein genes (Jiang et al, 2015), septins (Fu et al, 2016), chemokines (Fu et al, 2017a,b,c), galectins (Zhou et al, 2016), apolipoproteins (Yang et al, 2017), receptor tyrosine kinases (Tian et al, 2015), NF-kB related genes (Wang et al, 2017c), phosphoinositide-3-kinases (Li et al, 2016), NCK and ABI adaptor genes (Zhou et al, 2017a), JAK and STAT genes (Jin et al, 2018). These studies indicated that most of the immune related genes were involved in the E. ictaluri disease responses.…”

Section: Part I: Enteric Septicemia Of Catfish (Esc)mentioning

confidence: 99%

A Review of Molecular Responses of Catfish to Bacterial Diseases and Abiotic Stresses

et al. 2018

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Catfish is one of the major aquaculture species in the United States. However, the catfish industry is threatened by several bacterial diseases such as enteric septicemia of catfish (ESC), columnaris disease and Aeromonas disease, as well as by abiotic stresses such as high temperature and low oxygen. Research has been conducted for several decades to understand the host responses to these diseases and abiotic stresses. With the development of sequencing technologies, and the application of genome-wide association studies in aquaculture species, significant progress has been made. This review article summarizes recent progress in understanding the molecular responses of catfish after bacterial infection and stress challenges, and in understanding of genomic and genetic basis for disease resistance and stress tolerance.

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“…The only overlapping gene was apoB-B that was up-regulated in intestine after ESC infection, but down-regulated in gill after columnaris infection. Such distinct expression pattern of the specific immune related genes was likely caused by very different pathogenesis of these two bacteria in different tissues (Fu et al, 2016;Jiang et al, 2015;Li et al, 2015b). ESC disease starts from intestine and spreads to internal tissues (liver, spleen, and kidney) (Shotts et al, 1986), while columnaris pathogen mainly infects external mucosal tissues gill and skin (Shoemaker et al, 2008).…”

Section: Expression Of Apolipoprotein Genes After E Ictaluri and F mentioning

confidence: 99%

Analysis of apolipoprotein genes and their involvement in disease response of channel catfish after bacterial infection

Yang

Zhou

et al. 2017

Developmental & Comparative Immunology

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Apolipoproteins are protein component of plasma lipoproteins. They exert crucial roles in lipoprotein metabolism and serve as enzyme cofactors, receptor ligands, and lipid transfer carriers in mammals. In teleosts, apolipoproteins are also involved in diverse processes including embryonic and ontogenic development, liver and digestive system organogenesis, and innate immunity. In this study, we identified a set of 19 apolipoprotein genes in channel catfish (Ictalurus punctatus). Phylogenetic analysis and syntenic analysis were conducted to determine their identities and evolutionary relationships. The expression signatures of apolipoproteins in channel catfish were determined in healthy tissues and after infections with two major bacterial pathogens, Edwardsiella ictaluri and Flavobacterium columnare. In healthy channel catfish, most apolipoprotein genes exhibited tissue-specific expression patterns in channel catfish. After ESC and columnaris infections, 5 and 7 apolipoprotein genes were differentially expressed respectively, which presented a pathogen-specific and time-dependent pattern of regulation. After ESC infection, three exchangeable apolipoproteins (apoA-IB, apoC-I, and apoE-B) were suppressed in catfish intestine, while two nonexchangeable apolipoproteins (apoB-A and apoB-B) were slightly up-regulated. After columnaris infection, apoB-B, apoD-B, and apoE-A were significantly down-regulated in catfish gill, while apoF, apoL-IV, apoO-like, and apo-14 kDa showed significantly up-regulation. Taken together, these results suggested that apolipoprotein genes may play significant roles in innate immune responses to bacterial pathogens in channel catfish.

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Complement regulatory protein genes in channel catfish and their involvement in disease defense response

Cited by 26 publications

References 82 publications

Potential Functional Variants in Innate Immune Response Genes Associated with Feed Efficiency in Beef Cattle

Potential Functional Variants in Innate Immune Response Genes Associated with Feed Efficiency in Beef Cattle

A Review of Molecular Responses of Catfish to Bacterial Diseases and Abiotic Stresses

Analysis of apolipoprotein genes and their involvement in disease response of channel catfish after bacterial infection

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