2020
DOI: 10.3390/medicina56090430
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Complement Properdin Determines Disease Activity in MRL/lpr Mice

Abstract: Background and objects: In systemic lupus erythematosus, circulating immune complexes activate complement and, when trapped in renal capillaries, cause glomerulonephritis. Mouse models have been used in the preclinical assessment of targeting complement activation pathways to manage chronic inflammation in lupus. Properdin is the only known positive regulator of complement activation, but its role in the severity of lupus nephritis has not been studied yet. Materials and Methods: Fully characterized properdin-… Show more

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Cited by 2 publications
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“…Not surprisingly, targeting properdin, either genetically or pharmacologically, has been shown to effective in countering a number of renal diseases where properdin is elevated, including hemolytic uremic syndrome, ANCA-associated vasculitis, C3 glomerulopathy, IgA nephropathy, renal transplantation and murine model of acute anti-glomerular basement membrane disease ( 36 45 ). Recently, it has been shown that properdin-deficient MRL/lpr mice have reduced LN, again underscoring the pathogenic relevance of this molecule in this disease ( 46 ). Taken together with its outstanding diagnostic metrics, properdin warrants further study as a disease biomarker and potential therapeutic target in LN.…”
Section: Discussionmentioning
confidence: 94%
“…Not surprisingly, targeting properdin, either genetically or pharmacologically, has been shown to effective in countering a number of renal diseases where properdin is elevated, including hemolytic uremic syndrome, ANCA-associated vasculitis, C3 glomerulopathy, IgA nephropathy, renal transplantation and murine model of acute anti-glomerular basement membrane disease ( 36 45 ). Recently, it has been shown that properdin-deficient MRL/lpr mice have reduced LN, again underscoring the pathogenic relevance of this molecule in this disease ( 46 ). Taken together with its outstanding diagnostic metrics, properdin warrants further study as a disease biomarker and potential therapeutic target in LN.…”
Section: Discussionmentioning
confidence: 94%