Complement-Fixation Tests, Skin Tests, and Experimental Immunization with Antigens of Trypanosoma Cruzi Prepared under Pressure *

Cappa, S. M. González; Schmuñis, Gabriel A.; Traversa, Oscar; Yanovsky, J. F.; Parodi, A. S.

doi:10.4269/ajtmh.1968.17.709

Cited by 37 publications

(7 citation statements)

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“…Many authors have described the immunization of mice against acute Trypanosoma cruzi infection using non-living vaccines prepared by various means (Menezes, 1965;Seneca, Peer & Hampar, 1966;Gonzalez-Cappa, Schmunis, Traversa, Yanovsky & Parodi, 1968;Goble, 1970;Hanson, Chien & Chapman, 1973;Kierszenbaum & Budzko, 1975). In general, the protection obtained has been incomplete and usually required multiple injections of vaccine.…”

Section: Introductionmentioning

confidence: 99%

Corynebacterium parvumas an adjuvant forTrypanosoma cruziepimastigote vaccines: a comparison with saponin andBordetella pertussis

Bomford

McHardy

1979

Parasitology

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SUMMARYThe effect was compared in CBA mice of addingCorynebacterium parvum, saponin, andBordetella pertussisto living or killedTrypanosoma cruzi(Y strain) epimastigote vaccines on the induction of protective immunity against subcutaneous (s.c.) challenge with blood trypomastigotes. The addition ofC. parvumto a low dose ofT. cruzivaccine, which alone was non-protective, generated a greater degree of protection than did saponin orB. pertussis. C. parvumalone increased resistance to infection to a variable and usually weak extent. The addition ofC. parvumto larger doses ofT. cruzivaccine, which were themselves sufficient to elicit some degree of protection, improved resistance when the challenge was given 1 or 12 weeks after immunization, but lowered it at 3 weeks. It is concluded that the comparative efficacy of adjuvants forT. cruzivaccines needs to be assessed on 3 parameters: (1) the dose of antigen, (2) the dose of adjuvant and (3) the time interval between immunization and challenge.

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Section: Introductionmentioning

confidence: 99%

Corynebacterium parvumas an adjuvant forTrypanosoma cruziepimastigote vaccines: a comparison with saponin andBordetella pertussis

Bomford

McHardy

1979

Parasitology

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“…DTH reactions to T. cruzi antigens were shown in vivo in human beings (Mayer andPifano 1941, Tschudi et al 1968) and in the mouse model using crude T. cruzi extracts (Gonzales-Cappa et al 1968), as well as purified T. cruzi antigens, such as the immunodominant SAPA antigen (Nasser et al 1997) and cruzipain (Laderach et al 1996). The DTH responses are mediated by CD4 + T cells, as adoptive transfer of this cell population purified from T. cruzi-infected mice to naïve mice also transferred the ability to mount a local DTH reaction (Hontebeyrie-Joskowicz et al 1987).…”

Section: Delayed-type Hypersensitivity and Cchcmentioning

confidence: 99%

The pathogenesis of Chagas' disease: when autoimmune and parasite-specific immune responses meet

Soares

Pontes-de-Carvalho

Ribeiro-dos-Santos

2001

An. Acad. Bras. Ciênc.

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Chagas' disease is a major health problem in Latin America, where it constitutes one of the leading causes of heart failure. About one fourth of Trypanosoma cruzi-infected individuals develop chronic chagasic cardiomyopathy (CChC), the most severe form of the disease. CChC is histologically characterized by the presence of multifocal inflammatory infiltrates in the heart, composed mainly by mononuclear cells, usually adhered to myocytes and leading to myocytolysis, and frequently by interstitial fibrosis. The pathogenesis of CChC is still unclear, despite intense investigations both in human beings and in animal models of the disease. Although tissue parasitism is rare in the chronic phase of infection, an immune response targeted to persistent parasites or parasite antigens is suggested, by some authors, as the pathogenic mechanism of CChC. Other researchers affirm that the lack of correlation between tissue parasitism and intensity of inflammation suggests, along with the presence of autoreactive immune responses, that CChC results from the action of an autoimmune response. Herein we review reports from the literature and our own data, which together indicate, on one hand, the participation of parasite-specific immune responses and, on the other hand, clearly demonstrate the participation of heart-specific immune responses in the pathogenesis of CChC. Moreover, multiple factors may determine whether an individual in the indeterminate form of the disease will develop CChC. The mechanisms by which T. cruzi breaks immunological tolerance to heart antigens are also discussed.

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“…Delayed-type hypersensitivity has been shown to occur in many microbial, fungal, and protozoal diseases. In protozoal diseases caused by hemoflagellates, delayed-type hypersensitivity has been recently reexamined by Gonzalez-Cappa et al (2) and Seah (6), who studied Trypanosoma cruzi infection, and reviewed by Cahill (1) in leishmaniasis.…”

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confidence: 99%

Cell-Mediated Hypersensitivity in Rabbits Infected with Trypanosoma brucei and Trypanosoma rhodesiense

Tizard

Soltys

1971

Infect Immun

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Animals infected with strains of Trypanosoma brucei and T. rhodesiense exhibited cutaneous hypersensitivity to intradermal administration of antigen. This reactivity was of two types, an Arthus-type, antibody-mediated reaction which reached maximum intensity 4 hr after injection and a delayed-type, cell-mediated reaction which reached maximum intensity 24 hr after injection. This delayed-type hypersensitivity appeared in rabbits not earlier than 3 weeks after onset of infection. It did not occur in animals which received dead organisms. There was a cross-reaction in both types of reactivity between antigens prepared from T. brucei and T. rhodesiense. The delayed-type hypersensitivity was transferred to normal rabbits by intravenous inoculation of washed living cells from the spleen of a rabbit which showed delayed hypersensitivity. Dead cells failed to transfer hypersensitivity. The histological picture of the indurated area was typical of a delayed-type reaction. Recent studies by Mackaness and Blanden (3)

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Complement-Fixation Tests, Skin Tests, and Experimental Immunization with Antigens of Trypanosoma Cruzi Prepared under Pressure *

Cited by 37 publications

References 0 publications

Corynebacterium parvumas an adjuvant forTrypanosoma cruziepimastigote vaccines: a comparison with saponin andBordetella pertussis

Corynebacterium parvumas an adjuvant forTrypanosoma cruziepimastigote vaccines: a comparison with saponin andBordetella pertussis

The pathogenesis of Chagas' disease: when autoimmune and parasite-specific immune responses meet

Cell-Mediated Hypersensitivity in Rabbits Infected with Trypanosoma brucei and Trypanosoma rhodesiense

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