2020
DOI: 10.1007/s00428-020-02800-0
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Complement activation is associated with crescent formation in IgA nephropathy

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Cited by 23 publications
(29 citation statements)
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“…Mostly small descriptive studies found C5b-9 as coarse granules in the glomerulus ( 57 , 58 , 72 , 76 , 81 , 137 , 139 , 143 , 158 , 160 , 161 )—always in the mesangium, sometimes also along the capillary wall ( 19 , 44 , 52 , 67 , 75 , 96 , 97 , 110 , 115 , 124 , 128 , 162 166 ), in one case report only along the capillary wall ( 159 ) —, along Bowman’s capsule ( 52 , 162 , 163 ), as coarse granules ( 19 , 44 , 52 , 57 , 70 , 72 , 75 , 96 , 97 , 110 , 115 , 163 ) or linearly ( 110 , 115 ) along the tubular basement membrane and occasionally on tubular cells ( 110 ), and in the vascular wall ( 19 , 52 , 57 , 67 , 72 , 96 , 110 , 115 , 137 , 162 ). Deposits along the capillary wall were localized in the subepithelial space ( 97 , 164 ).…”
Section: Kidney Diseases Due To Immune Complex Depositionmentioning
confidence: 99%
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“…Mostly small descriptive studies found C5b-9 as coarse granules in the glomerulus ( 57 , 58 , 72 , 76 , 81 , 137 , 139 , 143 , 158 , 160 , 161 )—always in the mesangium, sometimes also along the capillary wall ( 19 , 44 , 52 , 67 , 75 , 96 , 97 , 110 , 115 , 124 , 128 , 162 166 ), in one case report only along the capillary wall ( 159 ) —, along Bowman’s capsule ( 52 , 162 , 163 ), as coarse granules ( 19 , 44 , 52 , 57 , 70 , 72 , 75 , 96 , 97 , 110 , 115 , 163 ) or linearly ( 110 , 115 ) along the tubular basement membrane and occasionally on tubular cells ( 110 ), and in the vascular wall ( 19 , 52 , 57 , 67 , 72 , 96 , 110 , 115 , 137 , 162 ). Deposits along the capillary wall were localized in the subepithelial space ( 97 , 164 ).…”
Section: Kidney Diseases Due To Immune Complex Depositionmentioning
confidence: 99%
“…Individual components of C5b-9 were two times more abundant in patients with than without global mesangial hypercellularity, endocapillary hypercellularity, or moderate to extensive interstitial fibrosis or tubular atrophy but equally abundant in patients with or without glomerulosclerosis ( 124 ). Glomerular deposits were more frequent when capsular adhesion and crescents were present ( 76 ), while those with cellular or fibrocellular crescents had more intense staining ( 166 ). Deposits seemed also more frequent in the glomerulus (27 vs. 12%, p = 0.06) and vascular wall (68 vs. 46%, p = 0.06) when thrombotic microangiopathy was present ( 167 ).…”
Section: Kidney Diseases Due To Immune Complex Depositionmentioning
confidence: 99%
“…This may point to different pathways involved in the pathogenesis of crescentic IgAN, where the level of underglycosylation might be of secondary importance. Previous studies have described differences in the pathogenesis, histology, and presentation between IgAN and IgA vasculitis; regarding the pattern of glomerular deposits, the impact of systemic inflammation, role of complement activation, and disease outcome supporting the above suggestion [ 26 , 27 , 28 ].…”
Section: Discussionmentioning
confidence: 53%
“…In fact, many studies have previously suggested that the local complement system in the glomeruli is activated via the alternative or the mannose-binding lectin (MBL) pathway in IgAN patients. 14,15 In particular, Roos et al reported that activation of the lectin pathway was associated with more severe renal damage in IgAN patients. 14 In their study, complement activation occurred via the alternative pathway in 75% of patients, whereas glomerular deposition of MBL, Lficolin, and C4d, which is indicative of activation of complement via the lectin pathway, was observed in 25% of patients.…”
Section: Introductionmentioning
confidence: 99%
“…Although renal biopsy remains the gold standard for diagnosis, recent efforts have been made to find new biomarkers that might predict the progression and prognosis of IgAN. In fact, many studies have previously suggested that the local complement system in the glomeruli is activated via the alternative or the mannose‐binding lectin (MBL) pathway in IgAN patients 14,15 . In particular, Roos et al .…”
Section: Introductionmentioning
confidence: 99%