E-government is an extremely interesting research field with numerous research (academic) and practical implications. Under this context, the present study proceeds in developing and testing an original conceptual framework that explores the factors influencing the use of e-government services. The proposed conceptual framework was tested using a newly developed structured questionnaire in a sample of 282 Greek internet users. Hypothesis testing was conducted using the structural equation modeling (SEM) technique. Results underline, among others, the significance of (1) perceived compatibility, (2) perceived operational benefits, (3) trust in e-government services, and (4) perceived information in enhancing the intention of citizens to use e-government services.