Competitive Binding Between Id1 and E2F1 to Cdc20 Regulates E2F1 Degradation and Thymidylate Synthase Expression to Promote Esophageal Cancer Chemoresistance

Li, Bin; Xu, Wen; Guan, Xin Yuan; Qin, Yan; Law, Simon; Lee, Nikki Pui Yue; Chan, Kin; Tam, Pui Ying; Li, Yuk Yin; Chan, Kwok Wah; Yuen, Hiu Fung; Tsao, Sai Wah; He, Qing-Yu; Cheung, Any

doi:10.1158/1078-0432.ccr-15-1196

Cited by 54 publications

(55 citation statements)

References 39 publications

(39 reference statements)

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“…The qRT-PCR was performed as described previously [51]. In brief, total RNA was isolated using Trizol reagent according to the manufacturer's protocol (Invitrogen).…”

Section: Methodsmentioning

confidence: 99%

Significance of PI3K/AKT signaling pathway in metastasis of esophageal squamous cell carcinoma and its potential as a target for anti-metastasis therapy

Lam

et al. 2017

Oncotarget

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Metastasis is the most lethal hallmark of esophageal squamous cell carcinoma (ESCC). The aim of the study is to identify key signaling pathways that control metastasis in ESCC. Highly invasive ESCC sublines (designated I3 cells) were established through three rounds of selection of cancer cells invading through matrigel-coated chambers. Gene expression profile of one of the I3 sublines was compared with that of its parental cell line using cDNA microarray analysis. Gene ontology and pathway analyses of the differentially expressed genes (both upregulated and downregulated) indicated that genes associated with cellular movement and the AKT pathway were associated with increased cancer cell invasiveness. Western blot analysis confirmed increased phosphorylated AKT (p-AKT), N-cadherin and decreased E-cadherin expression in the I3 cells. Immunohistochemistry was used to evaluate the clinical significance of p-AKT expression in ESCC, and the results showed higher p-AKT nuclear expression in lymph node metastases when compared with primary carcinoma. Inactivation of the PI3K/AKT pathway with specific inhibitors, or with PTEN overexpression, resulted in reversed cadherin switching and inhibited cancer cell motility. Inhibition of the pathway by treatment with wortmannin markedly suppressed experimental metastasis in nude mice. Our data demonstrated the importance of the PI3K/AKT signaling pathway in ESCC metastasis and support PI3K/AKT as a valid therapeutic target in treatment of metastatic ESCC.

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“…The qRT-PCR was performed as described previously [51]. In brief, total RNA was isolated using Trizol reagent according to the manufacturer's protocol (Invitrogen).…”

Section: Methodsmentioning

confidence: 99%

Significance of PI3K/AKT signaling pathway in metastasis of esophageal squamous cell carcinoma and its potential as a target for anti-metastasis therapy

Lam

et al. 2017

Oncotarget

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“…It is also known to be induced by Stat3 and then up-regulates MDM2 to promote p53 protein degradation (16). Moreover, ID1 increases thymidylate synthase dependent upon E2F1 to promote cancer chemoresistance (12). These findings indicate that ID1 expression associates with other molecular markers and may not be an independent prognostic factor.…”

Section: Discussionmentioning

confidence: 99%

“…A recent study revealed that competitive binding between ID1 and E2F1 to CDC20 regulates E2F1 degradation and thymidylate synthase expression to promote esophageal cancer chemoresistance (12). Moreover, another previous study showed that ID1 was also induced by nicotine, and ectopic expression of ID1 might enhance cell resistance to damage (13).…”

Section: Discussionmentioning

confidence: 99%

“…A recent study reported that competitive binding between ID1 and E2F1 to Cdc20 regulates E2F1 degradation and thymidylate synthase expression to promote esophageal cancer chemoresistance. The ID1-E2F1-IGF2 regulatory axis has important implications for cancer prognosis and treatment (12). These data indicate that ID1 is up-regulated by chemotherapeutic drugs and may be involved in chemoresistance.…”

mentioning

confidence: 95%

“…The overexpression of ID1 is frequent (93%) in human primary ESCC (10). ID1 expression correlates directly with tumor invasion, metastasis, and poor prognosis in ESCC (6,11,12). Notably, ID1 was involved in chemotherapy and radiotherapy resistance in human cancers including pancreatic adenocarcinoma, breast cancer, lung cancer, colorectal cancer, and esophageal cancer and becomes a new potential therapeutic target (13)(14)(15)(16)(17).…”

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confidence: 99%

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Inhibitor of Differentiation/DNA Binding 1 (ID1) Inhibits Etoposide-induced Apoptosis in a c-Jun/c-Fos-dependent Manner

Zhao

Luo

et al. 2016

Journal of Biological Chemistry

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Esophageal cancer remains one of the most virulent malignancies with ranking eighth in incidence and sixth in cancerrelated mortality worldwide (1). These malignancies are particularly prevalent in China and other countries in Asia, where esophageal squamous cell carcinoma (ESCC) 3 is most common (1). A 5-year overall survival rate has not been improved evidently despite the progressed surgical techniques and incorporation of new therapeutic approaches in the past decades (2).

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New insights into the interplay between long non‐coding RNAs and RNA‐binding proteins in cancer

Yao

Yang

Sun

et al. 2022

Cancer Communications

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103

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With the development of proteomics and epigenetics, a large number of RNAbinding proteins (RBPs) have been discovered in recent years, and the interaction between long non-coding RNAs (lncRNAs) and RBPs has also received increasing attention. It is extremely important to conduct in-depth research on the lncRNA-RBP interaction network, especially in the context of its role in the occurrence and development of cancer. Increasing evidence has demonstrated that lncRNA-RBP interactions play a vital role in cancer progression; therefore, targeting these interactions could provide new insights for cancer drug discovery. In this review, we discussed how lncRNAs can interact with RBPs to regulate their localization, modification, stability, and activity and discussed the effects of RBPs on the stability, transport, transcription, and localization of lncRNAs. Moreover, we explored the regulation and influence of these interactions on lncRNAs, RBPs, and downstream pathways that are related to cancer development, such as N6-methyladenosine (m6A) modification of lncRNAs.In addition, we discussed how the lncRNA-RBP interaction network regulates cancer cell phenotypes, such as proliferation, apoptosis, metastasis, drug resistance, immunity, tumor environment, and metabolism. Furthermore, we summarized the therapeutic strategies that target the lncRNA-RBP interaction network. Although these treatments are still in the experimental stage and various theories and processes are still being studied, we believe that these strategies may provide new ideas for cancer treatment.

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Competitive Binding Between Id1 and E2F1 to Cdc20 Regulates E2F1 Degradation and Thymidylate Synthase Expression to Promote Esophageal Cancer Chemoresistance

Cited by 54 publications

References 39 publications

Significance of PI3K/AKT signaling pathway in metastasis of esophageal squamous cell carcinoma and its potential as a target for anti-metastasis therapy

Significance of PI3K/AKT signaling pathway in metastasis of esophageal squamous cell carcinoma and its potential as a target for anti-metastasis therapy

Inhibitor of Differentiation/DNA Binding 1 (ID1) Inhibits Etoposide-induced Apoptosis in a c-Jun/c-Fos-dependent Manner

New insights into the interplay between long non‐coding RNAs and RNA‐binding proteins in cancer

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