New insights into the interplay between long non‐coding RNAs and RNA‐binding proteins in cancer

Abstract

With the development of proteomics and epigenetics, a large number of RNAbinding proteins (RBPs) have been discovered in recent years, and the interaction between long non-coding RNAs (lncRNAs) and RBPs has also received increasing attention. It is extremely important to conduct in-depth research on the lncRNA-RBP interaction network, especially in the context of its role in the occurrence and development of cancer. Increasing evidence has demonstrated that lncRNA-RBP interactions play a vital role in cancer progression; therefore, targeting these interactions could provide new insights for cancer drug discovery. In this review, we discussed how lncRNAs can interact with RBPs to regulate their localization, modification, stability, and activity and discussed the effects of RBPs on the stability, transport, transcription, and localization of lncRNAs. Moreover, we explored the regulation and influence of these interactions on lncRNAs, RBPs, and downstream pathways that are related to cancer development, such as N6-methyladenosine (m6A) modification of lncRNAs.In addition, we discussed how the lncRNA-RBP interaction network regulates cancer cell phenotypes, such as proliferation, apoptosis, metastasis, drug resistance, immunity, tumor environment, and metabolism. Furthermore, we summarized the therapeutic strategies that target the lncRNA-RBP interaction network. Although these treatments are still in the experimental stage and various theories and processes are still being studied, we believe that these strategies may provide new ideas for cancer treatment.

Long non-coding RNA DDX11-AS1 promotes the proliferation and migration of glioma cells by combining with HNRNPC

“…Interestingly, many researchers have recently found that the interaction between lncRNAs and RBPs plays a key role in tumor progression, 30 and most lncRNAs can interact with one or more RBPs. 31 Here, we first predicted the potential protein targets of DDX11-AS1 using the starBase v.2.0 website and then detected the proteins bound by DDX11-AS1 in glioma cells by CHIRP-MS.…”

Progress and application of epitranscriptomic m 6 A modification in gastric cancer

“…ncRNAs can also interact with RNA-binding proteins, including m 6 A regulators, to regulate cancer cell phenotypes [ 101 ]. Zhu et al [ 102 ] reported that the lncRNA ARHGAP5-AS1 can recruit METTL3 to facilitate methylation of ARHGAP5 , which stabilizes ARHGAP5 in the cytoplasm.…”

LncRNAs and CircRNAs in cancer

“…17,18 LncRNAs mainly affect cancer progression by binding and interacting with RNAs, DNAs, and proteins. 19 The regulatory role of lncRNAs in tumors is also related to their localization, sequence, and secondary structure. 20 LncRNAs exert their regulatory roles in cells through a variety of mechanisms (Figure 1).…”