Competition of Antigens*

Adler, Frank L.

doi:10.1159/000391362

Cited by 21 publications

(27 citation statements)

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“…5) . 29 Present evidence supports the concept that humoral antibody regulates the population of antibody-producing cells by combination with antigen at some level.3O This is unlikely to occur in situ in the peritoneal cavity, for it has been shown that, in as short a period as 3 hr. following intraperitoneal injection, aggregated human gamma globulin may be detected in considerable quantity in the reticuloendothelial system.3l…”

Section: Discussionsupporting

confidence: 76%

Influence of human rheumatoid factor on numbers of antibody‐producing cells

Brown¹,

Epstein²

1969

Arthritis & Rheumatism

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whether the macroglobulins having antiIgG specificity (rheumatoid factors) that occur spontaneously during the course of human peripheral rheumatoid arthritis could similarly influence an immune response to human IgG. To date, no homeostatic function has been demonstrated for this group of macroglobulins, which occur with such regularity and in such high concentrations in the course of this disease. In the present investigation, human IgM rheumatoid factor is shown to decrease the number of mouse spleen cells making antibody after a single injection of human IgG as measured by the immunocytoadherence technic.

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Section: Discussionsupporting

confidence: 76%

Influence of human rheumatoid factor on numbers of antibody‐producing cells

Brown¹,

Epstein²

1969

Arthritis & Rheumatism

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“…In the doses used CoF was nontoxic in vivo (14,26) and it had no cytotoxic action on cultured murine spleen cells during 48 h in vitro? That CoF suppressed secondary as well as primary responses argues against antigenic competition as a possible mode of action, since competition is a feature only of primary responses (34,35). In mice suitably preimmunized with CoF its suppressive effect on antibody production was prevented, whereas previous active immunization with the dominant antigen of a competing pair generally enhances rather than abolishes subsequent competition (35).…”

Section: Discussionmentioning

confidence: 99%

Role of Complement in Induction of Antibody Production in Vivo

Pepys

1974

The Journal of Experimental Medicine

310

108

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There has been considerable recent progress in understanding of the mechanisms involved in cooperation between T and B lymphocytes in the induction of humoral antibody formation (see for example 1), but much still remains to be learned. The discovery of an interaction between lymphocytes and the fixed C3 component of complement (2-5), and the demonstration by Nussenzweig et al. that C3 receptors are a feature of B-cell populations (6-10), raise the possibility that C3 might play a part in this process (11). Germinal centers of lymphoid tissue, in which the induction of antibody production m a y occur, contain B cells, fixed C3, and complexes capable of fixing C3 (12). I have previously shown that treatment of mice in vivo with the C3-cleaving protein of cobra venom (CoF) 1 suppresses thymus-dependent but not thymus-independent antibody production, suggesting a possible role for C3 in lymphocyte cooperation (11).

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“…It is well known that the simultaneous presentation of two antigens may result in a decrease in the amount of antibody formed to one or both antigens. Previous studies on this phenomenon, generally referred to as "antigenic competition," have been extensively reviewed by Adler (1,2). The mechanism of antigenic competition is still unknown.…”

Section: (From the Department Of Medicine New York University Schoolmentioning

confidence: 99%

Studies on the Control of Antibody Synthesis

Brody

Walker

Siskind

1967

The Journal of Experimental Medicine

105

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In the system studied, antigenic competition between two haptenic determinants was found to be of the same extent whether the haptens were on the same or on separate carrier molecules. Suppression of antibody formation to one determinant by administration of passive antibody partially eliminated the depressive effects of antigenic competition when the two haptens were located on separate carrier molecules but had no effect on antibody production to the second hapten when the two determinants were present on the same molecule. The results are discussed in terms of the mechanisms of suppression, antigenic competition, and control of antibody formation.

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Competition of Antigens*

Cited by 21 publications

References 0 publications

Influence of human rheumatoid factor on numbers of antibody‐producing cells

Influence of human rheumatoid factor on numbers of antibody‐producing cells

Role of Complement in Induction of Antibody Production in Vivo

Studies on the Control of Antibody Synthesis

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