Competition at the Mouse t Complex: Rare Alleles Are Inherently Favored

Boven, Michiel van; Weissing, Franz J.

doi:10.1006/tpbi.2001.1551

Cited by 15 publications

(9 citation statements)

References 40 publications

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“…Although epistatic interactions influencing TRD have been reported [6,36,37], the current data reports an independent modifier that is not located in a region of statistically significant distortion yet has a striking effect on the Chr 11 TRD. Transmission ratio distortion on Chr 11 is increased among backcross progeny homozygous for A/J genotypes on Chr 3 suggesting a maladaptive incompatibility between Chr 3 AA and Chr 11 AA .…”

Section: Discussioncontrasting

confidence: 57%

Genetic mapping and developmental timing of transmission ratio distortion in a mouse interspecific backcross

et al. 2010

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BackgroundTransmission ratio distortion (TRD), defined as statistically significant deviation from expected 1:1 Mendelian ratios of allele inheritance, results in a reduction of the expected progeny of a given genotype. Since TRD is a common occurrence within interspecific crosses, a mouse interspecific backcross was used to genetically map regions showing TRD, and a developmental analysis was performed to identify the timing of allele loss.ResultsThree independent events of statistically significant deviation from the expected 50:50 Mendelian inheritance ratios were observed in an interspecific backcross between the Mus musculus A/J and the Mus spretus SPRET/EiJ inbred strains. At weaning M. musculus alleles are preferentially inherited on Chromosome (Chr) 7, while M. spretus alleles are preferentially inherited on Chrs 10 and 11. Furthermore, alleles on Chr 3 modify the TRD on Chr 11. All TRD loci detected at weaning were present in Mendelian ratios at mid-gestation and at birth.ConclusionsGiven that Mendelian ratios of inheritance are observed for Chr 7, 10 and 11 during development and at birth, the underlying causes for the interspecific TRD events are the differential post-natal survival of pups with specific genotypes. These results are consistent with the TRD mechanism being deviation from Mendelian inheritance rather than meiotic drive or segregation distortion.

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Section: Discussioncontrasting

confidence: 57%

Genetic mapping and developmental timing of transmission ratio distortion in a mouse interspecific backcross

et al. 2010

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“…One can also compute the conditions for the successful invasion of novel alleles into this steady state Van Boven and Weissing 2001). In the Appendix, we derive that a novel, i.e., the n+1 th , allele will invade into a steady state polymorphism of n established alleles whenever it has a fitness contribution of…”

Section: Equilibrium Resultsmentioning

confidence: 99%

“…This shows that MHC alleles with a too low fitness contribution f i cannot persist at equilibrium. Note that this condition for persistence is independent of the choice of l and the basis fitness value b Van Boven and Weissing 2001).…”

Section: Appendixmentioning

confidence: 99%

Heterozygote advantage fails to explain the high degree of polymorphism of the MHC

et al. 2004

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Major histocompatibility (MHC) molecules are encoded by extremely polymorphic genes and play a crucial role in vertebrate immunity. Natural selection favors MHC heterozygous hosts because individuals heterozygous at the MHC can present a larger diversity of peptides from infectious pathogens than homozygous individuals. Whether or not heterozygote advantage is sufficient to account for a high degree of polymorphism is controversial, however. Using mathematical models we studied the degree of MHC polymorphism arising when heterozygote advantage is the only selection pressure. We argue that existing models are misleading in that the fitness of heterozygotes is not related to the MHC alleles they harbor. To correct for this, we have developed novel models in which the genotypic fitness of a host directly reflects the fitness contributions of its MHC alleles. The mathematical analysis suggests that a high degree of polymorphism can only be accounted for if the different MHC alleles confer unrealistically similar fitnesses. This conclusion was confirmed by stochastic simulations, including mutation, genetic drift, and a finite population size. Heterozygote advantage on its own is insufficient to explain the high population diversity of the MHC.

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“…However, these assays cannot work on a broad range of any one rice sample and predictions made from the results are not of high accuracy. Moreover, with some genotypes segregation distortion would be generated by the genes that reduce the viability of zygote (Schimenti, 2000;van Boven and Weissing, 2001). Previous studies on genetic analysis have shown that the gene or quantitative trait loci (QTL) for aroma and cooked kernel elongation (CKE) are linked and present on chromosome 8 (Ahn et al 1993).…”

Section: Discussionmentioning

confidence: 99%

Genetic analysis and gene fine mapping of aroma in rice (Oryza sativa L. Cyperales, Poaceae)

Sun

Gao

et al. 2008

Genet. Mol. Biol.

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We investigated inheritance and carried out gene fine mapping of aroma in crosses between the aromatic elite hybrid rice Oryza sativa indica variety Chuanxiang-29B (Ch-29B) and the non-aromatic rice O. sativa indica variety R2 and O. sativa japonica Lemont (Le). The F 1 grains and leaves were non-aromatic while the F 2 non-aroma to aroma segregation pattern was 3:1. The F 3 segregation ratio was consistent with the expected 1:2:1 for a single recessive aroma gene in Ch-29B. Linkage analysis between simple sequence repeat (SSR) markers and the aroma locus for the aromatic F 2 plants mapped the Ch-29B aroma gene to a chromosome 8 region flanked by SSR markers RM23120 at 0.52 cM and RM3459 at 1.23 cM, a replicate F 2 population confirming these results. Three bacterial artificial chromosome (BAC) clones cover chromosome 8 markers RM23120 and RM3459. Our molecular mapping data from the two populations indicated that the aroma locus occurs in a 142.85 kb interval on BAC clones AP005301 or AP005537, implying that it might be the same gene reported by Bradbury et al (2005a; Plant Biotec J. 3:363-370). The flanking markers Aro7, RM23120 and RM3459 identified by us could greatly accelerate the efficiency and precision of aromatic rice breeding programs.

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Competition at the Mouse t Complex: Rare Alleles Are Inherently Favored

Cited by 15 publications

References 40 publications

Genetic mapping and developmental timing of transmission ratio distortion in a mouse interspecific backcross

Genetic mapping and developmental timing of transmission ratio distortion in a mouse interspecific backcross

Heterozygote advantage fails to explain the high degree of polymorphism of the MHC

Genetic analysis and gene fine mapping of aroma in rice (Oryza sativa L. Cyperales, Poaceae)

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