Competency of Anopheles stephensi mysorensis strain for Plasmodium vivax and the role of inhibitory carbohydrates to block its sporogonic cycle

Basseri, Hamid Reza; Doosti, Sara; Akbarzadeh, Kamran; Nateghpour, Mehdi; Whitten, Miranda M. A.; Ladoni, H

doi:10.1186/1475-2875-7-131

Cited by 23 publications

(17 citation statements)

References 20 publications

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“…stephensi was the most dominant species. This species has been recognized as a chief malaria vector in southern Iran [10, 15] and recently it has been shown that this species has high fitness to transmit Plasmodium vivax in Baluchestan area [26]. Previous studies in India also showed that this species plays a major role in malaria transmission in continental India because of its predominantly domestic habits and its behavior [27].…”

Section: Discussionmentioning

confidence: 99%

Seasonal Abundance and Host-Feeding Patterns of Anopheline Vectors in Malaria Endemic Area of Iran

Basseri

Ahmad

Khakha

et al. 2010

Journal of Parasitology Research

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Seasonal abundance and tendency to feed on humans are important parameters to measure for effective control of malaria vectors. The objective of this study was to describe relation between feeding pattern, abundance, and resting behavior of four malaria vectors in southern Iran. This study was conducted in ten indicator villages (based on malaria incidence and entomological indices) in mountainous/hilly and plain regions situated south and southeastern Iran. Mosquito vectors were collected from indoor as well as outdoor shelters and the blood meals were examined by ELISA test. Over all 7654 female Anopheles spp. were captured, the most common species were Anopheles stephensi, An. culicifacies, An. fluviatilis, and An. d'thali. The overall human blood index was 37.50%, 19.83%, 16.4%, and 30.1% for An. fluviatilis, An. stephensi, An. culicifacies, and An. d'thali, respectively. In addition, An. fluviatilis fed on human blood during the entire year but the feeding behavior of An. stephensi and An. culicifacies varied according to seasons. Overall, the abundance of the female mosquito positive to human blood was 4.25% per human shelter versus 17.5% per animal shelter. This result indicates that the vectors had tendency to rest in animal shelters after feeding on human. Therefore, vector control measure should be planned based on such as feeding pattern, abundance, and resting behavior of these vectors in the area.

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Section: Discussionmentioning

confidence: 99%

Seasonal Abundance and Host-Feeding Patterns of Anopheline Vectors in Malaria Endemic Area of Iran

Basseri

Ahmad

Khakha

et al. 2010

Journal of Parasitology Research

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“…An. stephensi has been experimentally infected with P. vivax from infected monkeys (Basseri et al, 2008;Collins et al, 2009) and humans (Adak et al, 2005); both oocysts and sporozoites found were found in the mosquitoes.…”

Section: Continuedmentioning

confidence: 99%

The Global Public Health Significance of Plasmodium vivax

Battle

Gething

Elyazar

et al. 2012

Advances in Parasitology

112

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“…Suleman et al [37] demonstrated intra-specific variation in the reproductive capacity of A. stephensi but there was no evidence that this species constituted a species complex. The mysorensis form of this species has been recognized as the main vector of malaria in southeastern Iran [38]–[39], while in India it is considered to be a rural species with poor vectorial capacity for both vivax and falciparum malaria. In contrast, the type form is recognized as an efficient vector of urban malaria in India [32].…”

Section: Introductionmentioning

confidence: 99%

Comparative Susceptibility of Different Biological Forms of Anopheles stephensi to Plasmodium berghei ANKA Strain

et al. 2013

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BackgroundThere are varying degrees of compatibility between malaria parasite-mosquito species, and understanding this compatibility may be crucial for developing effective transmission-blocking vaccines. This study investigates the compatibility of different biological forms of a malaria vector, Anopheles stephensi, to Plasmodium berghei ANKA strain.MethodsSeveral biologically different and allopatric forms of A. stephensi were studied. Three forms were isolated from different regions of southern Iran: the variety mysorensis, the intermediate form and the native type form, and an additional type form originated from India (Beech strain).The mosquitoes were experimentally infected with P. berghei to compare their susceptibility to parasitism. Anti-mosquito midgut antiserum was then raised in BALB/cs mice immunized against gut antigens from the most susceptible form of A. stephensi (Beech strain), and the efficacy of the antiserum was assessed in transmission-blocking assays conducted on the least susceptible mosquito biological form.ResultsThe susceptibility of different biological forms of A. stephensi mosquito to P. berghei was specifically inter-type varied. The Beech strain and the intermediate form were both highly susceptible to infection, with higher oocyst and sporozoite infection rates than intermediate and mysorensis forms. The oocyst infection, and particularly sporozite infection, was lowest in the mysorensis strain. Antiserum raised against midgut proteins of the Indian Beech type form blocked infection in this mosquito population, but it was ineffective at blocking both oocyst and sporozoite development in the permissive but geographically distant intermediate form mosquitoes. This suggests that a strong degree of incompatibility exists between the mosquito strains in terms of midgut protein(s) acting as putative ookinete receptors.ConclusionsThe incompatibility in the midgut protein profiles between two biological forms of A. stephensi demonstrates a well-differentiated population structure according to geographical origin. Therefore, the design of potential transmission-blocking strategies should incorporate a more thorough understanding of intra-species variations in host-parasite interactions.

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Competency of Anopheles stephensi mysorensis strain for Plasmodium vivax and the role of inhibitory carbohydrates to block its sporogonic cycle

Cited by 23 publications

References 20 publications

Seasonal Abundance and Host-Feeding Patterns of Anopheline Vectors in Malaria Endemic Area of Iran

Seasonal Abundance and Host-Feeding Patterns of Anopheline Vectors in Malaria Endemic Area of Iran

The Global Public Health Significance of Plasmodium vivax

Comparative Susceptibility of Different Biological Forms of Anopheles stephensi to Plasmodium berghei ANKA Strain

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