Compensatory lung growth occurs in adult dogs after right pneumonectomy.

Abstract

We investigated the structural changes in the left lung of five adult male foxhounds 5 mo (n = 2) or 16 mo (n = 3) after right pneumonectomy (-54% of lung resected) and five sex-and age-matched foxhounds 15-16 mo after right thoracotomy without pneumonectomy. Lungs were fixed by intratracheal instillation of glutaraldehyde and analyzed by standard morphometric techniques. After right pneumonectomy, volume of the left lung increased by 72%. Volumes of all septal structures increased significantly and were more pronounced at 5 than at 16 mo after pneumonectomy. At 16 mo, the relative increases in volume with respect to the control left lung were as follows: epithelium 73%, interstitium 100%, endothelium 55%, and capillary blood volume 43%. Surface areas of alveoli and capillary increased significantly by 52% and 34%, respectively. At 5 mo after pneumonectomy, harmonic mean thickness of the tissueplasma barrier was significantly greater but at 16 mo it was not different from controls. There was a significant increase in diffusing capacity for oxygen (33% above controls) at 16 mo after pneumonectomy. These data suggest that, in contrast to previous findings after left pneumonectomy, compensatory lung growth does occur in adult dogs after resection of > 50% of lung. (J. Clin. Invest. 1994. 94:405-412.)

An Official Research Policy Statement of the American Thoracic Society/European Respiratory Society: Standards for Quantitative Assessment of Lung Structure

“…This is a variant of SURS useful in the study of large lungs, where heterogeneity is suspected, or in studies that affect only part of the lung (93). The lung is divided into strata of similar or very different size (e.g., left and right lower and upper lobes); each stratum is serially sliced at equal thickness with a random start in the first cut ( Figure 2).…”

Compensatory Lung Growth After Pneumonectomy

“…Development of sophisticated morphometric methods has permitted accurate analysis of lung volume and alveolar number, and studies indicate that new alveoli are formed during post-pneumonectomy CLG Sakamaki, et al, 2002). In dogs, however, it appears that the CLG response is initiated after a certain threshold is achieved (removal of >50% of total lung mass) (Hsia, et al, 1994). Bronchoalveolar stem cells (BASC) have also been implicated in CLG.…”

Avaliação hemogasométrica em cães submetidos à pneumonectomia esquerda

“…Entretanto, verificou-se que, nos momentos seguintes, a PaO 2 já retornava a valores do intervalo fisiológico para, no T36d, não mais apresentar diferenças significativas em relação ao T0. Estes resultados corroboram com os obtidos por Carlin et al (1991), Hsia et al (1994) e Takeda et al (1999) no pós-operatório mediato. Esta hipoxemia momentânea verificada uma hora após a extubação pode estar relacionada a diferentes fatores.…”

“…Estes resultados vêm ao encontro daqueles descritos por Carlin et al (1991), Hsia et al (1994) e Takeda et al (1999) no pós-operatório mediato, como já ressaltado no segundo parágrafo da discussão.…”