Compensatory function of submandibular gland in mice with streptozotocin diabetes under conditions of transplantation

Gvazava, I. G.; Vasiliev, A. V.; Balan, O. V.

doi:10.1007/s10517-012-1610-2

Cited by 1 publication

(1 citation statement)

References 13 publications

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“…Most likely, the submandibular glands were the ones most affected by the atropine and it cannot be ruled out that compensatory saliva production started from the parotid glands. Such compensatory salivary production has been found in animal studies.…”

Section: Discussionsupporting

confidence: 55%

Sublingual administration of atropine eyedrops in children with excessive drooling – a pilot study

Norderyd

Graf

Marcusson

et al. 2015

Int J Paed Dentistry

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BackgroundDrooling can be a severe disability and have high impact on daily life. Reversible treatment is preferable.AimTo analyse whether sublingual administration of atropine eyedrops is a useful reversible treatment option for severe drooling in children with disabilities.DesignThe study had a prospective, single‐system research design. The participants served as their own controls. The study period was 3 weeks without treatment, 4 weeks with atropine eyedrop solution 10 mg/mL one drop a day followed by 4 weeks of one drop twice a day. Parents’ rating of their child's drooling was assessed on a 100‐mm VAS, and unstimulated salivary secretion rate measurement was performed together with notations about side effects and practicality.ResultsParents’ VAS assessment of drooling decreased from a median (range) of 74 (40–98) at baseline to 48 (18–88) (P = 0.05) and 32 (12–85) (P = 0.004) after 4 weeks of atropine once a day and another 4 weeks of atropine twice a day, respectively (n = 11). Unstimulated salivary secretion rates decreased from baseline to end of study (P = 0.032). Several parents complained about difficult administration. No irreversible side effects were noted.ConclusionsSublingual atropine eyedrops may be an alternative for treatment of severe drooling in children with disabilities.

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Section: Discussionsupporting

confidence: 55%