Compensated hypogonadism in men with sickle cell disease

Abstract

Sickle cell disease (SCD) is a relatively common genetic disease and comprises a group of disorders characterized by the presence of at least one haemoglobin S. 1 The sickle gene mutation is common in sub-Saharan Africa and other parts of the world, and it is estimated that more than 300 000 children are born each year with SCD, about two-thirds of them in Africa. 2 SCD has been recognized as a public health issue and a neglected problem by several key agencies, including the United Nations (UN) and the World Health Organization

Perfil Hormonal E Hipogonadismo De Pessoas Com Doença Falciforme Acompanhadas Em Um Centro Especializado Na Cidade De Feira De Santana-Ba

“…Embora haja pouco esclarecimento atualmente sobre a causa do hipogonadismo nessa população, nossos números representam um importante achado para o seu entendimento (RIBEIRO et al, 2021), visto que a maioria dos pacientes apresentou o hipogonadismo compensado, enquanto nenhum deles apresentou o hipogonadismo primário e apenas dois se enquadraram no hipogonadismo secundário.…”

Incidence and predictors of priapism events in sickle cell anemia: a diary-based analysis

“…The high prevalence of compensated hypogonadism is similar to what was reported in another study in Brazil. 11 An unanticipated finding was the high prevalence of chronic kidney disease and short-term mortality occurring in men with a history of priapism. Without a comparison group followed prospectively, we could not determine an association between recurrent priapism and renal disease.…”

“…We defined gonadal function as follows: eugonadism with testosterone ≥300 ng/dL and LH ≤ 9.4 mUI/mL; primary hypogonadism with testosterone <300 ng/dL and LH > 9.4 mUI/mL; secondary hypogonadism with testosterone <300 ng/dL and LH ≤ 9.4 mUI/ mL; and compensated hypogonadism as testosterone ≥300 ng/dL and LH > 9.4 mUI/mL. 11…”

Sickle Cell Disease

“…Male reproductive health problems are common in people with SCD, with as much as 24% developing hypogonadism, a syndrome of low testosterone, infertility, erectile dysfunction, and poor libido . Sperm abnormalities may occur in as much as 90% of men with SCD, thought to be secondary to testicular infarction or hypogonadism.…”