Compatibility Study of Danggui Buxue Tang on Chemical Ingredients, Angiogenesis and Endothelial Function

Lin, Ping-Lan; Li, Zhicheng; Xie, Rui-Fang; Wang, Youhua; Zhou, Xin

doi:10.1038/srep45111

Cited by 14 publications

(9 citation statements)

References 14 publications

(14 reference statements)

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“…Radix A. sinensis contains angiogenetic modulators such as polysaccharides, ferulic acid, calycosin and calycosin-7-glucoside that may function in angiogenesis and recovery of endothelial dysfunction. 33,34 In our study the functional compound BP derived from Radix A. sinensis exerted antiangiogenetic activity through downregulating VEGF, VEGFR1 and VEGFR2 expression in tumor tissue ( Figure 1E and F). BP is known to suppress human umbilical vein endothelial cell proliferation, migration and capillary tube formation via the activation of p38 and ERK 1/2.…”

Section: Discussionmentioning

confidence: 54%

Encapsulated n-Butylidenephthalide Efficiently Crosses the Blood–Brain Barrier and Suppresses Growth of Glioblastoma

Lin¹,

Huang²,

Chang³

et al. 2020

IJN

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Background: n-Butylidenephthalide (BP) has anti-tumor effects on glioblastoma. However, the limitation of BP for clinical application is its unstable structure. A polycationic liposomal polyethylenimine (PEI) and polyethylene glycol (PEG) complex (LPPC) has been developed to encapsulate BP for drug structure protection. The purpose of this study was to investigate the anti-cancer effects of the BP/LPPC complex on glioblastoma in vitro and in vivo. Methods: DBTRG-05MG tumor bearing xenograft mice were treated with BP and BP/ LPPC and then their tumor sizes, survival, drug biodistribution were measured. RG2 tumor bearing F344 rats also treated with BP and BP/LPPC and then their tumor sizes by magnetic resonance imaging for evaluation blood-brain barrier (BBB) across and drug therapeutic effects. After treated with BP/LPPC in vitro, cell uptake, cell cycle and apoptotic regulators were analyzed for evaluation the therapeutic mechanism. Results: In athymic mice, BP/LPPC could efficiently suppress tumor growth and prolong survival. In F334 rats, BP/LPPC crossed the BBB and led to tumor shrinkage. BP/LPPC promoted cell cycle arrest at the G 0 /G 1 phase and triggered the extrinsic and intrinsic cell apoptosis pathways resulting cell death. BP/LPPC also efficiently suppressed VEGF, VEGFR1, VEGFR2, MMP2 and MMP9 expression. Conclusion: BP/LPPC was rapidly and efficiently transported to the tumor area across the BBB and induced cell apoptosis, anti-angiogenetic and anti-metastatic effects in vitro and in vivo.

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Section: Discussionmentioning

confidence: 54%

Encapsulated n-Butylidenephthalide Efficiently Crosses the Blood–Brain Barrier and Suppresses Growth of Glioblastoma

Lin¹,

Huang²,

Chang³

et al. 2020

IJN

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“…Studies have shown that the five chemical components can be absorbed into the plasma [ 9 ] through small intestine [ 10 ] and are related to vascular remodeling factors. Both ferulic acid and calycosin-7-glucoside could improve endothelium dysfunction in dose dependence [ 11 ]. Formononetin has a suppressive effect on PDGF-BB-stimulated VSMCs proliferation and migration, which occur partly via the inhibition of Akt signaling pathway [ 12 ].…”

Section: Methodsmentioning

confidence: 99%

Inhibition of Aortic Intimal Hyperplasia and Vascular Smooth Muscle Proliferation and Extracellular Matrix Protein Expressions by Astragalus–Angelica Combination

Yan

Peng

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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VSMC proliferation and ECM deposition always resulted in intimal hyperplasia. Astragalus–Angelica combination has a protective effect on the cardiovascular system. The inhibition effect of different Astragalus–Angelica combination on the hyperplastic intima after vascular balloon injury in rats was investigated in this study. Astragalus–Angelica combination can inhibit the intima hyperplasia after balloon injury, in which a 1:1 ratio shows excellent results. Astragalus–Angelica combination can enhance the expression of smooth muscle α-actin (SMа-actin) and inhibit the expression of proliferating cell nuclear antigen (PCNA), cyclin D1, cyclin E, collagen I (Col-I), fibronectin (FN), and matrix metallopeptidase-9 (MMP-9) in hyperplastic intima, suggesting that Astragalus–Angelica combination can inhibit the intimal hyperplasia of blood vessels in rats. The mechanism is related to the inhibition of PI3K/Akt signaling pathway activation and thereby inhibits the phenotypic transformation and cell proliferation of VSMCs and thus inhibits the extracellular matrix (ECM) deposition of vascular wall during intimal hyperplasia.

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“…Danggui Buxue Tang (DBT) is a classic Chinese herbal formula which consists of Astragali mongholici Radix and Angelica sinensis Radix (ASR). DBT may enhance angiogenesis and relieve endothelial dysfunction induced by lysophosphatidyl choline ( Lin et al, 2017 ).…”

Section: Chinese Herbal Medicines Targeting Angiogenesis In Ischemic mentioning

confidence: 99%

Therapeutic Angiogenesis of Chinese Herbal Medicines in Ischemic Heart Disease: A Review

et al. 2018

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Ischemic heart disease (IHD) is one of the primary causes of death around the world. Therapeutic angiogenesis is a promising innovative approach for treating IHD, improving cardiac function by promoting blood perfusion to the ischemic myocardium. This treatment is especially important for targeting patients that are unable to undergo angioplasty or bypass surgery. Chinese herbal medicines have been used for more than 2,500 years and they play an important role alongside contemporary medicines in China. Growing evidence in animal models show Chinese herbal medicines can provide therapeutic effect on IHD by targeting angiogenesis. Identifying the mechanism in which Chinese herbal medicines can promote angiogenesis in IHD is a major topic in the field of traditional Chinese medicine, and has the potential for advancing therapeutic treatment. This review summarizes the progression of research and highlights potential pro-angiogenic mechanisms of Chinese herbal medicines in IHD. In addition, an outline of the limitations of Chinese herbal medicines and challenges they face will be presented.

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Compatibility Study of Danggui Buxue Tang on Chemical Ingredients, Angiogenesis and Endothelial Function

Cited by 14 publications

References 14 publications

<p>Encapsulated <em>n</em>-Butylidenephthalide Efficiently Crosses the Blood–Brain Barrier and Suppresses Growth of Glioblastoma</p>

<p>Encapsulated <em>n</em>-Butylidenephthalide Efficiently Crosses the Blood–Brain Barrier and Suppresses Growth of Glioblastoma</p>

Inhibition of Aortic Intimal Hyperplasia and Vascular Smooth Muscle Proliferation and Extracellular Matrix Protein Expressions by Astragalus–Angelica Combination

Therapeutic Angiogenesis of Chinese Herbal Medicines in Ischemic Heart Disease: A Review

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