Compatibility study between atorvastatin and excipients using DSC and FTIR

Silva, Edilamar Pereira da; Pereira, Maxciara Agda Vicente; Lima, Igor Prado de Barros; Lima, Naiana Gondim P. B.; Barbosa, Euzébio Guimarães; Aragão, Cícero Flávio Soares; Gomes, Ana Paula Barrêto

doi:10.1007/s10973-015-5077-z

Cited by 34 publications

(14 citation statements)

References 13 publications

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“…The instrument was calibrated using a standard material, i.e., indium. The calibration process involved the rising temperature experiment with the temperature range from -90 to 300°C at a heating rate 10-20°C min -1 and at a nitrogen flow rate 50 mL min -1 [17]. The average mass of samples is 7.0 mg.…”

Section: Methodsmentioning

confidence: 99%

Melting/freezing points of high concentrations of AlCl3 in a saturated chloroaluminate ionic liquid

Zhang

Groves

Counce

et al. 2015

J Therm Anal Calorim

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Melting/freezing points of AlCl 3 in saturated chloroaluminate ionic liquids [molar ratio 2:1 AlCl 3 : 1-ethyl-3-methyl imidazolium chloride (EMIC)] are measured by differential scanning calorimetry (DSC). A critical range of temperature data (50-130°C) for AlCl 3 dissolution and precipitation from saturated chloroaluminate ionic liquids is obtained. This range of temperature data is of significance to control phase transition of AlCl 3 in saturated chloroaluminate ionic liquids. By applying the chloroaluminate ionic liquids to electrolytes for energy storage usage, solid AlCl 3 can be partially dissolved and precipitated out during the charging/discharging cycle of energy storage equipment. Therefore, the energy density of the electrolytes is expected to be greatly improved.

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Section: Methodsmentioning

confidence: 99%

Melting/freezing points of high concentrations of AlCl3 in a saturated chloroaluminate ionic liquid

Zhang

Groves

Counce

et al. 2015

J Therm Anal Calorim

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“…Moderate correlations are between 0.5 and 0.80, indicating possible interactions. Values below 0.50 indicate low similarity between spectra, demonstrating chemical degradation [15,22,23].…”

Section: Fourier Transformed Infrared Spectroscopy (Ftir)mentioning

confidence: 99%

“…excipients. Therefore, it has been used as a supplementary technique to confirm the results obtained from the thermal analysis [15,22,23]. Figure 5 shows Pearson's correlation comparison analysis for every binary mixture that does not have reasonable deviations from the theoretical and experimental spectra.…”

Section: Compatibility Study Of the Binary Mixture By Ftirmentioning

confidence: 99%

“…Consequently, they identified important incompatibilities to many of the excipients analyzed. In the literature, there are many other examples of preformulation studies applying thermoanalytical techniques with strong evidences of interactions and incompatibilities [20][21][22][23].…”

Section: Introductionmentioning

confidence: 99%

“…Several reports are described in the literature to evaluate the interactions between API and excipients using thermal and non-thermal techniques, for example Fourier transformed infrared spectroscopy (FTIR), HPLC, LC-MS/TOF and LC/UV applying mathematical and statistical models to correlate and analyze the results obtained [21][22][23][24][25][26][27][28][29][30].…”

Section: Introductionmentioning

confidence: 99%

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Compatibility study between ferulic acid and excipients used in cosmetic formulations by TG/DTG, DSC and FTIR

Bezerra

Pereira

Ostrosky

et al. 2016

J Therm Anal Calorim

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Ferulic acid (4-hydroxy-3-methoxycinnamic acid) is a phytochemical constituent from the polyphenols group commonly found in whole grains, spinach, parsley, grapes and rhubarb. It has been widely applied in skin care formulations as photoprotective agent and delayer of cutaneous photoaging processes. This work aims to establish a protocol to the development of cosmetic formulations using thermoanalytical techniques (TG/DTG and DSC) and Pearson's correlation by FTIR data, in order to evaluate the compatibility between ferulic acid and excipients used in skin care formulations. The results obtained from the thermoanalytical techniques indicated compatibility between ferulic acid and the following excipients: passion fruit seed oil, Carbopol Ò Ultrez 30, EDTA, Crodabase CR2 Ò , Crodamol TM GTCC and Dow Corning Ò RM 2051. Nevertheless, the analysis also demonstrated the possibility of some interaction between ferulic acid and the following excipients: glyceryl stearate, Rapithix Ò A-60 and Optiphen Ò . To validate these results, it was demonstrated by Pearson's correlation that passion fruit seed oil, Carbopol Ò Ultrez 30, EDTA, Crodabase CR2 Ò , Crodamol TM GTCC, Dow Corning Ò RM 2051, glyceryl stearate and Rapithix Ò A-60 do not have any incompatibility that may compromise ferulic acid properties. Finally, it was also proved a meaningful incompatibility between ferulic acid and Optiphen Ò using Pearson's correlation. Thus, it is not recommended to use Optiphen Ò in the development of cosmetic formulations to carry ferulic acid.

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Effect of the rigid segment content on the properties of segmented polyurethanes conjugated with atorvastatin as chain extender

Zapata-Catzin

Bonilla-Hernández

Vargas-Coronado

et al. 2018

J Mater Sci: Mater Med

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Compatibility study between atorvastatin and excipients using DSC and FTIR

Cited by 34 publications

References 13 publications

Melting/freezing points of high concentrations of AlCl3 in a saturated chloroaluminate ionic liquid

Melting/freezing points of high concentrations of AlCl3 in a saturated chloroaluminate ionic liquid

Compatibility study between ferulic acid and excipients used in cosmetic formulations by TG/DTG, DSC and FTIR

Effect of the rigid segment content on the properties of segmented polyurethanes conjugated with atorvastatin as chain extender

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