Compatibility of various admixtures with secondary additives at Y-injection sites of intravenous administration sets

Physical compatibility of cisatracurium with selected drugs during simulated Y-site administration

“…4,5 To simulate a 1:1 ratio combination of drug and diluent through a Y-injection site, 2.5 mL of each test drug solution was mixed in triplicate with either 2.5 mL of 0.9% sodium chloride injection as a control or 2.5 mL of cisatracurium 1 mg/mL in a borosilicate test tube. a This method was outlined by Allen et al 6 and is consistent with well-designed compatibility studies. 7 A calibrated pipette was used to draw up each 2.5-mL solution to maintain accuracy with each testing.…”

Physical compatibility of telavancin hydrochloride with select i.v. drugs during simulated Y-site administration

“…3 This was simulated by mixing 5 mL of the telavancin 7.5 mg/mL with 5 mL of a secondary drug into a 15-mL, colorless, screw-cap, borosilicate glass culture tube. f This process was conducted in duplicate to yield four different test solutions for each secondary drug solution mixed with the telavancin solution.…”

Compatibility of ceftaroline fosamil for injection with selected drugs during simulated Y-site administration

“…fluid in an administration set with a secondary additive from a Y-injection site has been reported to occur in a 1:1 ratio. 6 Therefore, a 5-mL sample of ceftaroline fosamil solution (2.22 mg/mL) was combined at room temperature (23 °C) with a 5-mL sample of each of the 73 secondary drug solutions. Samples were tested in colorless 15-mL borosilicate glass screw-cap culture tubes with polypropylene caps, f as described by Trissel and Martinez.…”