Compatibility of ceftaroline fosamil for injection with selected drugs during simulated Y-site administration

Singh, Brahma N.; Dedhiya, Mahendra G.; DiNunzio, James; Chan, Pak Cheung; Kupiec, Thomas C.; Trissel, Lawrence A.; Laudano, Joseph B.

doi:10.2146/ajhp100606

Cited by 8 publications

(5 citation statements)

References 11 publications

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“…We also assessed the Trissel's™ 2 Clinical Pharmaceutics Database, a comprehensive database created by Lawrence A. Trissel that includes data for drug–drug and drug‐PN intravenous compatibility. We determined that there was sufficient evidence to support the compatibility recommendations issued in this article with the following drugs: cefepime, ceftazidime, cloxacillin, fosfomycin, meropenem, piperacillin/tazobactam and vancomycin 4,10–13 . However, we need to consider the studied antibiotic concentrations to understand this further and avoid errors.…”

Section: Drug Concentrationa Vehicle 3‐in‐1 2‐in‐1 Comments Referencesmentioning

confidence: 91%

“…We determined that there was sufficient evidence to support the compatibility recommendations issued in this article with the following drugs: cefepime, ceftazidime, cloxacillin, fosfomycin, meropenem, piperacillin/tazobactam and vancomycin. 4,[10][11][12][13] However, we need to consider the studied antibiotic concentrations to understand this further and avoid errors. Some drugs can have different compatibility or stability depending on the vehicle or the final concentration, such as meropenem or morphine.…”

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confidence: 99%

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Critical Commentary on the paper: Compatibility of prolonged infusion antibiotics during Y‐site administration with parenteral nutrition

Pourcq

Riera

2023

Nursing in Critical Care

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Section: Drug Concentrationa Vehicle 3‐in‐1 2‐in‐1 Comments Referencesmentioning

confidence: 91%

mentioning

confidence: 99%

Critical Commentary on the paper: Compatibility of prolonged infusion antibiotics during Y‐site administration with parenteral nutrition

Pourcq

Riera

2023

Nursing in Critical Care

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“…The analytical grade powder was dissolved with in deionized water to produce stock standard solutions, which are stable for ≥72 hours at 4°C. [ 14 ] The calibration curves were demonstrated by running the standard solutions at 6 different concentrations ranging from 50 to 1000 μg/mL for MSS and 10 to 100 μg/mL for GH.…”

Section: Methodsmentioning

confidence: 99%

Compatibility and stability of methylprednisolone sodium succinate and granisetron hydrochloride in 0.9% sodium chloride solution

et al. 2022

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A combination of methylprednisolone sodium succinate (MSS) and granisetron hydrochloride (GH) is generally devoted to treating the chemotherapy-induced nausea and vomiting. To date, none of these novel mixtures have been commercially available. The present study was aimed at investigating physical and chemical compatibility and stability of a combination of MSS with GH in 0.9% sodium chloride injection for 72 hours at 4°C and 25°C. A mixture of MSS (0.4–0.8 mg/mL) with GH (0.03 mg/mL) was prepared and stored in both polyvinyl chloride bags and glass bottles using 0.9% sodium chloride injection as a diluent. The study was performed using a validated and stability-indicating high-performance liquid chromatography method. The physical compatibility was assessed by a spectrometer. Furthermore, the pH measurement of each sample was measured electronically. All test solutions stored at 4°C or 25°C had a no >2% loss of the initial concentration throughout the 72-hour study period. All solutions remained clear and colorless throughout the study and were without precipitation or turbidity in any of the batches. The drug mixtures of MSS (0.4–0.8 mg/mL) and GH (0.03 mg/mL) in 0.9% sodium chloride injections were physically and chemically stable for at least 72 hours when stored at 4°C or 25°C in polyvinyl chloride bags or glass bottles.

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“…48 Moreover, ceftaroline, a novel broad-spectrum cephalosporin with bactericidal activity against drug-resistant gram-positive organisms, was found to be incompatible with dobutamine depending on the specific infusion solution used to prepare the mixtures. 49…”

Section: Beta-lactam Antibioticsmentioning

confidence: 99%

Compatibility of prolonged infusion antibiotics during Y‐site administration

Núñez-Núñez

Murillo-Izquierdo

Moya-Martin

et al. 2022

Nursing in Critical Care

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Background: Antimicrobial resistance is a threat to global public health. The use of prolonged infusions in the hospital setting for certain antimicrobials is widely increasing in order to improve their efficacy and safety, including resistance development.Due to limited vascular access, it is important to clarify whether they can be infused through the same line with other drugs during Y-site administration.Aim: The aim of this review is to update and summarize the evidence on Y-site compatibility of antibacterial agents administered as prolonged infusions in intensive care units (ICUs).Study Design: A literature review of PubMed, EMBASE and Trissel's Handbook on Injectable Drugs databases was conducted on the compatibility of selected antimicrobials administered simultaneously at a Y-site connection with parenteral nutrition and other widely used drugs in ICUs. All articles published up to October 30, 2021, in English or Spanish were included, regardless of the type of publication (original articles, case reports, letters, etc.). Eligible antimicrobials were those that can be administered as prolonged infusions: ceftazidime, cefepime, piperacillin/tazobactam, meropenem, ceftolozane/tazobactam, ceftaroline, cloxacillin, ceftobiprole, vancomycin and fosfomycin.Results: A total of 1302 drug-to-drug potential combinations were explored, 196 (15.05%) were found to be incompatible, and in 541 (41.55%), data were not available. The results were presented in a simple 2-dimensional consultation chart as a quick reference for health care professionals.Conclusions: This review provides useful and reliable information on the compatibility of antimicrobials administered as Y-site infusion with other drugs commonly used in the critical setting. This review contributes to patient safety in nursing practice.Relevance to Clinical Practice: To our knowledge, this is the first review on Y-site compatibility of antimicrobials used as prolonged infusions with other commonly used drugs, including anti-emetics, analgesics and anti-epileptic and parenteral nutrition. The results of the current review need to be addressed to promote the knowledge sharing between health professionals and improve the quality and safety of

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Compatibility of ceftaroline fosamil for injection with selected drugs during simulated Y-site administration

Cited by 8 publications

References 11 publications

Critical Commentary on the paper: Compatibility of prolonged infusion antibiotics during Y‐site administration with parenteral nutrition

Critical Commentary on the paper: Compatibility of prolonged infusion antibiotics during Y‐site administration with parenteral nutrition

Compatibility and stability of methylprednisolone sodium succinate and granisetron hydrochloride in 0.9% sodium chloride solution

Compatibility of prolonged infusion antibiotics during Y‐site administration

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