Compassionate use of the PASCAL transcatheter mitral valve repair system for patients with severe mitral regurgitation: a multicentre, prospective, observational, first-in-man study

Praz, Fabien; Spargias, Konstantinos; Chrissoheris, Michael; Büllesfeld, Lutz; Nickenig, Georg; Deuschl, Florian; Schueler, Robert; Fam, Neil; Moss, Robert; Makar, Moody; Boone, Robert H.; Edwards, Jeremy; Moschovitis, Aris; Kar, Saibal; Webb, John G.; Schäfer, Ulrich; Feldman, Ted; Windecker, Stephan

doi:10.1016/s0140-6736(17)31600-8

Cited by 207 publications

(120 citation statements)

References 18 publications

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“…The first-in-human study enrolled 23 patients with moderate-to-severe mitral regurgitation using the PASCAL system showed the feasibility with a high rate of technical success and reduction of mitral regurgitation severity. 40 The first 12 cases of using PASCAL to treat severe TR were reported recently. 41,42…”

Section: Pascalmentioning

confidence: 99%

Transcatheter Edge-to-edge Repair of Severe Tricuspid Regurgitation

Lin

Miura

Züber

et al. 2019

US Cardiology Review

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Despite the increasing knowledge of the long-term adverse consequence of severe tricuspid regurgitation (TR), most patients with moderateto-severe TR are still treated conservatively because of the high risk of surgery. Percutaneous procedures have emerged as an attractive alternative treatment. Transcatheter edge-to-edge repair is a validated technique to treat mitral regurgitation. In recent years, the same concept has been applied to patients with TR and prohibitive operative risk. Early trials have shown feasibility and safety. More clinical experiences and long-term results are still being gathered. In this article, we provide an overview of transcatheter edge-to-edge repair and look at the current evidence and clinical results regarding procedure.

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Section: Pascalmentioning

confidence: 99%

Transcatheter Edge-to-edge Repair of Severe Tricuspid Regurgitation

Lin

Miura

Züber

et al. 2019

US Cardiology Review

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“…Initial results in human trials have demonstrated percutaneous mitral repair with the Edwards PASCAL™ system appears safe and feasible. A prospective multicentre study has been intitiated that will assess a composite end‐point of all‐cause mortality or recurrent heart failure hospitalisations and has an estimated primary completion date in July 2018 …”

Section: Percutaneous Valve Intervention For Mitral Regurgitationmentioning

confidence: 99%

Transcatheter mitral valve intervention: an emerging treatment for mitral regurgitation

Markham

Kyranis

Aroney

et al. 2018

Internal Medicine Journal

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Mitral regurgitation (MR) is a valvular heart disease associated with significant morbidity and mortality. Transcatheter mitral valve intervention (TMVI) repairs or replaces the mitral valve through small arterial and venous entry sites and so avoids risks associated with open heart surgery. Transcatheter devices targeting components of the mitral apparatus are being developed to repair or replace it. Numerous challenges remain including developing more adaptable devices and correction of multiple components of the mitral annulus to attain durable results. The mitral valve apparatus is a complex structure and understanding of the mechanisms of MR is essential in the development of TMVI. There will likely be a complementary role between surgery and TMVI in the near future.

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“…The cardiologist's way to do the Alfieri stitch: transcatheter mitral valve edge-to-edge repair revisited transcatheter mitral valve repair system, which has been investigated in a multicenter, prospective, observational, first-in-man study (21). Twenty-three patients suffering from symptomatic, severe functional, degenerative or combined functional and degenerative mitral regurgitation were included.…”

Section: Editorialmentioning

confidence: 99%

“…The guide sheath and the catheter can be controlled using rotational knobs on the handles. The implant consists of a 10-mm spacer, which acts as a filler in the regurgitation orifice (21), and that is attached to two paddles with about 25 mm width in grasping position and clasps of 10 mm lengths. This spacer in combination with the-compared to the MitraClipwider and longer paddles, and the ability to independently grasp the anterior and posterior leaflet, might allow to treat patients with functional and different types of degenerative mitral regurgitation.…”

Section: Editorialmentioning

confidence: 99%

The cardiologist’s way to do the Alfieri stitch: transcatheter mitral valve edge-to-edge repair revisited

Rassaf

2017

J. Thorac. Dis.

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Compassionate use of the PASCAL transcatheter mitral valve repair system for patients with severe mitral regurgitation: a multicentre, prospective, observational, first-in-man study

Cited by 207 publications

References 18 publications

Transcatheter Edge-to-edge Repair of Severe Tricuspid Regurgitation

Transcatheter Edge-to-edge Repair of Severe Tricuspid Regurgitation

Transcatheter mitral valve intervention: an emerging treatment for mitral regurgitation

The cardiologist’s way to do the Alfieri stitch: transcatheter mitral valve edge-to-edge repair revisited

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