Compartmental volumetry of the superior temporal gyrus reveals sex differences in schizophrenia—a post-mortem study

Vogeley, Kai; Hobson, T.; Schneider‐Axmann, Thomas; Honer, William G.; Bogerts, Bernhard; Falkai, Peter

doi:10.1016/s0920-9964(98)00019-x

Cited by 21 publications

(9 citation statements)

References 14 publications

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“…The observation of reduced mean pyramidal cell somal volume in BA42, regardless of whether resulting from smaller or fewer cells, is consistent with both MRI and postmortem findings of reduced gray matter volume of the STG of subjects with schizophrenia (Highley et al, 1999;Falkai et al, 1995;Vogeley et al, 1998;McCarley et al, 1999). However, the smaller mean pyramidal cell size observed in deep layer 3 of BA42 is unlikely to represent the only source contributing to the observation of reduced gray matter volume in this region.…”

Section: Discussionsupporting

confidence: 84%

Reduced Pyramidal Cell Somal Volume in Auditory Association Cortex of Subjects with Schizophrenia

Sweet

Pierri

Auh

et al. 2002

Neuropsychopharmacol

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Subjects with schizophrenia have decreased gray matter volume of auditory association cortex in structural imaging studies, and exhibit deficits in auditory sensory memory processes subserved by this region. In dorsal prefrontal cortex (dPFC), similar in vivo observations of reduced regional volume and working memory deficits in subjects with schizophrenia have been related to reduced somal volume of deep layer 3 pyramidal cells. We hypothesized that deep layer 3 pyramidal cell somal volume would also be reduced in auditory association cortex (BA42) in schizophrenia. We used the nucleator to estimate the somal volume of pyramidal neurons in deep layer 3 of BA42 in 18 subjects with schizophrenia, each of whom was matched to one normal comparison subject for gender, age, and postmortem interval. For all subject pairs, somal volume of pyramidal neurons in deep layer 3 of dPFC (BA9) had previously been determined. In BA42, somal volume was reduced by 13.1% in schizophrenic subjects (p ¼ 0.03). Reductions in somal volume were not associated with the history of antipsychotic use, alcohol dependence, schizoaffective disorder, or death by suicide. The percent change in somal volume within-subject pairs was highly correlated between BA42 and BA9 (r ¼ 0.67, p ¼ 0.002). Deep layer 3 pyramidal cell somal volume is reduced in BA42 of subjects with schizophrenia. This reduction may contribute to impairment in auditory function. The correlated reductions of somal volume in BA42 and BA9 suggest that a common factor may affect deep layer 3 pyramidal cells in both regions.

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Section: Discussionsupporting

confidence: 84%

Reduced Pyramidal Cell Somal Volume in Auditory Association Cortex of Subjects with Schizophrenia

Sweet

Pierri

Auh

et al. 2002

Neuropsychopharmacol

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“…Consistent with structural MRI findings, post-mortem studies have found reductions in STG grey matter volume in individuals with schizophrenia 108–112 . Early studies primarily utilized morphometric measurements to assess cortical thickness and/or neural volume, whereas more recent approaches have used antibodies directed against cellular proteins to differentiate neuronal subcomponents, projection pathways and cell types in assessments of structural integrity.…”

Section: Structural and Histological Findingssupporting

confidence: 65%

Auditory dysfunction in schizophrenia: integrating clinical and basic features

2015

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Schizophrenia is a complex neuropsychiatric disorder that is associated with persistent psychosocial disability in affected individuals. Although studies of schizophrenia have traditionally focused on deficits in higher-order processes such as working memory and executive function, there is an increasing realization that, in this disorder, deficits can be found throughout the cortex and are manifest even at the level of early sensory processing. These deficits are highly amenable to translational investigation and represent potential novel targets for clinical intervention. Deficits, moreover, have been linked to specific structural abnormalities in post-mortem auditory cortex tissue from individuals with schizophrenia, providing unique insights into underlying pathophysiological mechanisms.

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“…Gray matter deficits alone within both the IFG and STG have been described in previous imaging studies involving first episode (Hirayasu et al, 1998; Kubicki et al, 2002) and chronic (Yamasue et al, 2004) subjects, as well as in post mortem studies (Vogeley et al, 1998) of patients with schizophrenia (see also review in McCarley et al, 1999 and Shenton et al, 2001). White matter abnormalities involving the Arcuate Fasciculus, which is still believed to be the major language pathway, have also been reported in DTI studies involving patients with schizophrenia (Douaud et al, 2007; Hubl et al, 2004; Kubicki et al, 2005).…”

Section: Discussionmentioning

confidence: 70%

Stochastic tractography study of Inferior Frontal Gyrus anatomical connectivity in schizophrenia

et al. 2011

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Background-Abnormalities within language-related anatomical structures have been associated with clinical symptoms and with language and memory deficits in schizophrenia. Recent studies suggest disruptions in functional connectivity within the Inferior Frontal Gyrus (IFG) network in schizophrenia. However, due to technical challenges, anatomical connectivity abnormalities within this network and their involvement in clinical and cognitive deficits have not been studied.Material and Methods-Diffusion and anatomical scans were obtained from 23 chronic schizophrenia patients and 23 matched controls. The IFG was automatically segmented, and its white matter connections extracted and measured with newly-developed stochastic tractography tools. Correlations between anatomical structures and measures of semantic processing were also performed. Results-WhiteMatter connections between the IFG and posterior brain regions followed two distinct pathways: dorsal and ventral. Both demonstrated left lateralization, but ventral pathway abnormalities were only found in schizophrenia. IFG volumes also showed left lateralization and Corresponding Author: Marek Kubicki, MD, PhD; Psychiatry Neuroimaging Laboratory; 1249 Boylston Street, Boston, MA 02215; Tel: (617) 525-6234 Fax: (617) 525-6150, kubicki@bwh.harvard.edu. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. NIH Public Access Author ManuscriptNeuroimage. Author manuscript; available in PMC 2012 April 15. NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript abnormalities in schizophrenia. Further, despite similar laterality and abnormality patterns, IFG volumes and white matter connectivity were not correlated with each other in either group. Interestingly, measures of semantic processing correlated with white matter connectivity in schizophrenia and with gray matter volumes in controls. Finally, hallucinations were best predicted by both gray matter and white matter measures together.Conclusions-Our results suggest abnormalities within the ventral IFG network in schizophrenia, with white matter abnormalities better predicting semantic deficits. The lack of a statistical relationship between coexisting gray and white matter deficits might suggest their different origin and the necessity for a multimodal approach in future schizophrenia studies.

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Compartmental volumetry of the superior temporal gyrus reveals sex differences in schizophrenia—a post-mortem study

Cited by 21 publications

References 14 publications

Reduced Pyramidal Cell Somal Volume in Auditory Association Cortex of Subjects with Schizophrenia

Reduced Pyramidal Cell Somal Volume in Auditory Association Cortex of Subjects with Schizophrenia

Auditory dysfunction in schizophrenia: integrating clinical and basic features

Stochastic tractography study of Inferior Frontal Gyrus anatomical connectivity in schizophrenia

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