Compartmental tongue surgery: Long term oncologic results in the treatment of tongue cancer

Calabrese, Luca; Bruschini, Roberto; Giugliano, Gioacchino; Ostuni, Angelo; Maffini, Fausto; Massaro, Maria; Santoro, Luigi; Navach, Valeria; Preda, Lorenzo; Alterio, Daniela; Ansarin, Mohssen; Chiesa, Fausto

doi:10.1016/j.oraloncology.2010.12.006

Cited by 79 publications

(73 citation statements)

References 39 publications

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“…4 At the beginning of this century, the more frequent approach was a wide resection with larger free macroscopic margins (1.5-2 cm). 18,19 It follows that surgical treatment of tongue cancers should be planned according to these clinical, pathological, and imaging findings. [15][16][17] From a functional point of view, we should also underline that tongue resection often partially cut the muscles in such way that they lose their function.…”

Section: Introductionmentioning

confidence: 99%

“…5 Today we can better plan how to perform tongue tumor removal as a result of improved knowledge of the manner of superficial and deeper local tumoral spread along the muscles, the nerves, and the vessels, 6-12 improved imaging techniques, 13,14 which allow surgeons to evaluate the involvement of each tongue muscle, and the new eighth edition American Joint Committee on Cancer (AJCC) TNM staging system. [19][20][21][22][23] Accurate preoperative evaluation, a precise analysis of the MRI or CT scan images, and staging using eighth edition of AJCC/Union Internationale Contre le Cancer (UICC)/ TNM classification is therefore essential. 18,19 It follows that surgical treatment of tongue cancers should be planned according to these clinical, pathological, and imaging findings.…”

Section: Introductionmentioning

confidence: 99%

“…[15][16][17] From a functional point of view, we should also underline that tongue resection often partially cut the muscles in such way that they lose their function. 18,19 It follows that surgical treatment of tongue cancers should be planned according to these clinical, pathological, and imaging findings. Early stages can usually be approached via the transoral route as the affected tissue grows and develops on the tongue mucosa or within the intrinsic muscles, and therefore, can be radically excised without necessitating extra-oral access.…”

Section: Introductionmentioning

confidence: 99%

“…When, however, the tumor affects one or more extrinsic muscles which have extralingual insertions, it is necessary to perform an en bloc combined transoral and lateral cervical approach to remove the muscles in toto from their insertions. [19][20][21][22][23] Accurate preoperative evaluation, a precise analysis of the MRI or CT scan images, and staging using eighth edition of AJCC/Union Internationale Contre le Cancer (UICC)/ TNM classification is therefore essential.…”

Section: Introductionmentioning

confidence: 99%

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Classification of GLOSSECTOMIES: Proposal for tongue cancer resections

et al. 2019

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Background Surgery of tongue tumors includes different procedures ranging from mucosal resection to complex combined resection. Numerous terms have been used to describe such procedures, but there is no consensus between the terminology and the extent of resection. Methods and Results We searched the medical literature and found a lack of published information. We undertook to describe a new classification of surgical procedures for tongue tumor resection. We based it upon the surgical anatomy of the tongue and the spread of the cancer. We posited that there were five major types of glossectomy embracing all the methods of tongue cancer resection. This classification was reviewed and endorsed by an international team of experts. Conclusion We propose a more precise classification than that currently in practice, thereby bringing clarity and consistency to the terminology, facilitating shared communication between surgeons, comparison between published research, and ultimately improving surgical practice and patient care.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Classification of GLOSSECTOMIES: Proposal for tongue cancer resections

et al. 2019

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“…The numbers of elderly patients with tongue cancer is expected to increase in the future. Nowadays, surgery is the therapeutic mainstay for early-stage tongue cancer, but it is often part of a multi-modal approach to treat advanced disease (Calabrese et al, 2011). However, many elderly patients may not be considered as candidates for aggressive multimodal treatments due to other ageing-associated comorbidities, general debility, and concerns regarding low tolerance to treatment and resulting toxicity (Siddiqui & Gwede, 2012; Zabrodsky et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Mortality in tongue cancer patients treated by curative surgery: a retrospective cohort study from CGRD

Tsai

Lai

Lee

et al. 2016

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BackgroundOur study aimed to compare the outcomes of surgical treatment of tongue cancer patients in three different age groups.MethodsFrom 2004 to 2013, we retrospectively analyzed the clinical data of 1,712 patients who were treated in the four institutions constituting the Chang Gung Memorial Hospitals (CGMH). We divided and studied the patients in three age groups: Group 1, younger (<65 years); Group 2, young old (65 to <75); and Group 3, older old patients (≥75 years).ResultsMultivariate analyses determined the unfavorable, independent prognostic factors of overall survival to be male sex, older age, advanced stage, advanced T, N classifications, and surgery plus chemotherapy. No significant differences were found in adjusted hazard ratios (HR) of death in early-stage disease (stage I–II) among Group 1 (HR 1.0), Group 2 (HR 1.43, 95% confidence interval (CI) [0.87–2.34], p = 0.158), and Group 3 (HR 1.22, 95% CI [0.49–3.03], p = 0.664) patients. However, amongst advanced-stage patients (stage (III–IV)), Group 3 (HR 2.53, 95% CI [1.46–4.38], p = 0.001) showed significantly worse survival than the other two groups after other variables were adjusted for. Fourteen out of 21 older old, advanced-staged patients finally died, and most of the mortalities were non-cancerogenic (9/14, 64.3%), and mostly occurred within one year (12/14, 85%) after cancer diagnosis. These non-cancer cause of death included underlying diseases in combination with infection, pneumonia, poor nutrition status, and trauma.ConclusionsOur study showed that advanced T classification (T3–4), positive nodal metastasis (N1–3) and poorly differentiated tumor predicted poor survival for all patients. Outcome of early-stage patients (stage I–II) among three age groups were not significantly different. However, for advanced-stage patients (stage III–IV), the older old patients (≥75) had significantly worse survival than the other two patient groups. Therefore, for early-stage patients, age should not deny them to receive optimal treatments. However, older old patients (≥75) with advanced cancer should be comprehensively assessed by geriatric tools before surgical treatment and combined with intensive postoperative care to improve outcome, especially the unfavorable non-cancerogenic mortalities within one year after cancer diagnosis.

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Compartmental surgery for oral tongue and floor of the mouth cancer: Oncologic outcomes

et al. 2018

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Background: Oral tongue/floor of mouth squamous cell carcinoma (OTFMSCC) with a depth of invasion (DOI) > 10 mm involves extrinsic muscles and lingual neurovascular/lymphatic bundles. "Compartmental" hemiglossopelvectomy (CHGP) was developed to improve loco-regional control by "en bloc" removal of tumor and its pathways of spread. Methods: We conducted a retrospective observational study on 45 CHGPs performed at a single institution for OTFMSCC with a DOI > 10 mm at CT/MR. Group A (n = 35) included naïve patients, and group B (n = 10) recurrent cancers. We evaluated 2-year overall survival (OS), disease-free survival (DFS), local control (LC), and loco-regional control (LRC). Results: Two-year OS, DFS, LC, and LRC were 80%, 91%, 100%, and 94% for group A, and 27%, 26%, 67%, and 36% for group B, respectively. Salvage surgery and positive margins were significantly associated with worse prognosis. Conclusion: CHGP is a reliable oncologic approach in primary surgery for advanced OTFMSCC. In recurrent cancers, survival remains poor. K E Y W O R D S compartmental surgery, floor of mouth, hemiglossopelvectomy, oral tongue, squamous cell carcinoma

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Compartmental tongue surgery: Long term oncologic results in the treatment of tongue cancer

Cited by 79 publications

References 39 publications

Classification of GLOSSECTOMIES: Proposal for tongue cancer resections

Classification of GLOSSECTOMIES: Proposal for tongue cancer resections

Mortality in tongue cancer patients treated by curative surgery: a retrospective cohort study from CGRD

Compartmental surgery for oral tongue and floor of the mouth cancer: Oncologic outcomes

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