Comparitive study on protective gloves for handling cytotoxic medicines: a model study with carmustine

Dinter-Heidorn, Heike; Carstens, Gerhard

doi:10.1007/bf01962535

Cited by 9 publications

(6 citation statements)

References 1 publication

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“…Data obtained is consistent with that reported in previous studies (1). Data obtained is consistent with that reported in previous studies (1).…”

Section: Resultssupporting

confidence: 93%

“…International quality standards are stated being more or less insufficient as far as special requirements on protective gloves for handling eytotoxic medicines are concerned [1], With the intention to find data more meaningful several investigators examined protective gloves with regard to the permeability to cytotoxin medicines [2,3,4]. The permeability of three protective gloves for the preparation of eytotoxic medicines available on the market, one protective glove intending to enter the market, and two nol specialised protective gloves which are used together dudng the preparation of cytotoxic medicines was studied.…”

Section: Cytomegalovirusmentioning

confidence: 99%

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Abstracts of papers and posters safe handling of medicines

Meyer¹,

Tromp

Kleijn³

et al. 1993

Pharm World Sci

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“…Data obtained is consistent with that reported in previous studies (1). Data obtained is consistent with that reported in previous studies (1).…”

Section: Resultssupporting

confidence: 93%

Section: Cytomegalovirusmentioning

confidence: 99%

Abstracts of papers and posters safe handling of medicines

Meyer¹,

Tromp

Kleijn³

et al. 1993

Pharm World Sci

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“…Moreover, the number of chemicals tested varied considerably from one study to the next, ranging from a single chemical to 15 chemicals, but many studies used fewer than 7 chemicals. 9,10,[21][22][23][24][25][26]29 This makes it harder to compare the relative behaviour of different chemicals under identical experimental conditions with the same gloves. In this study we tested 27 chemicals, and only 3 had permeation rates above the US standard ASTM D-6978-05 (carmustine, busulfan and thiotepa) with some gloves.…”

Section: Discussionmentioning

confidence: 99%

“…The chemical most often found to have high permeation rates was carmustine. 8,9,14,15,19,25,[29][30][31] As far as we know, this is the first time that busulfan has been tested in this type of study, and therefore no prior data were available. Finally, thiotepa has already been identified as a compound that permeates gloves in several studies.…”

Section: Discussionmentioning

confidence: 99%

Permeation measurement of 27 chemotherapy drugs after simulated dynamic testing on 15 surgical and examination gloves: A knowledge update

Nalin

Hug

Boeckmans³

et al. 2020

J Oncol Pharm Pract

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Purpose Exposure to anticancer drugs is one of the known risks for people working in specialist oncology units. Wearing gloves is a vital form of personal protection. The aim of this study was to assess, in close to real use dynamic conditions, the permeability of 15 surgical and examination gloves made from different materials when exposed to 27 anticancer drugs included in the list from international Guides and Recommendations. Methods Gloves were tested by using controlled dynamic conditions replicating flexion and extension movements that mimic typical clinical applications. Tests were performed at 37°C or at 43°C for 30 min and anticancer drugs were tested at the highest concentration used in clinical practice. To determine the permeation rate, the quantification of anticancer drugs was performed with selective and sensitive analytical methods such as inductively coupled plasma-mass spectroscopy and liquid chromatography-mass spectrometry. Results All the gloves met the EN 16523-1 European standard (1000 ng/(min.cm2)). The penetration rate of busulfan, carmustine and thiotepa exceeded the ASTM D-6978-05 American standard (10 ng/(min.cm2)) with several surgical and/or examination gloves. This standard was met in all of cases when double gloving was used. Breakage of several nitrile gloves was observed in relation with the excipient used by drugs suppliers. Conclusions Permeation is a complex multifactorial phenomenon. However, we have suggested that the thickness of the glove and three physicochemical parameters (molecular weight, topological polar surface area and hydrogen bond donor) of the drug were the main parameters affecting permeation.

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“…Methyl methacrylate used in orthopaedic surgery is the best known chemical against which rubber surgical gloves fail to offer protection (Pegum and Medhurst, 1971;Waegemaekers et al, 1983;Darre et al, 1987;Jensen et al, 1991). It has also been shown that examination gloves do not provide adequate protection against many cytotoxic drugs, and thus surgical gloves have been examined to identify which of these gloves acts as an adequate barrier to these agents Laidlaw et al, 1984;Slevin et al, 1984;Colligan and Horstman, 1990;Dinter-Heidorn and Carstens, 1992;Connor, 1995Connor, , 1999Klein et al, 1999;Singleton and Connor, 1999). A study by Connor and Xiang showed that a 5 min contact with 70% isopropyl alcohol does not increase the permeation of cytotoxic drugs through NR or nitrile rubber material.…”

Section: Introductionmentioning

confidence: 99%

The Permeability of Surgical Gloves to Seven Chemicals Commonly Used in Hospitals

Mäkelä

Vainiotalo

Peltonen

2003

The Annals of Occupational Hygiene

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Disinfectants may cause adverse effects directly on the skin or systemically by permeating through the skin. In this study breakthrough times were measured for surgical gloves with chemicals which are commonly used in healthcare. Classical methods of analytical chemistry were tailored for the permeation tests, which were carried out according to the European standard EN 374 and the American standard ASTM F739. An exception to the EN 374 standard was made by using a 4 h testing time instead of 8 h. The gloves did not exhibit permeation of potassium hydroxide (45%), sodium hypochlorite (13%) or hydrogen peroxide (30%). Furthermore, neither glutaraldehyde (2%) nor chlorhexidine digluconate (4%) in the commercial disinfectant solutions studied exhibited permeation. Slight permeation of peracetic acid (0.35%) and acetic acid (4%) from a disinfectant agent was observed through single layered natural rubber materials. Clear evidence of formaldehyde permeation was detected through single layered natural rubber gloves, where the ASTM breakthrough times were 17-67 min, but the permeation rates were not high enough for breakthrough to have occurred according to the EN standard. The gloves in this study which offered most protection from chemical permeation were the chloroprene gloves and the thick double layered natural rubber gloves.

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Comparitive study on protective gloves for handling cytotoxic medicines: a model study with carmustine

Cited by 9 publications

References 1 publication

Abstracts of papers and posters safe handling of medicines

Abstracts of papers and posters safe handling of medicines

Permeation measurement of 27 chemotherapy drugs after simulated dynamic testing on 15 surgical and examination gloves: A knowledge update

The Permeability of Surgical Gloves to Seven Chemicals Commonly Used in Hospitals

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