a b s t r a c tConcurrent tropospheric O 3 and CO vertical profiles from the Tropospheric Emission Spectrometer (TES) during the MILAGRO/INTEX-B aircraft campaigns over the Mexico City Metropolitan Area (MCMA) and its surrounding regions were used to examine Mexico City pollution outflow on a regional scale. The pollution outflow from the MCMA occurred predominantly at 600-800 hPa as evident in O 3 , CO, and NO x enhancements in the in situ aircraft observations. TES O 3 and CO are sensitive to the MCMA pollution outflow due to their relatively high sensitivities at 600-800 hPa. We examined O 3 , CO, and their correlation at 600-800 hPa from TES retrievals, aircraft measurements, and GEOS-Chem model results. TES captures much of the spatial and day-to-day variability of O 3 seen in the in situ data. TES CO, however, shows much less spatial and day-to-day variability compared with the in situ observations. The DO 3 /DCO slope is significantly higher in the TES data (0.43) than the in situ data (0.28) due partly to the lack of variability in TES CO. Extraordinarily high DO 3 /DCO slope (0.81) from TES observations at 618 hPa over the Eastern U.S. was previously reported