Comparisons of Serum Total IgE, IgG, and IgG1 Levels in Patients with and without Echinococcosis-Induced Anaphylactic Shock

Abstract

Abstract. We investigated serum total immunoglobulin E (IgE), IgG, and IgG1 levels in patients with and without echinococcosis-induced anaphylactic shock. This was a case-control study of 11 patients with echinococcosis-induced anaphylactic shock and 22 echinococcosis patients with cyst rupture but without anaphylactic shock. Blood was collected before surgery (T0), at the time of cyst rupture (T1), and shock (Tx), 1 h (T2), 1 day (T3), and 1 week (T4) after cyst rupture. Serum IgE, IgG, and IgG1 were determined by enzyme-linked immunosorbent assay. Serum IgE, IgG, and IgG1 levels were significantly higher in patients who developed anaphylactic shock at all time points. Increased presurgical IgG and IgG1 levels were identified to be a significant risk factors for developing anaphylactic shock. The results showed that a serum IgG concentration of 312.25 μg/mL could be used as a cut-off point to predict whether an echinococcosis patient would develop anaphylactic shock.

Recurrent Anaphylaxis: An Unruptured Splenic Hydatid Cyst as an Unusual Cause

“…The relationship between IgE levels and a hydatid cyst is thought to be more pronounced in patients that exhibit complications of anaphylaxis (14). Guisantes et al (15) reported that the IgE levels decreased following surgery in patients with a hydatid cyst.…”

Splenic epithelial cyst mistaken with Hydatid cyst: A case report

“…Accordingly, the association of elevated IgE level made the diagnosis more difficult. Although elevated IgE is not specific for hydatid disease, but is present in a large subset of affected individuals [ 14 ].…”

Factors Associated with Echinococcosis-Induced Perioperative Anaphylactic Shock

“…IgG is involved in anaphylactic shock or even death induced by antigens of parasites alongside IgE [ 14 , 21 ]. IgG accounts for about 75–80% of all immunoglobulins in the serum, and consists of 4 subtypes, IgG1, IgG2, IgG3, and IgG4 [ 22 ].…”

“…The diagnosis of echinococcosis is relatively straightforward using various imaging methods [ 13 ], but it may be difficult to predict which patients will develop anaphylaxis [ 4 , 13 , 14 ]. In the present study, we retrospectively analyzed the clinical and immunological data of patients with echinococcosis who developed anaphylactic shock in the perioperative period to identify the associated factors and to provide some evidence for prevention and treatment of this complication.…”