Comparisons of GnRH antagonist versus GnRH agonist protocol in poor ovarian responders undergoing IVF

Pu, Danhua; Wu, Jie; Liu, Jiayin

doi:10.1093/humrep/der240

Cited by 108 publications

(73 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…GnRH-ant has several advantages over the GnRH agonist (GnRH-a) such as a dramatic reduction in the duration of treatment and the amount of gonadotropin used for stimulation in comparison with agonist protocol [13,14]. Other potential benefits include the lower risk of ovarian hyperstimulation syndrome [15].…”

Section: Introductionmentioning

confidence: 99%

A comparative study on oxidative and antioxidative markers of serum and follicular fluid in GnRH agonist and antagonist cycles

Çelik

Kumbak

et al. 2012

J Assist Reprod Genet

View full text Add to dashboard Cite

Objective To determine whether concentrations of oxidative stress markers of follicular fluid and serum are different in GnRH agonist protocol from GnRH antagonist protocol. Material and method This was a cross-sectional study. Eighty-four women undergoing controlled ovarian stimulation with either GnRH agonist (n039) or GnRH antagonist protocols (n045) for IVF/ICSI treatment were assigned by a physician. Blood was obtained at the time of oocyte retrieval, and follicular fluid (FF) from the mature follicles of each ovary was centrifuged and frozen until analysis. Malondialdehyde (MDA), nitric oxide (NO), protein carbonyl (PC), hydroxyl proline (OH-P), sodium oxide dismutase (SOD), reduced glutathione (GSH), glutathione peroxidase (GSH-Px), adenosine deaminase (ADA) and xanthine oxidase (XO) were assessed in the serum and follicular fluid of each participants. ResultsThe mean serum concentrations of GSH-Px, GSH and MDA were lower in the GnRH antagonist group compared to GnRH agonist group, but mean serum SOD was higher in the GnRH antagonist group. The mean follicular SOD, ADA and NO were higher in GnRH antagonist group than GnRH agonist group. The IVF/ICSI outcomes were similar in both groups. Conclusion(s) GnRH antagonist protocol is associated with increased oxidative stress. The relation of GnRH analogues with oxidative stress and its implication in follicular growth needs to be addressed in further studies.

show abstract

Section: Introductionmentioning

confidence: 99%

A comparative study on oxidative and antioxidative markers of serum and follicular fluid in GnRH agonist and antagonist cycles

Çelik

Kumbak

et al. 2012

J Assist Reprod Genet

View full text Add to dashboard Cite

show abstract

“…The decision for using this protocol was because different authors proposed the GnRH agonist long protocol as the most useful in expected normal responders [34,36,41,42], which represent the great majority of our sample. As regards the management of expected poor responders, there are very few in this paper, even though there is a trend toward the use of GnRH antagonists [34,41,42]; the results of a recent paper [43] and those of two meta-analyses [44,45] do not indicate the superiority of one protocol of pituitary suppression over another. Moreover, in clinical practice, despite the growing use of the GnRH antagonist, the long standard protocol is still applied in a very high percentage of cycles.…”

Section: Discussionmentioning

confidence: 86%

The carriers of the A/G-G/G allelic combination of the c.2039 A>G and c.-29 G>A FSH receptor polymorphisms retrieve the highest number of oocytes in IVF/ICSI cycles

Allegra

Marino

Raimondo

et al. 2016

J Assist Reprod Genet

View full text Add to dashboard Cite

Purpose The objective of this study was the elucidation of the possible role of the single-nucleotide polymorphisms (SNP) at position -29 and 2039 of the FSH receptor gene (FSHR) as independent predictive markers of ovarian response. Indeed, the tailoring of reproductive treatments is crucial for both maximizing the success of IVF patients and obtaining a reduction in hypo-or hyper-response rates. Methods This prospective, observational study analyzed the association of -29 and 2039 FSHR polymorphisms with the number of retrieved oocytes in 140 patients attending an IVF/ ICSI cycle for severe male factors (≤5,000,000 spermatozoa/ mL) or tubal factors at the ANDROS Day

show abstract

“…The introduction of GnRH antagonists presented hope for POR. GnRH antagonists can induce pituitary suppression within a few hours without a "flare-up" effect, and the suppression can be released immediately after their discontinuation [19]. In the present study, we investigated the effectiveness of the GnRH antagonist protocol in expected poor ovarian responders.…”

Section: Discussionmentioning

confidence: 99%

GnRH Antagonist Protocol: Is It Effective for Expected Poor Ovarian Responders with Tubal Factor Undergoing IVF?

Xing¹,

Lin²,

Zhang³

2017

ARSci

View full text Add to dashboard Cite

show abstract

Comparisons of GnRH antagonist versus GnRH agonist protocol in poor ovarian responders undergoing IVF

Cited by 108 publications

References 35 publications

A comparative study on oxidative and antioxidative markers of serum and follicular fluid in GnRH agonist and antagonist cycles

A comparative study on oxidative and antioxidative markers of serum and follicular fluid in GnRH agonist and antagonist cycles

The carriers of the A/G-G/G allelic combination of the c.2039 A>G and c.-29 G>A FSH receptor polymorphisms retrieve the highest number of oocytes in IVF/ICSI cycles

GnRH Antagonist Protocol: Is It Effective for Expected Poor Ovarian Responders with Tubal Factor Undergoing IVF?

Contact Info

Product

Resources

About