Comparison vitamin D serum levels in allergic rhinitis patients with normal population

Vatankhah, Venus; Lotfizadeh, Masoud; Iranpoor, Hamidreza; Jafari, Fatemeh; Khazraei, H R

doi:10.1016/j.reval.2016.10.009

Cited by 7 publications

(4 citation statements)

References 15 publications

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“…(p value-0.8919). Contrary to our findings, in the study done by Venus Vatankhah et al 10 there is a relationship between serum level of vitamin D and suffering from allergic rhinitis. Another study by Abdulbari Bener et al 13 also revealed a high prevalence of Vitamin D deficiency in children with asthma and allergic diseases Similar to our finding , among Allergic rhinitis, CRS with nasal polyps and CRS without nasal polyp groups compared with the control group were statistically not had significant differences in the hs-…”

Section: Discussioncontrasting

confidence: 99%

“…9 Some studies have shown that there is an association between severity of allergic rhinitis and serum level of 25 OH vitamin D & C-Reactive Protein, but no consensus has been yet achieved. 9,10 Therefore ,We conducted the present study was to compare the vitamin D3 status and C-reactive protein (CRP) among allergic rhinitis patients who were on treatment with either intranasal Fluticasone or oral…”

Section: Introductionmentioning

confidence: 99%

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Comparison of C-reactive protein and Vitamin D3 level among Patients of Allergic Rhinitis while on treatment with either Nasal Fluticasone or Combination Therapy of Montelukast and Levocetirizine: A Randomized Control Study

Chadha¹,

Kumar²

2022

IARJMS

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We conducted the present study to compare the vitamin D3 status and C-reactive protein (CRP) among allergic rhinitis patients who were on treatment with either intranasal Fluticasone or oral Levocetrizine and Montelukast therapy. Material and Methods: The study was a prospective randomized, single blinded, comparative, parallel group study, with two intervention groups conducted at Civil Hospital Jogindernagar of Himachal Pradesh, India. A total of Fifty patients diagnosed with allergic rhinitis was randomly allocated to either Group A receiving oral Montelukast and Levocetrizine or Group B receiving Fluticasone propionate aqueous nasal spray and followed up for 6 weeks. Vitamin D status and C-reactive protein (CRP) after 6 weeks was taken as primary outcome variables. Results: Among Group A , Recovery at 6 weeks was occurred in 9 (36%) patients while in Group B Recovery at 6 weeks was occurred in 17(68 %) patients.(p value 0.046). There was statistically significant lower mean CRP level was found in group B as compared to Group A (p value 0.003). Although, lower mean Vit D3 level was found in group B as compared to Group A but this difference was not found to be statistically significant. (p value 0.218). Although, lower mean CRP and higher mean Vit D3 level was found in recovered patients in group A as compared to who were not recovered but this difference was not found to be statistically significant(p value 0.198 and 0.324 respectively). Similarly,higher mean CRP and Vit D3 level was found in recovered patients in group B as compared to who were not recovered but this difference was not found to be statistically significant.( p value 0.804 andp value 0.418). Similarly ,in recovered patients there was no statistical significant difference in mean CRP and Vit D3 level(P value 0.9536 and 0.2486 respectively) in both groups, although the mean CRP and Vit D3 level were higher in Group A as compared to group B. But in non recovered patients, the mean CRP level was statistically higher in Group A as compared to group B(P value0.0029) while there was no statistical significant difference in Vit D3 level in both groups.(p value-0.8919). Conclusion: Study concluded that there was no statistical significant difference in mean Vitamin D3 and CRP levels in both groups as well as there was no significant association between Vitamin D3 and CRP levels and recovery status of patients in both groups.

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Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Comparison of C-reactive protein and Vitamin D3 level among Patients of Allergic Rhinitis while on treatment with either Nasal Fluticasone or Combination Therapy of Montelukast and Levocetirizine: A Randomized Control Study

Chadha¹,

Kumar²

2022

IARJMS

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“…Yenigun A. et al reported that the plasma level of vitamin D was lower in an allergic rhinitis group than in the control group (7.33 ± 3.61 ng/ml vs 13.37 ± 5.42 ng/ml) [13]. Vatankhah V. et al identified a lower mean serum level of 25(OH) vitamin D in an allergic rhinitis group (19.8 ± 7.4 ng/ml) than in the control group (224.9 ± 7.4 ng/ml) [14]. The authors reported that patients in the allergic rhinitis group were vitamin D deficient, but none of the subjects in the control group were vitamin D deficient.…”

Section: Discussionmentioning

confidence: 97%

Vitamin D Deficiency Is Correlated with Severity of Allergic Rhinitis

Sudiro¹,

Lestari²,

Madiadipoera³

et al. 2017

OALib

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Background: Vitamin D deficiency has been targeted as a cause of the increased incidence of allergic rhinitis. Many factors, including sun exposure, influence vitamin D levels. Indonesia is a country with abundant sunshine exposure throughout the year; therefore, Indonesian residents are not expected to have inadequate vitamin D levels. Objective: This study aimed to investigate whether vitamin D deficiency levels are correlated with disease spectrum among allergic rhinitis patients. Material and Method: A cross-sectional study was conducted in the Rhino-Allergy ORL-HNS Clinic at Dr. Hasan Sadikin General Hospital in Bandung, Indonesia, from March-June 2016. All subjects underwent skin prick tests and serum 25-hydroxy vitamin D levels examination. To measure the association between vitamin D deficiency level and severity of allergic rhinitis, a Rank-Spearman correlation test was used and significant level was determined when the p-value is <0.05. Results: A total of 46 allergic rhinitis patients (19 males, 27 females, aged 28.3 ± 6 years) were included in this study. 63% of allergic rhinitis patients had a severe vitamin D deficiency and 50% of them classified as having persistent moderate-severe based on ARIA-WHO classification. Vitamin D deficiency was found to be significantly correlated with severity of allergic rhinitis status (r s = −0.321; p = 0.005). Conclusion: We found vitamin D deficiency was correlated with allergic rhinitis classification and a significant proportion of allergic rhinitis patients showed a severe vitamin D deficiency.

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“…Particularly in allergic diseases, vitamin D acts on the human immune system through inhibitory functions on the growth cycle of human dendritic cells and the functions of T cells, stimulating the secretion of specific cytokines such as IL-10 [ 47 , 48 ]. It has been widely discussed how patients diagnosed with allergic disease are characterized by below normal levels of vitamin D and how this hormonal deficiency leads to a greater severity of symptoms [ 49 , 50 , 51 ]. In fact, the metabolite of vitamin D 1,25 (OH) 2VD3 can act by inhibiting T-helper 1 (TH1) and stimulating the responses of TH2 cells.…”

Section: Immunological Correlation Between Vd3 and Crswnp/crssnpmentioning

confidence: 99%

Role of Vitamin D in the Clinical Course of Nasal Polyposis

2021

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Vitamin D is a lipo-soluble hormone well known for its effects on calcium homeostasis and bone metabolism. Recently, there has been growing interest in the extraskeletal effects of vitamin D. In particular, recent studies have highlighted how vitamin D plays a fundamental role in immunomodulation processes in the context of both innate and adaptive immunity, with consequent anti-inflammatory and anti-oxidant effect in different immune-mediated pathologies, such as systemic sclerosis, psoriasis, atopic dermatitis and rheumatoid arthritis; as well as in various pro-inflammatory processes affecting the airways, including chronic rhinosinusitis with (CRSwNP) or without (CRSsNP) nasal polyposis. We analyze the role of vitamin D in the genesis and progression of CRSwNP/sNP and its supplementation as a safe and valid therapeutic strategy capable of improving the clinical outcome of standard therapies.

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Comparison vitamin D serum levels in allergic rhinitis patients with normal population

Cited by 7 publications

References 15 publications

Comparison of C-reactive protein and Vitamin D3 level among Patients of Allergic Rhinitis while on treatment with either Nasal Fluticasone or Combination Therapy of Montelukast and Levocetirizine: A Randomized Control Study

Comparison of C-reactive protein and Vitamin D3 level among Patients of Allergic Rhinitis while on treatment with either Nasal Fluticasone or Combination Therapy of Montelukast and Levocetirizine: A Randomized Control Study

Vitamin D Deficiency Is Correlated with Severity of Allergic Rhinitis

Role of Vitamin D in the Clinical Course of Nasal Polyposis

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