Comparison on gestation and lactation exposure of perfluorinated compounds for newborns

Liu, Jiaying; Li, Jingguang; Liu, Yong; Chan, Hing Man; Zhao, Yunfeng; Cai, Zongwei; Wu, Yongning

doi:10.1016/j.envint.2011.05.001

Cited by 148 publications

(153 citation statements)

References 48 publications

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“…In the present study, we found higher levels of PFCs in maternal serum than in cord serum, which is consistent with previous studies (Monroy et al 2008;Hanssen et al 2010;Beesoon et al 2011). Maternal and cord PFOS and PFOA concentrations were among the highest in Europe (Midasch et al 2007;Fei et al 2007;Needham et al 2011) and even among the highest in the world (Liu et al 2011;Kim et al 2011a, b;Beesoon et al 2011). Maternal and cord PFNA levels were lower than those measured in other countries (Monroy et al 2008;Needham et al 2011;Kim et al 2011a;Beesoon et al 2011).…”

Section: Discussionsupporting

confidence: 82%

“…PFCs have been shown to cross the placenta (Inoue et al 2004;Liu et al 2011;Gützkow et al 2012) and thus have a potential to exert a direct influence on the developing fetus (Apelberg et al 2007a;Fei et al 2007). According to previous studies, the median PFC concentrations in cord blood ranged from 30 to 130% of the maternal concentrations (Liu et al, 2011, Kim et al 2011a, Gützkow et al 2012).…”

Section: Introductionmentioning

confidence: 99%

“…According to previous studies, the median PFC concentrations in cord blood ranged from 30 to 130% of the maternal concentrations (Liu et al, 2011, Kim et al 2011a, Gützkow et al 2012). PFCs have also been shown to be transmitted to the neonate through breast milk (Kärrman et al 2007;Sundström et al 2011).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Determinants of maternal and fetal exposure and temporal trends of perfluorinated compounds

Ode

Rylander

Lindh

et al. 2013

Environ Sci Pollut Res

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Section: Discussionsupporting

confidence: 82%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Determinants of maternal and fetal exposure and temporal trends of perfluorinated compounds

Ode

Rylander

Lindh

et al. 2013

Environ Sci Pollut Res

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“…1. The median PFHxS level of cord serum in this study (3.87 ng/mL) is much higher than those found in most reported findings, such as South Africa (0.3 ng/mL) (Hanssen et al 2010), Spain (0.4 ng/mL) (Manzano-Salgado et al 2015), Korea (0.57 ng/mL in 2011) , and China (0.06 ng/mL) (Liu et al 2011). However, consistent with our results, an investigation from the Faroe Islands (Needham et al 2011) collected 15 sets of maternal and cord blood, and milk in 2000, showing that PFHxS levels in cord serum (9.1 ng/mL) were higher than PFOS (6.6 ng/mL) or PFOA (3.1 ng/mL).…”

Section: The Pfass Concentration In Cord Serumcontrasting

confidence: 77%

Perfluoroalkyl substances with isomer analysis in umbilical cord serum in China

Zhang

Zeng

Qian

et al. 2017

Environ Sci Pollut Res

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Perfluoroalkyl substances (PFASs) are a class of widely used chemicals that have been detected in the environment and general population. However, the isomer patterns in human are poorly characterized. Previous studies observed the isomer-specific maternal-fetal transfer of PFASs in human. In our current study, we first examined the profile of PFASs and isomers, including 17 linear PFASs and 10 branched PFOS/PFOA isomers by using isotopic internal standards in umbilical cord serum samples from Guangzhou, China. We collected a total of 321 of cord blood serum samples from July to October in 2013, and analyzed the PFASs concentration with isomer-specific PFASs analysis method. The results showed that 9 out of 17 PFASs (linear PFASs) were detected (>50% detection rate). Perfluorohexane sulfonate (PFHxS, median 3.87 ng/mL) was the predominant, followed by total PFOS (median 2.99 ng/mL) and total PFOA (median 1.23 ng/mL) in cord serum. In addition, 1m-, iso-, ∑3+4+5m-PFOS and iso-PFOA were the branched PFASs detected in the current study. The proportion of linear PFOS (n-PFOS) was 75.16% of ∑PFOS which was similar to the proportion of electrochemical fluorination that produces ca. 70% linear PFOS and 30% branched. On the contrary, linear PFOA (n-PFOA) accounted for 98.69% ∑PFOA in cord serum samples. Our finding indicates distinct PFASs and PFOS/PFOA isomer profile in cord serum, suggesting there might be a different exposure pathway and metabolism of PFASs.

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“…Mean concentrations of PFOS and PFOA were 3.2 and 1.66 ng mL À1 in maternal serum, 1.79 and 1.5 ng mL À1 in cord serum, 0.06 and 0.18 ng mL À1 in breast milk, respectively. So the efficiency of transport through both placental barrier and lactation was relatively higher for PFOA than PFOS (Liu et al, 2011a). Concentration of PFOA in breast milk was usually observed at least 10-fold less than that in matched maternal serum (Liu et al, , 2011a.…”

Section: Exposure Pathway and Risk Assessmentmentioning

confidence: 95%

A review of sources, multimedia distribution and health risks of perfluoroalkyl acids (PFAAs) in China

et al. 2015

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Comparison on gestation and lactation exposure of perfluorinated compounds for newborns

Cited by 148 publications

References 48 publications

Determinants of maternal and fetal exposure and temporal trends of perfluorinated compounds

Determinants of maternal and fetal exposure and temporal trends of perfluorinated compounds

Perfluoroalkyl substances with isomer analysis in umbilical cord serum in China

A review of sources, multimedia distribution and health risks of perfluoroalkyl acids (PFAAs) in China

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