Comparison of zirconia and titanium implants after a short healing period. A pilot study in minipigs

Stadlinger, Bernd; Hennig, Maria; Eckelt, Uwe; Kuhlisch, Eberhard; Mai, Ronald

doi:10.1016/j.ijom.2010.01.015

Cited by 76 publications

(50 citation statements)

References 24 publications

(28 reference statements)

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“…The % BIC measured in the present research showed slightly higher values of zirconia implants compared with other reported animal studies [28, 29]. We used the sheep femoral site in our study to model maxillary bone in human patients, which is trabecular and cancellous in nature.…”

Section: Discussionmentioning

confidence: 43%

One-Piece Zirconia Ceramic versus Titanium Implants in the Jaw and Femur of a Sheep Model: A Pilot Study

Siddiqi

Duncan

Silva

et al. 2016

BioMed Research International

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Reports have documented titanium (Ti) hypersensitivity after dental implant treatment. Alternative materials have been suggested including zirconia (Zr) ceramics, which have shown predictable osseointegration in animal studies and appear free of immune responses. The aim of the research was to investigate the bone-to-implant contact (BIC) of one-piece Zr, compared with one-piece Ti implants, placed in the jaws and femurs of domestic sheep. Ten New Zealand mixed breed sheep were used. A One-piece prototype Ti (control) and one Zr (test) implant were placed in the mandible, and one of each implant (Ti and Zr) was placed into the femoral epicondyle of each animal. The femur implants were submerged and unloaded; the mandibular implants were placed using a one-stage transgingival protocol and were nonsubmerged. After a healing period of 12 weeks, %BIC was measured. The overall survival rate for mandibular and femur implants combined was 87.5%. %BIC was higher for Zr implants versus Ti implants in the femur (85.5%, versus 78.9%) (p = 0.002). Zirconia implants in the mandible showed comparable %BIC to titanium implants (72.2%, versus 60.3%) (p = 0.087). High failure rate of both Zr and Ti one-piece implants in the jaw could be attributed to the one-piece design and surface characteristics of the implant that could have influenced osseointegration. Further clinical trials are recommended to evaluate the performance of zirconia implants under loading conditions.

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Section: Discussionmentioning

confidence: 43%

One-Piece Zirconia Ceramic versus Titanium Implants in the Jaw and Femur of a Sheep Model: A Pilot Study

Siddiqi

Duncan

Silva

et al. 2016

BioMed Research International

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“…Ceramic implants made of zirconia already are available to a small segment of the global market. A few short-term clinical reports on zirconia implants are available 6) , but most evidence comes from preclinical studies in pigs 7,8) , dogs 9) and rabbits 10) . In vitro research on zirconia was initiated in an attempt to understand the role of wear particles in aseptic loosening of hip prostheses 11) .…”

Section: Introductionmentioning

confidence: 99%

Acid and alkali etching of grit blasted zirconia: Impact on adhesion and osteogenic differentiation of MG63 cells in vitro

et al. 2012

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There is a need for evaluating zirconia surface modifications and their potential impact on the biological response of osteogenic cells. Grit blasted zirconia discs were either left untreated or underwent acid or alkaline etching. Adhesion and osteogenic differentiation of MG63 cells was determined after one week of culture. The macro-scaled roughness of the grit blasted zirconia discs, independent of the surface treatment, was within a narrow range and only slightly smoother than titanium discs. However, the alkaline-and acid-etching led to an increase of the micro-roughness of the surface. The surface modifications had no effect on cell spreading and did not cause significant change in the expression of differentiation markers. Thus, in this respective setting, morphologic changes observed upon treatment of grit blasted zirconia discs with acid or alkaline do not translate into changes in MG63 cell adhesion or differentiation and are comparable to findings with anodized titanium discs.

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“…28 Another study in miniature pigs 26 concluded that TiZr alloy with a hydrophilic, sandblasted and acid-etched surface showed similar or even stronger bone tissue responses than the Ti control, while another study in miniature pigs suggested that unloaded, sandblasted ZrO 2 and sandblasted and acid-etched Ti implants osseointegrated comparably within a healing period of four weeks. 29 Unfortunately, no studies on these different materials have been found geared towards a comparison of the infection-resistance of osseointegration.…”

Section: Discussionmentioning

confidence: 99%

“…26 ZrO 2 ceramics are also used as an alternative for Ti due to their high mechanical strength, chemical stability and resistance to corrosion, in addition to their aesthetic advantage of better matching the natural tooth colour. 27 Ti alloys and ZrO 2 have all been compared with Ti for their osseointegrative properties, either in miniature pigs 26,28,29 or rabbits 30 for periods of time up to 2 months. In general, 31 these studies are low-powered.…”

Section: Introductionmentioning

confidence: 99%

Osteoblast integration of dental implant materials after challenge by sub-gingival pathogens: a co-culture study in vitro

et al. 2015

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Sub-gingival anaerobic pathogens can colonize an implant surface to compromise osseointegration of dental implants once the soft tissue seal around the neck of an implant is broken. In vitro evaluations of implant materials are usually done in monoculture studies involving either tissue integration or bacterial colonization. Co-culture models, in which tissue cells and bacteria battle simultaneously for estate on an implant surface, have been demonstrated to provide a better in vitro mimic of the clinical situation. Here we aim to compare the surface coverage by U2OS osteoblasts cells prior to and after challenge by two anaerobic sub-gingival pathogens in a co-culture model on differently modified titanium (Ti), titanium-zirconium (TiZr) alloys and zirconia surfaces. Monoculture studies with either U2OS osteoblasts or bacteria were also carried out and indicated significant differences in biofilm formation between the implant materials, but interactions with U2OS osteoblasts were favourable on all materials. Adhering U2OS osteoblasts cells, however, were significantly more displaced from differently modified Ti surfaces by challenging sub-gingival pathogens than from TiZr alloys and zirconia variants. Combined with previous work employing a co-culture model consisting of human gingival fibroblasts and supra-gingival oral bacteria, results point to a different material selection to stimulate the formation of a soft tissue seal as compared to preservation of osseointegration under the unsterile conditions of the oral cavity.

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Comparison of zirconia and titanium implants after a short healing period. A pilot study in minipigs

Cited by 76 publications

References 24 publications

One-Piece Zirconia Ceramic versus Titanium Implants in the Jaw and Femur of a Sheep Model: A Pilot Study

One-Piece Zirconia Ceramic versus Titanium Implants in the Jaw and Femur of a Sheep Model: A Pilot Study

Acid and alkali etching of grit blasted zirconia: Impact on adhesion and osteogenic differentiation of MG63 cells in vitro

Osteoblast integration of dental implant materials after challenge by sub-gingival pathogens: a co-culture study in vitro

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