Comparison of wound-bursting strengths and surface characteristics of FDA-approved tissue adhesives for skin closure

Abstract

2004) Comparison of woundbursting strengths and surface characteristics of FDA-approved tissue adhesives for skin closure , Abstract-We compared the wound-bursting strength (WBS), mode of adhesive failure and surface characteristicsof two FDA-approved tissue adhesives for skin closure in an incisional rat model using a randomized, controlled, blind animal experiment. Standardized 2-cm full-thickness incisions were made in duplicate on both sides of 15 rats and closed with Indermil, or High Viscosity Dermabond (HVD) following manufacturers' instructions. WBS was measured 5 min later with a validated commercial instrument. Wound sections were also observed under light and scanning electron microscopies. Indermil was signi cantly weaker than HVD (mean difference, 143 mmHg; 95% CI, 42-229 mmHg, P D 0:002). The mode of failure for Indermil was primarily cohesive in the adhesive and the primary failure mode for the HVD was interfacial (Â 2 , P < 0:01). Microscopic observations demonstrated that application of HVD resulted in a thick, uniform and smooth surface while Indermil resulted in a thin, irregular, cracked surface. We conclude that HVD is stronger, thicker and more uniform than Indermil.

An In-Vivo Study of the Wound-Bursting Strengths of Octyl-Cyanoacrylate, Butyl-Cyanoacrylate, and Surgical Tape in Rats

“…Furthermore, butyl-cyanoacrylate was found to be significantly stronger than the adhesive tapes. These findings are in agreement with a prior similar study in which the WBS of another butyl-cyanoacrylate (Indermil) was compared to that of octyl-cyanoacrylate (11). In this study, the WBS of the octyl-cyanoacrylate was also significantly greater than that of the butyl-cyanoacrylate (358 vs. 215 mm Hg, respectively, p ϭ 0.002).…”

“…The proportion of wound failures due to peel or split of the adhesive are expressed as percent frequency of occurrence and are compared with chisquared tests. This study had 80% power to detect a 75-mm Hg between-group difference in WBS (twotailed ␣ ϭ 0.05) (11). We felt that a smaller difference in bursting strength would not be clinically relevant.…”

Magnetic Retraction of Bowel by Intraluminal Injectable Cyanoacrylate-Based Magnetic Glue

“…All are topical skin adhesives made of octyl-cyanoacrylate or butyl-cyanoacrylate glues [19]. Since temperatures of 42°C and above are known to damage tissues [20], the extent of maximal heat generation during glue polymerisation was investigated.…”

In Vivo Study of Wound Bursting Strength and Compliance of Topical Skin Adhesives

“…9 Measurements were made immediately after wound closure and drying of the adhesive and at 1 and 2 days after closure. At each time point, 14 wounds from each adhesive group were tested for in vivo WBS, and another 14 from each group were tested for tissue adhesive compliance.…”