Magnetic Retraction of Bowel by Intraluminal Injectable Cyanoacrylate-Based Magnetic Glue

Wang, Zhigang; Brown, Andrew W.; André, Pascal; Brown, Stuart I.; Florence, Gordon J.; Cuschieri, Alfred

doi:10.1155/2013/526512

Cited by 6 publications

(5 citation statements)

References 34 publications

(41 reference statements)

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“…1c. The morphologies and magnetisation curves for the commercial stainless steel microparticles were reported earlier elsewhere [13]. As expected, the curves are symmetric and the magnetisation at saturation, Ms, can be deduced from the plateau, when the magnetisation does not increase any more with the magnetic field.…”

Section: Characterisation Of Magnetic Particlessupporting

confidence: 72%

“…The probe applies initial suction through small suction holes at its distal end before its long needle (19-gauge) is inserted, via a central channel of the probe, into the lumen of the bowel for injection of ferrofluid in large volume. More detailed illustration of our proposed transperitoneal injection can be found from our recently published glue-based magnetic fluid for bowel magnetisation and retraction [13]. This design facilitates intraluminal injection without the need for use of additional graspers.…”

Section: Preparation Of Magnetic Ferrofluids For Intra-luminal Bowel mentioning

confidence: 99%

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Intraluminal magnetisation of bowel by ferromagnetic particles for retraction and manipulation by magnetic probes

Wang

André

McLean

et al. 2014

Medical Engineering & Physics

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Feasibility studies are needed to demonstrate that safe and effective manipulation of bowel during Minimal Access Surgery (MAS) can be obtained by use of magnetic force. This paper characterises two classes of magnetic particles: stainless steel microparticles (SS-μPs) and iron oxide nanoparticles (IO-nPs) in terms of their magnetisation, chemical composition, crystallinity, morphology and size distribution. Both magnetic particles were dispersed in a high viscosity biological liquid for intraluminal injection of bowel. Ex vivo porcine bowel segments were then retracted by permanent magnetic probes of 5.0 and 10mm diameter. Strong retraction forces reaching 6N maximum were obtained by magnetic fluid based on dispersion of SS-μPs. In contrast, the IO-nP-based magnetic liquid generated less attraction force, due to both lower magnetic and solution properties of the IO-nPs. The comparison of the two particles allowed the identification of the rules to engineer the next generation of particles. The results with SS-μPs provide proof on concept that intraluminal injection of magnetic fluid can generate sufficient force for efficient bowel retraction. Thereafter we shall carry out in vivo animal studies for efficacy and safety of both types of ferrofluids.

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Section: Characterisation Of Magnetic Particlessupporting

confidence: 72%

Section: Preparation Of Magnetic Ferrofluids For Intra-luminal Bowel mentioning

confidence: 99%

Intraluminal magnetisation of bowel by ferromagnetic particles for retraction and manipulation by magnetic probes

Wang

André

McLean

et al. 2014

Medical Engineering & Physics

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“…In particular, the ceramic bioglass greatly promoted coagulation and exhibited remarkable adhesive properties. Wang et al prepared a magnetic adhesive from steel microparticles and a cyanoacrylate adhesive (Loctite 4014) [ 608 ]. Intraluminal injection of the magnetic adhesive into ex vivo porcine colonic segments and a magnet at the injection site resulted in polymerization of an intraluminal, mucosally adherent coagulum that allows adequate retraction of the bowel with little tissue trauma during minimally invasive surgery.…”

Section: Other Soft Tissue Regeneration and Engineeringmentioning

confidence: 99%

Iron Oxide Nanoparticles in Regenerative Medicine and Tissue Engineering

2021

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In recent years, many promising nanotechnological approaches to biomedical research have been developed in order to increase implementation of regenerative medicine and tissue engineering in clinical practice. In the meantime, the use of nanomaterials for the regeneration of diseased or injured tissues is considered advantageous in most areas of medicine. In particular, for the treatment of cardiovascular, osteochondral and neurological defects, but also for the recovery of functions of other organs such as kidney, liver, pancreas, bladder, urethra and for wound healing, nanomaterials are increasingly being developed that serve as scaffolds, mimic the extracellular matrix and promote adhesion or differentiation of cells. This review focuses on the latest developments in regenerative medicine, in which iron oxide nanoparticles (IONPs) play a crucial role for tissue engineering and cell therapy. IONPs are not only enabling the use of non-invasive observation methods to monitor the therapy, but can also accelerate and enhance regeneration, either thanks to their inherent magnetic properties or by functionalization with bioactive or therapeutic compounds, such as drugs, enzymes and growth factors. In addition, the presence of magnetic fields can direct IONP-labeled cells specifically to the site of action or induce cell differentiation into a specific cell type through mechanotransduction.

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“…An interesting solution for magnetic retraction of bowel by intraluminal injectable cyanoacrylate-based magnetic glue has been proposed by Wang et al [13]. Results showed that with an injected volume of 2 ml and with a particle concentration of 1 g/ml, the technique produced maximal magnetic retraction forces of 2.24 ± 0.23 N and 5.11 ± 0.34 N, with use of 5 and 10 mm probes, respectively [13].…”

Section: Magnetically Driven Medical Devicesmentioning

confidence: 99%

Magnetically driven medical devices: a review

Sliker

Ciuti

Rentschler

et al. 2015

Expert Review of Medical Devices

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A widely accepted definition of a medical device is an instrument or apparatus that is used to diagnose, prevent or treat disease. Medical devices take a broad range of forms and utilize various methods to operate, such as physical, mechanical or thermal. Of particular interest in this paper are the medical devices that utilize magnetic field sources to operate. The exploitation of magnetic fields to operate or drive medical devices has become increasingly popular due to interesting characteristics of magnetic fields that are not offered by other phenomena, such as mechanical contact, hydrodynamics and thermodynamics. Today, there is a wide range of magnetically driven medical devices purposed for different anatomical regions of the body. A review of these devices is presented and organized into two groups: permanent magnetically driven devices and electromagnetically driven devices. Within each category, the discussion will be further segregated into anatomical regions (e.g., gastrointestinal, ocular, abdominal, thoracic, etc.).

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Magnetic Retraction of Bowel by Intraluminal Injectable Cyanoacrylate-Based Magnetic Glue

Cited by 6 publications

References 34 publications

Intraluminal magnetisation of bowel by ferromagnetic particles for retraction and manipulation by magnetic probes

Intraluminal magnetisation of bowel by ferromagnetic particles for retraction and manipulation by magnetic probes

Iron Oxide Nanoparticles in Regenerative Medicine and Tissue Engineering

Magnetically driven medical devices: a review

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