Comparison of WBC, ESR, CRP and PCT serum levels in septic and non-septic burn cases

Barati, Mitra; Alinejad, Faranak; Bahar, Mohammad Ali; Tabrisi, Mahbobe Satarzadeh; Shamshiri, Ahmad Reza; Bodouhi, Nosrat-ol-lahe; Karimi, Hamid

doi:10.1016/j.burns.2008.01.014

Cited by 140 publications

(124 citation statements)

References 29 publications

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“…But, other investigators suggested that PCT may be a useful marker for the diagnosis of severe infectious complications after burn [17,20,22,25,26]. Our results were in concordance with the results of Lavrentieva et al [19] and Barati et al [13]. PCT levels of our PG on day 1 were at local infection levels (0.5 ng/mL) due to the burn trauma.…”

Section: Discussionsupporting

confidence: 93%

“…Budkevich et al [23] suggested the rise in their PCT levels may be related with bacterial complications. Barati et al [13] studied with 60 burn patients with and without infection. They detected a signifi cantly higher PCT level in the infected group as in our one patient with sepsis and elevated PCT level (5.19 ng/mL).…”

Section: Discussionmentioning

confidence: 99%

“…The method specifi c to the PCT molecule uses two separate monoclonal antibodies binding to the calcitonin and catacalcin regions. The minimum value detected by this method was 0.1 ng/mL and the measuring range was 0.1-500 ng/mL, while the pathological limit was >0.5 ng/mL [13,17]. A commercial ELISA kit (Neopterin ELISA, DRG Instruments GmbH, Berlin, Germany) was used according to the manufacturer's instructions to quantitatively determine the serum neopterin levels.…”

Section: Laboratory Testsmentioning

confidence: 99%

“…White blood cell (WBC), C-reactive protein (CRP), sedimentation rate, or high fever are non-specifi c markers [13]. CRP is regarded as an infection marker, especially in acute bacterial infections [14].…”

Section: Introductionmentioning

confidence: 99%

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Serum Neopterin and Procalcitonin Levels in Relationship with Pediatric Burn Wound Infections

Pilancı¹,

Erǧin²,

Sirekbasan³

et al. 2016

Acta Microbiologica et Immunologica Hungarica

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Infection and septic complications in burn patients can be monitored by procalcitonin (PCT) and neopterin plasma values. The aim of the study was to investigate serum neopterin and PCT levels with WBC (white blood cell) and CRP (C-reactive protein) levels in patient group (PG) and healthy control group (HCG) and to investigate the relationship of these markers with burn wound infections (BWI). As the PG, 23 patients between 0-12 ages and up to 30% Total Body Surface Area (TBSA) burned and 15 HCG were included. PCT, neopterin, WBC, and CRP results on the fi rst, the seventh, the fourteenth and the 21 st day have been compared. During the follow-up period, 11 patients with BWI and 12 patients without BWI were classifi ed as infected and non-infected patients, respectively. PCT and neopterin levels were detected higher in patients with BWI but no signifi cant difference were present. Also, PCT and neopterin levels within the fi rst 24 hours following the burn were detected higher in PG than HCG. CRP and WBC levels were detected high due to burn trauma. PCT and neopterin levels were increased in patients with BWI. PCT levels were increased during the pre-infectious period, while neopterin levels increased during the post-infectious period.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Laboratory Testsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Serum Neopterin and Procalcitonin Levels in Relationship with Pediatric Burn Wound Infections

Pilancı¹,

Erǧin²,

Sirekbasan³

et al. 2016

Acta Microbiologica et Immunologica Hungarica

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“…An important factor that indirectly affects life conditions of the studied population, which can be related to nutritional behavior, is the low level of formal education (Table 2). In the present study, the most prevalent study level was basic education previous studies (15)(16)(17). Serum erythrocytes, hemoglobin and hematocrit, in the present study, had dropped by the second moment, subsequent to blood loss from curatives or debridement.…”

Section: Introductionsupporting

confidence: 45%

Nutritional, immunological and microbiological profiles of burn patients

Barbosa¹,

Calvi²,

Pereira³

2009

J. Venom. Anim. Toxins incl. Trop. Dis

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ABSTRACT:A burn is a lesion on an organic tissue resultant from direct or indirect action of heat on the organism. The present study aimed to evaluate the nutritional, immunological and microbiological status of burn patients at the Bauru State Hospital, São Paulo state, Brazil, in 2007. Eight patients, aged more than 18 years and injured up to 24 hours, were evaluated at the moment of hospitalization and seven days later. All victims were males with a mean age of 38 years. On average, 17.5% of their body surfaces were burned and 50% of the patients were eutrophic. There were significant alterations in levels of erythrocytes, hemoglobin, hematocrit, total protein and albumin due to increased endothelial permeability, direct destruction of proteins in the heat-affected area and blood loss from lesions or debridement. At a second moment, cytokines IL-6 and TNF-α had augmented significantly, with IL-6 presenting elevated levels in relation to controls at the first moment. Microbiological analysis showed that 100% of the samples collected at hospital admission were negative and after one week Staphylococcus aureus was found in all cultures. Therefore, a burn patient may be considered immunosuppressed and these results indicate significant nutritional, immunological and microbiological alterations that can interfere in his recovery.

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Serum Procalcitonin, Hematology Parameters, and Cell Morphology in Multiple Clinical Conditions and Sepsis

Feng,

He,

Guan

et al. 2024

Clinical Laboratory Analysis

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BackgroundThe clinical value of procalcitonin (PCT) in infection diagnosis and antibiotic stewardship is still unclear. This study aimed to investigate the association between serum PCT and different clinical conditions as well as other infectious/inflammatory parameters in different septic patients in order to elucidate the value of PCT detection in infection management.MethodsChemiluminescence immunoassay was used for serum PCT analysis. Hematology analysis was used for complete blood cell count. Digital automated cell morphology analysis was used for blood cell morphology examination. Blood, urine, and stool cultures were performed according to routine clinical laboratory standard operating procedures. C‐reactive protein (CRP) was analyzed by immunoturbidimetry. Erythrocyte sedimentation rate test was performed using natural sedimentation methods.ResultsOutpatients, ICU patients, and patients under 2 years of age with respiratory infections had higher serum PCT levels. Septic patients had the highest‐serum PCT levels and other infection indexes. PCT levels in the blood, urine, and stool culture‐positive patients were significantly higher than in culture‐negative patients. The neutrophil granulation and reactive lymphocytes were observed together with the PCT‐level increments in different septic patients, and these alterations were lessened after treatment. There was no significant change in monocyte morphology between pre‐ and posttreatment septic patients.ConclusionsSerum PCT is associated with neutrophil cytotoxicity and lymphocyte morphology changes in sepsis; thus, the combination of neutrophil and lymphocyte digital cell morphology evaluations with PCT detection may be a useful examination for guiding the clinical management of sepsis.

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Comparison of WBC, ESR, CRP and PCT serum levels in septic and non-septic burn cases

Cited by 140 publications

References 29 publications

Serum Neopterin and Procalcitonin Levels in Relationship with Pediatric Burn Wound Infections

Serum Neopterin and Procalcitonin Levels in Relationship with Pediatric Burn Wound Infections

Nutritional, immunological and microbiological profiles of burn patients

Serum Procalcitonin, Hematology Parameters, and Cell Morphology in Multiple Clinical Conditions and Sepsis

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