Comparison of various methods for quantification of apparent diffusion coefficient of head and neck lesions with HASTE diffusion-weighted MR imaging

Sakamoto, Junichiro; Sasaki, Yasutsuna; Otonari-Yamamoto, Mika; Sano, Tsukasa

doi:10.1016/j.oooo.2012.03.015

Cited by 17 publications

(13 citation statements)

References 22 publications

(56 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An echo-planar sequence is the traditional choice for DWI, and it readily yield images with a low signal-to-noise ratio and strong susceptibility artifacts and distortion[19], [25]–[27]. A turbo spin-echo (TSE)-based DW sequence does not suffer from susceptibility artifacts[19], [25]–[27].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Differentiating Laryngeal Carcinomas from Precursor Lesions by Diffusion-Weighted Magnetic Resonance Imaging at 3.0 T: A Preliminary Study

et al. 2013

View full text Add to dashboard Cite

BackgroundDiffusion-weighted magnetic resonance imaging (DWI) has been introduced in head and neck cancers. Due to limitations in the performance of laryngeal DWI, including the complex anatomical structure of the larynx leading to susceptibility effects, the value of DWI in differentiating benign from malignant laryngeal lesions has largely been ignored. We assessed whether a threshold for the apparent diffusion coefficient (ADC) was useful in differentiating preoperative laryngeal carcinomas from precursor lesions by turbo spin-echo (TSE) DWI and 3.0-T magnetic resonance.MethodsWe evaluated DWI and the ADC value in 33 pathologically proven laryngeal carcinomas and 17 precancerous lesions.ResultsThe sensitivity, specificity, and accuracy were 81.8%, 64.7%, 76.0% by laryngostroboscopy, respectively. The sensitivity, specificity, and accuracy of conventional magnetic resonance imaging were 90.9%, 76.5%, 86.0%, respectively. Qualitative DWI analysis produced sensitivity, specificity, and accuracy values of 100.0, 88.2, and 96.0%, respectively. The ADC values were lower for patients with laryngeal carcinoma (mean 1.195±0.32×10−3 mm2/s) versus those with laryngeal precancerous lesions (mean 1.780±0.32×10−3 mm2/s; P<0.001). ROC analysis showed that the area under the curve was 0.956 and the optimum threshold for the ADC was 1.455×10−3 mm2/s, resulting in a sensitivity of 94.1%, a specificity of 90.9%, and an accuracy of 92.9%.ConclusionsDespite some limitations, including the small number of laryngeal carcinomas included, DWI may detect changes in tumor size and shape before they are visible by laryngostroboscopy. The ADC values were lower for patients with laryngeal carcinoma than for those with laryngeal precancerous lesions. The proposed cutoff for the ADC may help distinguish laryngeal carcinomas from laryngeal precancerous lesions.

show abstract

Section: Introductionmentioning

confidence: 99%

“…A turbo spin-echo (TSE)-based DW sequence does not suffer from susceptibility artifacts[19], [25]–[27]. At our hospital, TSE DWI and linear regression with gradient b-values of 0 and 1,000 s/mm 2 for ADC measurement are used.…”

Section: Introductionmentioning

confidence: 99%

Differentiating Laryngeal Carcinomas from Precursor Lesions by Diffusion-Weighted Magnetic Resonance Imaging at 3.0 T: A Preliminary Study

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Routine magnetic resonance imaging (MRI) is a time-consuming method, which is sensitive to differences between examiners and may require the use of contrast material. With development of rapid MRI sequences (such as echo-planar [EPI], fast advanced spin echo [FASE], split echo acquisition of fast spin echo [SPLICE]), the sensitivity to susceptibility artifacts limiting the use of MRI for the head and neck region and limitations linked to duration have been significantly reduced (2,3).…”

mentioning

confidence: 99%

Diffusion-weighted imaging in the head and neck region: usefulness of apparent diffusion coefficient values for characterization of lesions

Şerifoğlu

Öz²,

Damar³

et al. 2015

Diagn Interv Radiol

View full text Add to dashboard Cite

ORIGINAL ARTICLE PURPOSEWe aimed to evaluate the role of apparent diffusion coefficient (ADC) values calculated from diffusion-weighted imaging for head and neck lesion characterization in daily routine, in comparison with histopathological results. METHODSNinety consecutive patients who underwent magnetic resonance imaging (MRI) at a university hospital for diagnosis of neck lesions were included in this prospective study. Diffusion-weighted echo-planar MRI was performed on a 1.5 T unit with b factor of 0 and 1000 s/mm 2 and ADC maps were generated. ADC values were measured for benign and malignant whole lesions seen in daily practice. RESULTS Diagnosis of head and neck lesions is difficult due to the complicated anatomic structure and different histological components of the many tissues that the neck contains. Imaging of head and neck lesions is not only important for diagnosis of lesions, but also for differentiation of benign lesions from malignant lesions and staging of tumors. While conventional imaging methods mainly evaluate morphological properties, their value is limited in recognizing prognostic characteristics such as benign-malignant differentiation of lesions (1). Routine magnetic resonance imaging (MRI) is a time-consuming method, which is sensitive to differences between examiners and may require the use of contrast material. With development of rapid MRI sequences (such as echo-planar [EPI], fast advanced spin echo [FASE], split echo acquisition of fast spin echo [SPLICE]), the sensitivity to susceptibility artifacts limiting the use of MRI for the head and neck region and limitations linked to duration have been significantly reduced (2, 3).Diffusion-weighted magnetic resonance imaging (DW-MRI) is a short sequence produced from EPI, FASE, SPLICE sequences. DW-MRI is sensitive to the randomized (Brownian) motion of water molecules at a microscopic level, which provides functional information about tissues. DW-MRI was initially used to diagnose early stroke in the brain and to evaluate brain masses (4-6). Previous studies have shown that rapid growth of high-grade tumors like astrocytoma and lymphoma causes hypercellularity, which leads to limitation of the diffusion of water molecules. Nowadays, apparent diffusion coefficient (ADC) maps calculated from DW-MRI sequences are being increasingly used to provide quantitative data for head and neck lesion diagnosis. In malignant lesions, the DW-MRI signal increases and signal loss is observed on ADC maps (5,7,8). Many researchers benefited from this feature of DW-MRI and evaluated the effectiveness of DW-MRI for head and neck lesion identification, benign-malignant differentiation, and characterization of malignant lesions (9-11).In this prospective study, head and neck lesions that are seen in daily routine were evaluated using DW-MRI, and the role of ADC values in lesion characterization was investigated with the guidance of histopathological results. Methods PatientsFrom January 2012 to January 2014, 90 consecutive patients underwent MRI for diag...

show abstract

“…[3] Diffusion weighted MR imaging (DWI) is a fast sequence constructed from fast advanced spin echo and echo-planar imaging (EPI). [4] DWI allows a quantitative index of water diffusivity for each voxel that provides visualization of the microscopic motion of water molecules within tissues. [5] Furthermore, some reports showed the application of DWI with calculation of apparent diffusion coefficient (ADC) in the differentiation between malignant and benign diseases in head and neck.…”

Section: Introductionmentioning

confidence: 99%

Changes of cerebrospinal fluid in the upper neck area with age using diffusion weighted MR imaging

Ogura¹,

Oda²,

Sue³

et al. 2018

IJDI

View full text Add to dashboard Cite

Purpose: Few studies have concerned the absolute apparent diffusion coefficient (ADC) values in the normal cerebrospinal fluid in the upper neck area and the effect of aging on diffusion. The purpose of this study was to evaluate changes of cerebrospinal fluid in the upper neck area with age using diffusion weighted MR imaging (DWI). Methods and methods: Our study included 160 patients who underwent MR imaging for oral and maxillofacial diseases. All patients were examined by DWI with 2 b values (0 and 800 sec/mm 2 ) at 1.5 Tesla and ADC maps. The cerebrospinal fluid and spinal cord in the upper neck area were analyzed using the ADC values and age.Results: ADC value of cerebrospinal fluid was significantly correlated to ADC value of spinal cord (R 2 = 0.141, p = .000). ADC value of spinal cord had no relation to age (R 2 = 0.015, p = .125). ADC value of cerebrospinal fluid had significant relation to age (R 2 = 0.026, p = .042). Conclusions:We indicated the changes of cerebrospinal fluid in the upper neck area with age using DWI. The data reported herein are representative, and the ADC values can be used for reference in future studies and in clinical settings.

show abstract

Comparison of various methods for quantification of apparent diffusion coefficient of head and neck lesions with HASTE diffusion-weighted MR imaging

Cited by 17 publications

References 22 publications

Differentiating Laryngeal Carcinomas from Precursor Lesions by Diffusion-Weighted Magnetic Resonance Imaging at 3.0 T: A Preliminary Study

Differentiating Laryngeal Carcinomas from Precursor Lesions by Diffusion-Weighted Magnetic Resonance Imaging at 3.0 T: A Preliminary Study

Diffusion-weighted imaging in the head and neck region: usefulness of apparent diffusion coefficient values for characterization of lesions

Changes of cerebrospinal fluid in the upper neck area with age using diffusion weighted MR imaging

Contact Info

Product

Resources

About