Comparison of various adiposity indexes in women with polycystic ovary syndrome and normo-ovulatory non-hirsute women: a population-based study

Tehrani, Fahimeh Ramezani; Minooee, Sonia; Azizi, Fereidoun

doi:10.1530/eje-14-0094

Cited by 40 publications

(22 citation statements)

References 54 publications

(64 reference statements)

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“…We found that LAP index was significantly higher in PCOS than in control women and it strongly correlated with insulin and HOMA index. The significant increased LAP index value in PCOS patients is in accordance with literature concerning this index as a good indicator of insulin resistance states 34,35 . Moreover, Nascimento et al .…”

Section: Discussionsupporting

confidence: 91%

Association Between Vitamin D and Adrenal Parameters with Metabolic and Inflammatory Markers in Polycystic Ovary Syndrome

Maidana

Fritzler

Mocarbel

et al. 2019

Sci Rep

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Vitamin D deficiency has been related with metabolic alterations in polycystic ovary syndrome (PCOS). As well, hyperactivation of adrenal axis can be programmed early in life and could be related later with PCOS development. Our aim was to establish the relationship between vitamin D and adrenal parameters with metabolic alterations and inflammation markers in PCOS. In 73 patients and 33 controls, 25-hydroxyvitamin D (25-OH-D), total and bioavailable testosterone (TT and bioT), androstenedione (A4), SHBG, cortisol, insulin, and C-reactive protein (hs-CRP) were determined; HOMA and lipid accumulation product (LAP) index were calculated. All parameters were higher in patients than in controls, except for SHBG and 25-OH-D which were lower. Binary regression analysis showed that differences in TT, bioT, A4, insulin and HOMA were independent of body mass index and waist circumference but SHBG, hs-CRP, LAP and 25-OH-D were related to body weight and fat distribution. Binary logistic regression analysis showed that cortisol and 25-OH-D could be associated to PCOS development. Correlations found between LAP and insulin, HOMA and hs-CRP confirm it is a good indicator of metabolic complications. Vitamin D and cortisol association to PCOS development justifies future research to understand the role of vitamin D in PCOS and analyze patient’s perinatal history and its possible relationship with hyperactivation of adrenal axis in adult life.

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Section: Discussionsupporting

confidence: 91%

Association Between Vitamin D and Adrenal Parameters with Metabolic and Inflammatory Markers in Polycystic Ovary Syndrome

Maidana

Fritzler

Mocarbel

et al. 2019

Sci Rep

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“…Lipid accumulation product (LAP), a simple index first described by Kahn and combining waist circumference (WC) and triglyceride concentration, is suggested as a reliable marker of cardiometabolic disorders both in the general population and in PCOS . Previous studies have already established an association of LAP index with impaired glucose tolerance, cardiovascular risk and metabolic syndrome in PCOS . Furthermore, LAP index was proposed to have the strongest diagnostic accuracy for insulin resistance when compared with body mass index (BMI), WC and waist‐to‐hip ratio (WHR), and was also suggested as sufficient to confirm an increased CVD risk in women with PCOS since it correlates with most CVD risk markers …”

Section: Introductionmentioning

confidence: 99%

“…12,13 Previous studies have already established an association of LAP index with impaired glucose tolerance, cardiovascular risk and metabolic syndrome in PCOS. [13][14][15] Furthermore, LAP index was proposed to have the strongest diagnostic accuracy for insulin resistance when compared with body mass index (BMI), WC and waist-to-hip ratio (WHR), and was also suggested as sufficient to confirm an increased CVD risk in women with PCOS since it correlates with most CVD risk markers. 16,17 Oxidative stress contributes to molecular damage to various cellular and tissue structures and contributes to morbidity in most cardiovascular diseases.…”

Section: Introductionmentioning

confidence: 99%

The association of thiol/disulphide homeostasis and lipid accumulation index with cardiovascular risk factors in overweight adolescents with polycystic ovary syndrome

Özler

Öztaş

Tokmak

et al. 2015

Clinical Endocrinology

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Objective To assess thiol/disulphide homeostasis and lipid accumulation product index, and to determine whether they are associated with increased cardiovascular disease (CVD) risk or not in overweight adolescents with polycystic ovary syndrome (PCOS). Design Case-control study. Setting Education and Research Hospital. Patients Group 1: 43 overweight+PCOS, Group 2: 45 normal weight+PCOS, Group 3: 27 overweight adolescents and Group 4: 96 age-matched, normal weight healthy controls. Interventions Serum lipid profiles, hormonal parameters and thiol/disulphide homeostasis were measured. Lipid accumulation index (LAP index) and homeostasis model assessment (HOMA-IR) were calculated. Main outcome measures The relation between thiol/disulphide homeostasis and LAP index, and increased CVD risk were evaluated in overweight adolescents with PCOS. Results Native and total thiol levels were significantly lower in overweight+PCOS adolescents when compared with both normal weight PCOS and control adolescents (P = 0Á002). LAP index values were significantly higher in Group 1 when compared separately with the rest of the three groups (P < 0Á001). Multivariable logistic regression analysis revealed serum total thiol levels of lower than 405Á45 lmol/l were independently associated with increased risk of CVD in overweight PCOS adolescents (OR: 1Á019, 95% CI: 1Á001-1Á036). In addition, a LAP index greater than 21Á54 was also associated with increased CVD risk in overweight PCOS adolescents (OR: 1Á270, 95% CI: 1Á174-1Á374). ConclusionIn conclusion, we suggest that increased LAP index and decreased total thiol levels may contribute to the increased CVD risk in overweight adolescents with PCOS.

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“…BMI assessment is commonly used for evaluation of obesity and prediction of adverse cardio-metabolic outcomes [11]. Recently some metabolic parameters of lipids were added to adiposity indices for better prognostic evaluation of cardio-metabolic adverse events [12]. However, less is known regarding the subsequent trend of obesity and other complex adiposity indexes, including lipid accumulation product (LAP), visceral adiposity index (VAI), a body shape index (ABSI) following delivery in women with a history of GDM, these women are at risk of lifelong complications, for which they need to be followed regularly to prevent any adverse events.…”

Section: Introductionmentioning

confidence: 99%

Trend of various adiposity indices in women with and without history of gestational diabetes: a population-based cohort study

et al. 2019

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Background Data of studies focusing on the trends of adiposity indices among women with prior gestational diabetes mellitus (GDM), are limited and controversial. The aim of this study was to compare overtime trends of adiposity indices in women with and without history of GDM, using data of the long term longitudinal population-based Tehran-Lipid and Glucose-Study (TLGS). Methods A total of 3395 eligible women aged (20–50 years), including 801 women with prior history of GDM and 2594 non-GDM controls were recruited from among Tehran-Lipid and Glucose-Study participants. Generalized estimating equations were applied to assess the time trend of adiposity indices including obesity, central obesity, body mass index (BMI), lipid accumulation product index (LAP), visceral adiposity index (VAI) and a body shape index (ABSI) in women with prior GDM and the non-GDM groups after further adjustment for age and BMI. Results Median follow-up years for the GDM and non-GDM groups were 12.12 and 11.62 years, respectively. Women with GDM at initiation had worse adiposity indices than their healthy counterparts. While overall odds of obesity in women with prior GDM were significantly higher those of the non-GDM groups (OR: 1.35; 95% CI, 1.03–1.7; P = 0.03), both these groups overtime revealed a positive trend in obesity (P trend < 0.001), an incremental trend which was less pronounced in GDM women (OR: 0.87; 95% CI, 0.80, 0.95; P interaction = 0.001). Women with prior GDM had higher odds of central obesity, compared to non-GDM groups (OR: 1.44; 95% CI, 1.06–1.96; P = 0.02) and showed a significant an incremental trend overtime for both groups (P trend < 0.001 for both) without statistically significant interaction in terms of their GDM status (P interaction = 0.134). Mean VAI in women with prior GDM was significantly higher than the non-GDM group (19.7, 95%CI: 6.24, 33.15, P = 0.004), although both groups overtime experienced a negative trend (− 10.9, 95%CI: -13.1, − 2.1, P < 0.001); the GDM group showed a higher decrease in VAI (mean changes: -6.62; 95% CI, − 11,-2.1; P interaction = 0.001). However overtime there was a positive trend in LAP and ABSI among both women with and without prior-GDM, though the mean changes were less obvious in women with prior GDM. Conclusion Women with prior GDM gained better control of their adiposity than non-GDM women. Nevertheless the increasing numbers of individuals with GDM and uncontrolled adiposity indices, require prompt attention be paid to the issue.

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Comparison of various adiposity indexes in women with polycystic ovary syndrome and normo-ovulatory non-hirsute women: a population-based study

Cited by 40 publications

References 54 publications

Association Between Vitamin D and Adrenal Parameters with Metabolic and Inflammatory Markers in Polycystic Ovary Syndrome

Association Between Vitamin D and Adrenal Parameters with Metabolic and Inflammatory Markers in Polycystic Ovary Syndrome

The association of thiol/disulphide homeostasis and lipid accumulation index with cardiovascular risk factors in overweight adolescents with polycystic ovary syndrome

Trend of various adiposity indices in women with and without history of gestational diabetes: a population-based cohort study

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