Comparison of Urinary Excretion of Taurine Between Elderly with Dementia and Normal Elderly

Abstract

The purpose of this study was to investigate the differences in dietary intake, serum level and urinary excretion of taurine between the elderly with dementia and the normal elderly. Subjects with dementia were 22 (8 men, 14 women) and normal were 26 (2 men, 24 women). The general characteristics, anthropometric data were considered together. The blood and urine samples were obtained from the elderly in the morning fasting state. Taurine concentrations in serum and urinary excretion were determined using high performance liquid chromatography (HPLC). Dietary intake data were collected using questionnaires, and analyzed by Computer Aided Nutritional analysis program (CAN-pro 4.0). Statistical analyses were carried out using SPSS 20.0. There were no significant differences in age and BMI (body mass index) between the elderly with dementia and the normal elderly, however, blood total cholesterol, LDL cholesterol and HDL cholesterol levels of the elderly with dementia were relatively higher than the normal elderly. The elderly men with dementia took more lipid, riboflavin higher than the normal elderly men (P < 0.05). The elderly women with dementia took more nutrients except vitamin D, vitamin B and taurine than the normal elderly (P < 0.001). There were slight differences in serum taurine level between the two groups. However, urinary excretion of taurine in the elderly with dementia was significantly higher than the normal elderly (41.2%, P < 0.05).

Urine metabolic profiling of dementia rats with vital energy deficiency using ultra‐high‐performance liquid chromatography coupled with an orbitrap mass spectrometer

“…Taurine is effective in nerve transfer, and animal experiments revealed the positive effects of taurine on improving memory [28]. This compound exists in body tissues (such as skeletal and cardiac muscles) of every human being and has especially a high concentration in the brain [29].…”

Synthesis of versatile neuromodulatory molecules by a gut microbial glutamate decarboxylase

“…Concentrations of taurine are altered in individuals with Alzheimer's disease, where reduced levels of taurine are found in the brain [15][16][17][18][19][20][21] whereas, higher urinary excretion of taurine is seen in elderly patients with dementia 22 . In a separate study, gnotobiotic mouse transplanted with fecal microbiota from an Alzheimer's patient showed lower abundance of GABA and taurine in the feces 23 .…”