What are the novel findings of this work?In fetuses with absent end-diastolic flow in the umbilical artery examined before 30 weeks' gestation, absence of end-diastolic flow for at least 30% of the cardiac cycle was associated with an increased risk of intrauterine death (sensitivity, 92% and negative predictive value (NPV), 98%) and of any (intrauterine or postnatal) death (sensitivity, 83% and NPV, 85%).
What are the clinical implications of this work?In fetuses before 30 weeks' gestation, duration of absent end-diastolic umbilical artery flow for at least 30% of the cardiac cycle length might be useful for the prediction of the risk of fetal demise. This finding is particularly relevant to growth-restricted fetuses. After evaluation in further studies, the extent of absent end-diastolic flow might facilitate the decision on timing of delivery in very preterm growth-restricted fetuses.