Comparison of Two Surgical Procedures for Use of the Acellular Dermal Matrix Graft in the Treatment of Gingival Recessions: A Randomized Controlled Clinical Study

Felipe, Maria Emília M.C.; Andrade, Patrícia Freitas de; Grisi, Márcio F. M.; Souza, Sérgio Luı́s Scombatti de; Taba, Mário; Palioto, Daniela Bazan; Novaes, Arthur B.

doi:10.1902/jop.2007.060356

Cited by 74 publications

(72 citation statements)

References 29 publications

(71 reference statements)

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“…ADM was chosen as a scaffold for gingival fibroblasts because of its three‐dimensional feature, suitable to be implanted in a host. ADM has already been shown to incorporate well into host tissues 26 in vivo and it provides favorable clinical outcomes in procedures for gingival tissue augmentation 16,17,27‐35 . Many studies were conducted to evaluate the effectiveness of ADM as a subepithelial graft compared to autogenous subepithelial connective tissue graft, with similar results between the two techniques with regard to root coverage 16,20,21,30 and gingival thickness 36 .…”

Section: Discussionmentioning

confidence: 99%

In Vitro Evaluation of Acellular Dermal Matrix as a Three‐Dimensional Scaffold for Gingival Fibroblasts Seeding

Maia

Novaes

Souza

et al. 2011

Journal of Periodontology

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Section: Discussionmentioning

confidence: 99%

In Vitro Evaluation of Acellular Dermal Matrix as a Three‐Dimensional Scaffold for Gingival Fibroblasts Seeding

Maia

Novaes

Souza

et al. 2011

Journal of Periodontology

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“…Synthetic resorbable polymers suffer from early loss of structural and mechanical properties with poor cell response [9, 10]. Natural resorbable polymers such as collagen are osteoinductive and an effective alternative to synthetic polymers due to their biocompatibility and excellent cell affinity [11–13]. However, they often suffer from rapid hydrolytic and enzymatic degradation and lack sufficient mechanical properties [14, 15].…”

Section: Introductionmentioning

confidence: 99%

Composition of elastin like polypeptide–collagen composite scaffold influences in vitro osteogenic activity of human adipose derived stem cells

2016

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Objectives Collagen-based scaffolds for guided bone regeneration (GBR) are continuously improved to overcome the mechanical weaknesses of collagen. We have previously demonstrated superior mechanical characteristics of the elastin-like polypeptide (ELP) reinforced collagen composites. The objectives of this research were to evaluate the efficacy of ELP-collagen composites to culture human adipose-derived stem cells (hASCs) and allow them to undergo osteogenic differentiation. We hypothesized that hASCs would show a superior osteogenic differentiation in stiffer ELP-collagen composites compared to the neat collagen hydrogels. Methods Composite specimens were made by varying ELP (0–18 mg/mL) and collagen (2–6 mg/mL) in a 3:1 ratio. Tensile strength, elastic modulus, and toughness were determined by uniaxial tensile testing. hASCs cultured within the composites were characterized by biochemical assays to measure cell viability, protein content, and osteogenic differentiation (alkaline phosphatase activity, osteocalcin, and Alizarin red staining). Scanning electron microscopy and energy dispersive spectroscopy was used for morphological characterization of composites. Results All composites were suitable for hASCs culture with viable cells over the 22-day culture period. The ELP-collagen composite with 18 mg/mL of ELP and 6 mg/mL of collagen had greater tensile strength and elastic modulus combined with higher osteogenic activity in terms of differentiation and subsequent mineralization over a period of 3 weeks compared to other compositions. The extra-cellular matrix deposits composed of calcium and phosphorous were specifically seen in the 18:6 mg/mL ELP-collagen composite. Significance The success of the 18:6 mg/mL ELP-collagen composite to achieve long-term, 3-dimensional culture and osteogenic differentiation of indicates its potential as a GBR scaffold.

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“…91–101 Collagen membranes derived from the extracellular matrix (ECM) of human skin and other sources have become important alternatives to their synthetic counterparts, due to their excellent cell affinity and biocompatibility. 89,102,103 Regrettably, type-I collagen has many limitations, such as low strength and fast degradation, that support the need for an improved material. 21 …”

Section: Advanced Biomaterials For Periodontal Regenerationmentioning

confidence: 99%

Advanced Scaffolds for Dental Pulp and Periodontal Regeneration

Bottino

Pankajakshan

Nör

2017

Dental Clinics of North America

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Comparison of Two Surgical Procedures for Use of the Acellular Dermal Matrix Graft in the Treatment of Gingival Recessions: A Randomized Controlled Clinical Study

Abstract: Both techniques provided significant root coverage, good esthetic results, and similar levels of postoperative discomfort. However, the control technique had statistically significantly better results for root coverage of localized gingival recessions.

Cited by 74 publications

References 29 publications

In Vitro Evaluation of Acellular Dermal Matrix as a Three‐Dimensional Scaffold for Gingival Fibroblasts Seeding

In Vitro Evaluation of Acellular Dermal Matrix as a Three‐Dimensional Scaffold for Gingival Fibroblasts Seeding

Composition of elastin like polypeptide–collagen composite scaffold influences in vitro osteogenic activity of human adipose derived stem cells

Advanced Scaffolds for Dental Pulp and Periodontal Regeneration

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