Comparison of two commercially available near-infrared spectroscopy instruments for cerebral oximetry

Abstract

Two near-infrared spectroscopy (NIRS) devices were compared with regard to their responses to changes in cerebral hemoglobin oxygenation induced by hypoxia and hypercapnia in five healthy volunteers. Sensors belonging to each NIRS device were placed on opposite sides of the volunteer's forehead. The INVOS-3100A device, approved by the United States Food and Drug Administration, records the percentage of oxyhemoglobin (HbO2) saturation and the investigational NIRO500 device records absolute changes in HbO2, deoxyhemoglobin, and total hemoglobin in micromolar concentrations referenced to an arbitrary baseline. The volunteers breathed separate mixtures of 7% CO2 in O2 and 10% O2 for 5 minutes in random order. Arterial blood pressure, end-tidal CO2 (ETCO2), arterial O2 saturation, and electrocardiographic data were continuously monitored. Hypercapnia increased (p < 0.01) ETCO2 from 42+/-2 to 56+/-3 mm Hg (mean +/- standard deviation), resulting in a 7.3+/-0.2% increase (p < 0.005) in cerebral HbO2 saturation detected by the INVOS3100A device and an 11.6+/-3 microM increase (p < 0.0008) in HbO2 detected by the NIRO500. Hypoxia decreased (p < 0.01) arterial HbO2 saturation from 98+/-1 to 87+/-3%, causing a 5.1+/-1.2% decrease (p < 0.01) in the percentage of HbO2 saturation detected by the INVOS3100A device and a 9.7+/-6.3 microM decrease in HbO2 detected by the NIRO500. The responses of the NIRO500 and the INVOS3100A instruments to changes in cerebral oxygenation resulting from hypercapnia and hypoxia were generally similar; however, responses tended to be greater when recorded by the NIRO500 device, perhaps because, unlike the INVOS3100A device, the NIRO500 does not correct for skin and bone contamination.

Multichannel wearable fNIRS‐EEG system for long‐term clinical monitoring

“…Although heterogeneity in amplitude changes were noted (amplitude differences > 10%), there was a strong correlation between for left and right Δ[HbO 2 ] and Δ[Hb] [13/16 (81%) pairs of measurements in each language task]. It must be noted that a range of acceptable concentration variations for cognitive tasks, such as language paradigms, have not yet been reported and concentration values may significantly differ from one system to another [Colier et al ; McKeating et al, ; Gomersall et al, ; Grubhofer et al, ; Cho et al, ; Yoshitani et al, ; Thavasothy et al, ; Fellahi et al, ; Luengo et al, ; Dix et al, ; Gunadi et al, ; Ehlis et al, ; Hessel et al, ]. Such variability in concentration values between systems have been attributed to device technology (e.g.…”

Comparison of cerebral tissue oxygenation values in full term and preterm newborns by the simultaneous use of two near-infrared spectroscopy devices: an absolute and a relative trending oximeter

“…8,14 In our study, lack of interference was verified before each set of data acquisition so simultaneously recorded StO 2 values were reliable (with emitters and detectors orientation similar to previous studies). 12 In a study by Moerman et al, INVOS oximeter was found to interfere with FORE-SIGHT, increasing the variability of the signal.…”

“…In some studies comparing INVOS and NIRO oximeters their performance was found to be similar (with LOA of 14.7%). 8,9 Other reports described significant disparities between cerebral StO 2 values (with mean differences of 10%) and unacceptable LOA (15.6%). 7,10,11 In a study assessing the influence of INVOS 4100 sensor location on the StO 2 measurements it was found that LOA between StO 2 at the two different sensor locations on the forehead ranged from 10.7% to 12.1% with bias of 2.3% to 2.7%, which was considered to be unacceptable disagreement.…”

“…Various statistical methods were used in different papers. [6][7][8] Comparisons were also made between different types and models of devices. In some studies comparing INVOS and NIRO oximeters their performance was found to be similar (with LOA of 14.7%).…”

The effect of bloodless pump prime on cerebral oxygenation in paediatric patients

“…Near infra-red spectroscopy reliably detects changes in cerebral oxygenation during hypocapnic (22), hypercapnic (23), hypoxic (23) or hyperoxic (22) conditions. The value of NIRS-measured haemoglobin oxygenation parameters during CPB has been proposed by several authors (11)(12)(13)(14).…”