Comparison of tropicamide and cyclopentolate for cycloplegic refractions in myopic adult refractive surgery patients

Hofmeister, Elizabeth M.; Kaupp, Sandor E.; Schallhorn, Steven C.

doi:10.1016/j.jcrs.2004.10.068

Cited by 47 publications

(42 citation statements)

References 10 publications

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“…Thus, the significance of this study is difficult to determine due to the disagreement in the mean values of the ACA, and due to the fact that it did not use a control group (30) . In addition, the cycloplegic effects of one application of 1% tropicamide are less than for two applications of 1% cyclopentolate (31) , as used in our study. Therefore, to our knowledge, this study is the first to use the Pentacam system to examine the anterior segment changes that arise in young adults following an efficient cycloplegic application.…”

Section: Discussionmentioning

confidence: 44%

Effects of 1% cyclopentolate hydrochloride on anterior segment parameters obtained with Pentacam in young adults

Arıcı¹,

Türk²,

Ceylan³

et al. 2014

Arquivos Brasileiros De Oftalmologia

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Purpose: To investigate the effects of topically applied 1% cyclopentolate hydrochloride on anterior segment parameters obtained with a Pentacam rotating Scheimpflug camera in healthy young adults. Methods: Anterior segment analyses of 25 eyes from 25 young adults (Group 1), before and after 45 min of 1% cyclopentolate hydrochloride application, were performed. For a control group (cycloplegia-free, Group 2), 24 eyes of 24 age-and sex-matched healthy cases were evaluated twice at 45 min intervals. The results obtained from the groups were compared statistically. Results: The mean ages of the groups were 23.04 ± 3.42 (range, 18-29) and 22.4 ± 2.05 (range, 18-27) years for Groups 1 and 2, respectively (p=0.259). In Group 1, measurements between the two analyses were significantly different for the values of anterior chamber depth (ACD), anterior chamber angle (ACA), and anterior chamber volume (ACV) (p<0.05), whereas no statistical difference was found for the central corneal thickness (CCT) and keratometry (K1, K2) measurements. In Group 2, none of these parameters were statistically different between the two analyses. Conclusions: Topically applied 1% cyclopentolate hydrochloride caused an increase in the ACD and ACV values, and a decrease in the ACA value. However, it had no significant effect on the CCT and keratometry measurements. It is important to consider these effects when using the Pentacam device on young adults with cycloplegia and when applying it for various reasons.

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Section: Discussionmentioning

confidence: 44%

Effects of 1% cyclopentolate hydrochloride on anterior segment parameters obtained with Pentacam in young adults

Arıcı¹,

Türk²,

Ceylan³

et al. 2014

Arquivos Brasileiros De Oftalmologia

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“…All participants were dilated in order to reveal the full extent of their lower-and higherorder aberrations and to minimise any accommodative effects that may alter their refraction. Both eyes of each individual were dilated using tropicamide 1% (mydriatic), which has been shown to be an effective topical mydriatic for dilated ocular exams [21] and also has a significant cycloplegic effect for objective refraction assessment [22][23][24] . All wavefront aberration maps were calculated for the central 6.0-mm pupillary zone.…”

Section: Study Protocolmentioning

confidence: 99%

Role of Genetic Factors in Lower- and Higher-Order Aberrations – The Genes in Myopia Twin Study

Dirani

Chamberlain²,

Couper³

et al. 2009

Ophthalmic Res

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Aims: We intended to investigate the relative genetic contribution in wavefront aberrations using a sub-group of twins recruited in the Genes in Myopia twin study, and subsequently provide direction for future studies into the aetiology of mono-chromatic aberrations. To our knowledge, the Genes in Myopia twin study is the first study to explore the role of genetic factors in both lower- and higher-order aberrations in a Caucasian population. Methods: Each individual completed a general questionnaire and underwent a comprehensive eye examination. Higher-order wavefront aberrations were calculated with Zernike coefficients up to the fourth order. Results: A total of 46 twin pairs with a mean age of 65.3 years were included in the analysis. Monozygotic intra-pair correlations were significantly higher compared to those in dizygotic twin pairs for defocus aberrations (p < 0.05). A trend for a genetic component was identified for higher-order aberrations. Conclusion: Genetic studies into refraction typically explore the genetic effects of lower-order aberrations such as myopia and hypermetropia; however, there is little to no research into the genetic basis of higher-order aberrations. The Genes in Myopia twin study indicates a potential genetic role for higher-order aberrations and provides useful insights into the aetiology of refractive error.

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“…Cyclopentolate provides cycloplegia for 12 to 24 hours, while tropicamide is expected to provide cycloplegia for 4 to 10 hours. Findings from a previous survey reveal that some patients prefer tropicamide due to a more rapid return of near vision and a lesser stinging sensation relative to cyclopentolate [6]. Tropicamide requires a shorter duration to obtain maximum cycloplegia, and rarely induces systemic side effects [789].…”

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confidence: 99%

Cycloplegic Refraction in Hyperopic Children: Effectiveness of a 0.5% Tropicamide and 0.5% Phenylephrine Addition to 1% Cyclopentolate Regimen

Yoo

Cho

Kim

et al. 2017

Korean J Ophthalmol

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PurposeTo evaluate the effectiveness of a cycloplegic regimen using 0.5% tropicamide and 0.5% phenylephrine (Tropherine, Hanmi Pharm), in addition to 1% cyclopentolate, in hyperopic children.MethodsThe medical records of hyperopic patients below the age of 14 years who had undergone cycloplegic retinoscopy were retrospectively reviewed. Cycloplegic refractions were performed using one of two cycloplegic regimens. Regimen 1 was a Tropherine-added regimen comprising the administration of one drop of 1% cyclopentolate followed by two to three drops of Tropherine added at 15-minute intervals. Regimen 2 was a cyclopentolate-only regimen comprising the administration of three to four drops of 1% cyclopentolate at 15-minute intervals. The mean difference between noncycloplegic and cycloplegic refraction was compared between the two regimens.ResultsA total of 308 eyes of 308 hyperopic children were included. The mean difference (±standard deviation) in the spherical equivalent (SE) between cycloplegic and noncycloplegic refraction was significantly larger in regimen 2 than in regimen 1, with values of +1.70 ± 1.03 diopters (D) and +1.25 ± 0.89 D, respectively (p=0.001). The SE change after cycloplegia was significantly different between the two regimens only in patients aged 5 years or younger (p=0.001), particularly in those with high hyperopia with an SE ≥5 D (p=0.005) or fully accommodative esotropia (p=0.009). There was no significant difference between the two regimens in patients older than 5 years, regardless of the presence of high hyperopia or fully accommodative esotropia.ConclusionsThe Tropherine-added regimen exerted a weaker cycloplegic effect than the cyclopentolate-only regimen, particularly in children under the age of 5 years with high hyperopia or fully accommodative esotropia. However, the difference in refraction between the two regimens was small. A Tropherine-added regimen can be effective in hyperopic children, with less associated discomfort than the instillation of cyclopentolate.

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Comparison of tropicamide and cyclopentolate for cycloplegic refractions in myopic adult refractive surgery patients

Abstract: There was no statistically significant difference in mean cycloplegic refractions. Cyclopentolate was more effective than tropicamide in reducing accommodative amplitude in adult myopes (near-point testing). Patients strongly preferred tropicamide.

Cited by 47 publications

References 10 publications

Effects of 1% cyclopentolate hydrochloride on anterior segment parameters obtained with Pentacam in young adults

Effects of 1% cyclopentolate hydrochloride on anterior segment parameters obtained with Pentacam in young adults

Role of Genetic Factors in Lower- and Higher-Order Aberrations – The Genes in Myopia Twin Study

Cycloplegic Refraction in Hyperopic Children: Effectiveness of a 0.5% Tropicamide and 0.5% Phenylephrine Addition to 1% Cyclopentolate Regimen

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