Comparison of Treatment Results Between Adult and Juvenile Nasopharyngeal Carcinoma

Downing, N. Lance; Wolden, Suzanne L.; Wong, Priscilla H.; Petrik, David; Hara, Wendy; Le, Quynh‐Thu

doi:10.1016/j.ijrobp.2008.12.030

Cited by 34 publications

(25 citation statements)

References 27 publications

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“…Nasopharyngeal carcinomas represent approximately 1 % of all childhood cancers and 40-50 % of all malignancies involving the nasopharynx in children [2]. Studies have suggested that juvenile NPC is similar to adult NPC in etiology by its frequent concomitant infection with the Epstein-Barr virus, its relation to the consumption of salted fish containing volatile nitrosamines, and its male predominance [3]. The World Health Organization (WHO) has classified NPC into three subtypes: Type I is keratinising squamous-cell carcinoma; Type II is a non-keratinising epidermoid carcinoma; and Type III is undifferentiated carcinoma [4].…”

Section: Introductionmentioning

confidence: 99%

Prognostic aspects in the treatment of juvenile nasopharyngeal carcinoma: a systematic review

Gioacchini

Tulli

Kaleci

et al. 2016

Eur Arch Otorhinolaryngol

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To systematically review and discuss the published data about treatments and outcomes for children and adolescents affected by nasopharyngeal carcinoma. In April 2015, an appropriate string was run on PubMed to retrieve all relevant articles. A cross-check was performed by two of the authors on abstracts and full-text articles found using the selected inclusion and exclusion criteria. A meta-analysis concerning the rate of reported disease-free survival and overall survival was performed. Fifteen studies were identified comprising a total of 865 subjects affected by nasopharyngeal carcinoma. According to the American Joint Committee for Cancer Staging system, the majority of tumors were classified as Stage IV (57.3 %). All included patients underwent radiotherapy, while 687 (79.4 %) received also some regimen of chemotherapy. On the basis of our statistical analysis, the mean (95 % CI) rate of disease-free survival was 66 % (95 % CI 56-76). The mean (95 % CI) rate of the overall survival resulted 68 % (95 % CI 58-78). On the basis of our analysis, it may be affirmed that the prognosis of juvenile nasopharyngeal carcinoma is still unsatisfactory. New reports on homogeneous populations are needed to better define the most influencing prognostic factors and to evaluate the introduction of possible alternative therapeutic protocols.

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Section: Introductionmentioning

confidence: 99%

Prognostic aspects in the treatment of juvenile nasopharyngeal carcinoma: a systematic review

Gioacchini

Tulli

Kaleci

et al. 2016

Eur Arch Otorhinolaryngol

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“…The main indicator for poor prognosis was distant metastases which were present in only 12% of cases as compared to 2.7% to 27% in previous series. It is noteworthy that, compared with adults [18], adolescents NPC have more advanced stages (92% vs. 67% Stage III-IV) but significantly better overall survival (71% vs. 58% 5y-OS).…”

Section: Discussionmentioning

confidence: 94%

“…Only 2/7 patients with FL-HCC and 1/5 HCC were alive with a follow-up of 47, 77 and 74 months but after multiple recurrences treated with various combined therapies (multiple surgeries, chemotherapy, hyperthermic intraperitoneal chemotherapy, inhibitor tyrosine kinase, radiofrequency). The median survival of patients was 26 months (12-78) for FL-HCC and 16.5 months (8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25) for HCC.…”

Section: Liver Carcinomamentioning

confidence: 99%

Overview of Carcinomas in Adolescents: A Descriptive Study Over Twenty Years

Fresneau¹,

Fabrè²,

Janot³

et al. 2015

Arch Surg Oncol

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“…Similarly in our study, majority of patients presented with stage III and IV 68.2 %. Amaro et al [39] showed 54 % patient in Stage IV, Downing et al [40] showed 92 % presented in stage III, Tiong et al [41] showed 85 % of the patient presented in advanced stage (stage III and IV), Skinner et al [42] showed 70 % of patients presented in Stage III disease and Ibrahim et al [43] also showed the advanced stage 86 % presentation of the patients in stage III and IV.…”

Section: Discussionmentioning

confidence: 99%

Nasopharyngeal Carcinoma: A 15 Year Study with Respect to Clinicodemography and Survival Analysis

Wani

Khan

Wani³

et al. 2016

Indian J Otolaryngol Head Neck Surg

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Nasopharyngeal carcinoma (NPC) is a rare malignancy in Kashmir with distinct pattern, hence we planned to study its clinicodemographic and survival profile. Kashmir has unique lifestyle and dietary habits which may be the source of carcinogenic compounds, most likely implicated in causation of NPC. A total of 148 patients of NPC registered from January 2000 to December 2014 were analyzed. The Mean ± SD age was 45.15 ± 17.092 years (range 11-85 years). The males were 72.3 % (N = 107) with male: female ratio of 2.61:1. Most of the patients were from rural area 81.90 % (N = 95) and non-smokers were 53.44 % (N = 62). Neck swelling was commonest presentation. WHO Type III NPC was commonest histopathological diagnosis 65.3 % (N = 92). Stage IV 36.1 % (N = 51) was commonest stage followed by stage III was 32 % (N = 46). Majority of the patients of NPC received CCRT 68.7 % (N = 78) followed by SCRT 13 % (N = 15) and Induction ? CCRT 13 % (N = 15). The overall mean survival of NPC was 49.56 months. There was no significant correlation of age, gender, smoking, histopathology and treatment on the overall survival. However the stage was the only strong predictor of overall survival. Also the patients with intracranial extension had low survival which is turn depicts the advanced stage of disease. NPC survival is directly related to the stage of the disease irrespective of the treatment modality received. The negative EBV status in our patients implies that there are other risk factors involved in the causation of NPC for which further studies are needed to establish the etiological insult.

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Comparison of Treatment Results Between Adult and Juvenile Nasopharyngeal Carcinoma

Cited by 34 publications

References 27 publications

Prognostic aspects in the treatment of juvenile nasopharyngeal carcinoma: a systematic review

Prognostic aspects in the treatment of juvenile nasopharyngeal carcinoma: a systematic review

Overview of Carcinomas in Adolescents: A Descriptive Study Over Twenty Years

Nasopharyngeal Carcinoma: A 15 Year Study with Respect to Clinicodemography and Survival Analysis

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