Comparison of Treatment Outcome between Repetitive Transcranial Magnetic Stimulation (rTMS) and Transcutaneous Direct Current Stimulation (tDCS) in Intractable Tinnitus

Bae, Seong Hoon; Moon, Seo Jin; Lee, Jeong Gum; Yim, Yun Kyung; Oh, Hee So; Han, Dong; Moon, In-Sung

doi:10.3390/jcm10040635

Cited by 3 publications

(3 citation statements)

References 27 publications

(38 reference statements)

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“…Similar to hearing aids, the short duration of this study may not adequately reflect the long-term effect of the treatment. A previous study reported that patients who received rTMS or tDCS demonstrated a continuous reduction in tinnitus loudness and awareness (24). Furthermore, not all patients respond to neuromodulation, and rTMS has been shown to be more effective in women, individually adopted parameters, and comorbid anxiety or depression (25).…”

Section: Discussionmentioning

confidence: 99%

Initial Response to Combination Therapies for Tinnitus: Lessons Learned From a Retrospective Analysis

Shin,

Byun,

Lee

2023

Otol Neurotol

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Objective To investigate the initial reduction of tinnitus effects by combining common therapies applicable in general otology clinics and establishing optimal treatment strategies. Study Design Retrospective cohort study. Setting A tertiary university hospital. Patients Patients with nonpulsatile subjective tinnitus who visited the hospital between January and December 2022. Intervention(s) Combination therapies consisting of at least one of the directive counseling based on the neurophysiological model, hearing aids, medication, and/or neuromodulation were performed. Main Outcome Measure(s) Tinnitus Handicap Inventory (THI) questionnaire at both their initial visit and 1-month follow-up. Results A total of 151 patients were enrolled. THI improvement of 20 points or more was observed in 31.8% of participants. One-way analysis of variance revealed that counseling had a significant reduction in THI, whereas neuromodulation, medication, and hearing aids did not. THI improvement was significantly associated with received counseling, severity of initial THI, and mean loudness discomfort level. Hearing aids and neuromodulation were not significant prognostic factors for improvement. Conclusion Counseling alone is the best treatment for most patients with tinnitus. There will be other patients with tinnitus that, in addition to counseling, would benefit from hearing aids, medications, and/or certain forms of neuromodulation.

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Section: Discussionmentioning

confidence: 99%

Initial Response to Combination Therapies for Tinnitus: Lessons Learned From a Retrospective Analysis

Shin,

Byun,

Lee

2023

Otol Neurotol

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“…A total of 18 studies involving DLPFC were found. 48 , 56 – 72 Vanneste et al 60 showed that single bilateral DLPFC stimulation significantly inhibited tinnitus loudness and annoyance. Faber et al 58 reported that multiple sessions of tDCS of DLPFC only yielded benefits in improving tinnitus distress, while Shekhawat and Vanneste 66 found that DLPFC was effective for improving tinnitus loudness.…”

Section: Dorsolateral Prefrontal Cortexmentioning

confidence: 99%

State of the art: non-invasive electrical stimulation for the treatment of chronic tinnitus

Chen

Wang

et al. 2023

Therapeutic Advances in Chronic Disease

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Subjective tinnitus is the perception of sound in the absence of external stimulation. Neuromodulation is a novel method with promising properties for application in tinnitus management. This study sought to review the types of non-invasive electrical stimulation in tinnitus to provide the foothold for further research. PubMed, EMBASE, and Cochrane databases were searched for studies on the modulation of tinnitus by non-invasive electrical stimulation. Among the four forms of non-invasive electrical modulation, transcranial direct current stimulation, transcranial random noise stimulation, and transauricular vagus nerve stimulation yielded promising results, whereas the effect of transcranial alternating current stimulation in the treatment of tinnitus has not been confirmed. Non-invasive electrical stimulation can effectively suppress tinnitus perception in some patients. However, the heterogeneity in parameter settings leads to scattered and poorly replicated findings. Further high-quality studies are needed to identify optimal parameters to develop more acceptable protocols for tinnitus modulation.

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“…One study compared the treatment outcomes between rTMS and tDCS and revealed comparable results in reducing tinnitus in terms of the changes in Tinnitus Handicap Inventory (THI) scores, Numeric Rating Scale (NRS) scores, and duration [21]. Further studies suggest that combining neuromodulation techniques (rTMS + tDCS) improves the treatment outcomes.…”

Section: Introductionmentioning

confidence: 99%

Personalized Neuromodulation: A Novel Strategy for Improving Tinnitus Treatment

Jeon,

Choi,

Kang

et al. 2023

JCM

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This study evaluated the efficacy of personalized neuromodulation, where treatment modalities are chosen based on the patient’s responses in a pilot trial. A total of 71 patients with tinnitus were divided into two groups: a personalized group and a randomized neuromodulation group. In the personalized group (n = 35), repetitive transcranial magnetic stimulation (rTMS) and transcranial direct-current stimulation (tDCS) were assessed in a pilot trial, and responsive modalities were administered to 16 patients, while the non-responders (n = 19) were randomly assigned to rTMS, tDCS, or combined modalities. Patients in the randomized group (n = 36) were randomly allocated to rTMS, tDCS, or combined modalities. The Tinnitus Handicap Inventory (THI) score improvement after 10 sessions of each neuromodulation was significantly greater in the personalized group than in the randomized group (p = 0.043), with no significant differences in tinnitus loudness, distress, or awareness. The treatment success rate was highest in the personalized responder subgroup (92.3%), and significantly greater than that in the non-responder subgroup (53.0%; p = 0.042) and the randomized group (56.7%; p = 0.033). Personalized neuromodulation, where the treatment modality is chosen based on the patient’s responses in a pilot trial, is an advantageous strategy for treating tinnitus.

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Comparison of Treatment Outcome between Repetitive Transcranial Magnetic Stimulation (rTMS) and Transcutaneous Direct Current Stimulation (tDCS) in Intractable Tinnitus

Cited by 3 publications

References 27 publications

Initial Response to Combination Therapies for Tinnitus: Lessons Learned From a Retrospective Analysis

Initial Response to Combination Therapies for Tinnitus: Lessons Learned From a Retrospective Analysis

State of the art: non-invasive electrical stimulation for the treatment of chronic tinnitus

Personalized Neuromodulation: A Novel Strategy for Improving Tinnitus Treatment

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