Comparison of Time Domain and Spectral Domain Optical Coherence Tomography in Measurement of Macular Thickness in Macular Edema Secondary to Diabetic Retinopathy and Retinal Vein Occlusion

Abstract

Purpose. To evaluate macular thickness, agreement, and intraclass repeatability in three optical coherence tomography (OCT) devices: the time domain (TD) Stratus OCT and two spectral domain (SD) OCTs, Spectralis and Cirrus SD-OCT, in eyes with macular edema secondary to diabetic retinopathy (DR) and retinal vein occlusion (VO). Methods. In a prospective observational study at a university-based retina practice, retinal thickness tomography was performed simultaneously for fifty-eight patients (91 eyes) with DR and VO employing a time domain and two spectral domain OCTs. Agreement in macular measurements was assessed by constructing Bland-Altman plots. Intraclass repeatability was assessed by intraclass correlation coefficients (ICCs). Results. Based on the Bland-Altman plots for central macular thickness, there was low agreement between the measurements of Cirrus SD-OCT and Stratus OCT, Spectralis OCT and Stratus OCT, as well as Spectralis OCT and Cirrus SD-OCT among DR and RVO patients. All three devices demonstrated high intraclass repeatability, with ICC of 98% for Stratus OCT, 97% for Cirrus SD-OCT, and 100% for Spectralis OCT among DR patients. The ICC was 97% for Stratus OCT, 79% for Cirrus SD-OCT, and 91% for Spectralis OCT among RVO patients. Conclusion. There are low agreements among interdevice measurements. However, intraclass repeatability is high in both TD and SD-OCT devices.

Intravitreal Triamcinolone Acetonide Compared With Bevacizumab for the Treatment of Patients With Macular Edema Secondary to Central Retinal Vein Occlusion

“…Spectral-domain OCT machines provide better images but take longer to obtain data. A recent study by Hatef et al 26 showed that both time-domain and spectral-domain OCT devices demonstrated high intraclass repeatability. The main advantage of spectral-domain over time-domain OCT was its ability to obtain more detailed images and detect small changes in the normal anatomy of the retina.…”

Diurnal Variation of Retinal Thickness in Healthy Subjects

“…It is equipped with a superluminescent diode laser with a wavelength of 870 nm and is capable of obtaining up to 40,000 A-scans/s with an axial optical resolution (in tissue) of approximately 7 Km (the pixel resolution of the OCT images is 3.9 Km). 8 The instrument features two scanning modes: the highresolution (HR) mode with a transverse isotropic resolution of 5 Km and the high-speed (HS) mode with a transverse isotropic resolution of 11 Km. A full peripapillary RNFL circular scan contains 1536 versus 768 A-scans in the HR versus HS modes, respectively.…”

“…8 Based on the ETDRS (Early Treatment Diabetic Retinopathy Study) model, the instrument provides a retinal thickness/volume map with three concentric circular areas with respective diameters of 1, 3, and 6 mm centered on the fixation point. The 3-and 6-mm zones were each divided into four subfields: superior, inferior, nasal, and temporal.…”

Comparison of thickness values in nine macular subfields using time-domain and spectral-domain optical coherence tomography

“…Az egyes műszerek mérései között gyenge korrelációt találtak, de a mérések reprodukálhatósága minden műszernél magas volt (intraclass korrelációs koefficiens diabeteses maculaoedemában: Stratus OCT: 98%, Cirrus HD-OCT: 97%, Heidelberg Spectralis OCT: 100%, vénás okklúzióban: Stratus OCT: 97%, Cirrus HD-OCT: 79%, Heidelberg Spectralis OCT: 91%) [18].…”