Comparison of tiletamine‐zolazepam‐ketamine and tiletamine‐zolazepam‐ketamine‐xylazine anaesthesia in sheep

Abstract

The anaesthetic effects of intravenous tiletamine-zolazepam 6.6 mg/kg-ketamine 6.6 mg/kg (TK) and tiletamine-zolazepam 6.6 mg/kg-ketamine 6.6 mg/kg-xylazine 0.11 mg/kg (TKX) were evaluated in six wethers. Heart rate, respiration rate, arterial blood pressure, and the electrocardiogram were monitored during anaesthesia. Analgesia was tested by electrical stimulation in the left flank. Atropine (0.03 mg/kg) was given intramuscularly before induction, but after recording of baseline heart rate and respiratory rate. The duration of analgesia was 28.7 +/- 6.9 min with TK and 82.8 +/- 26.6 min with TKX. Heart rate increased significantly within 5 min after TK or TKX administration. Respiratory rate remained unchanged after TK administration, but increased significantly from 5 to 45 min after TKX administration. Arterial blood pressure decreased significantly at 15 min with TK and 30 min with TKX. Sheep remained recumbent for 201 min with TK and 166 min with TKX. All recovered uneventfully. We conclude that either TK or TKX may be used for anaesthetising sheep.

Comparative Effect of Propofol and Thiopentone Sodium in Sheep Sedated with Xylazine Hydrochloride

“…After induction of anesthesia with propofol, pulse rate significantly increased (P< 0.01) and respiratory rate siginificantly decreased (P< 0.01). Similar results were reported by other workers in sheep (Runciman et al, 1990;Lin et al, 1994), in goats (Celestine et al, 2014;Prassinos et al, 2005) and in calves (Sebel et al, 2006). Decrease in the pulse rate after initial transient increase has been reported in goat (Celestine et al, 2014).…”

“…Decrease in the pulse rate after initial transient increase has been reported in goat (Celestine et al, 2014). Decrease in respiratory rate after propofol anesthesia has also been reported by other researchers in sheep (Lin et al, 1994), and in goats (Celestine et al, 2014;Prassinos et al, 2005). This study shows that thiopentone has more respiratory depressant effect (20.00 + 0.45) as compared to propofol anesthesia (22.17 + 0.60).…”

Anesthetic and physiologic effects of tiletamine, zolazepam, ketamine, and xylazine combination (TKX) in feral cats undergoing surgical sterilization

“…The combination of tiletamine, zolazepam, ketamine, and xylazine (TKX) has been used in several species for surgical anesthesia (Ko et al, 1993a,b; Lin et al, 1994; Williams et al, 2002). The pharmacological profiles of the drugs that comprise TKX have been reviewed elsewhere (Williams et al, 2002).…”

Koyunlarda Detomidin-Butarfanol-Ketamin ve Atipamezol’ün Klinik, Kardiyorespiratorik, Hematolojik Parametreler Üzerine Etkileri

“…The increase of PCO 2 attribute to decreasing in PH and BE (ecf) values. The decrease in BE (ecf) value indicates the accompanying of a mild metabolic acidosis (16). At the same time HCO 3 , BE(ecf) and CtCO 2 values increased.…”

“…D induced hypoxemia and the resultant tachypnea in sheep has been well documented (8). It is believed that this is due to alpha-2 adrenoreceptor mediated contraction of the airway or a reduction in pulmonary blood flow (16,20). However, absence of any change in RR after D, B and K administration at 10 min of anaesthesia suggests that D and B induced hypoxemia and subsequent tachyp- (6).…”